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Title:
MEFUPARIB HYDROCHLORIDE POLYMORPHIC SUBSTANCE AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2020/119772
Kind Code:
A1
Abstract:
Provided is a mefuparib hydrochloride polymorphic substance and a preparation method therefor and an application thereof. Specifically, provided is four crystal forms, i.e., D, E, F, and G, of 2-[4-(methylaminomethyl)phenyl]-5-fluorine-benzofuran-7-formamide hydrochloride (formula I) and a preparation method therefor and use in drug preparation.

Inventors:
SHEN XIAOKUN (CN)
YANG CHUNHAO (CN)
Application Number:
PCT/CN2019/124968
Publication Date:
June 18, 2020
Filing Date:
December 13, 2019
Export Citation:
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Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
CONVALIFE SHANGHAI CO LTD (CN)
International Classes:
C07D307/81; A61K31/343; A61P3/10; A61P9/00; A61P19/02; A61P29/00; A61P35/00
Domestic Patent References:
WO2018228205A12018-12-20
Foreign References:
CN103242273A2013-08-14
CN102627620A2012-08-08
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
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