MELANIN FORMATION INHIBITOR AND PREPARATION FOR EXTERNAL APPLICATION

WIPO Patent Application WO/2010/071051

A1

Disclosed is a melanin formation inhibitor which is safe and has a high activity. More specifically, the melanin formation inhibitor contains a compound having a germacrone-like skeleton represented by chemical formula (1) as an active ingredient.  The compound can be produced by the purification from a plant such as a zedoary plant (Curcuma zedoaria Roscoe (Zingiberaceae)) or a turmeric plant (Curcuma longa [syn. C. domestica]), and has a melanin formation inhibitory activity 400 times higher than that of arbutin.  The melanin formation inhibitor can be added, together with an additive such as a surfactant, a pH-adjusting agent, a water-soluble polymer, an antioxidant agent and a moisturizing agent, to a base material for a cosmetic or a pharmaceutical external preparation (wherein the base material comprises various types of oily raw materials, water, an alcohol, a polyhydric alcohol or the like) in such an amount that the content of the melanin formation inhibitor in the cosmetic or preparation becomes 0.000001 to 1.0%.

SUETSUGU KAZUHIRO (JP)
MORITA SATOSHI (JP)
YAMADA YASUHIRO (JP)

PCT/JP2009/070535

June 24, 2010

December 08, 2009

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NARIS COSMETICS CO LTD (JP)
SUETSUGU KAZUHIRO (JP)
MORITA SATOSHI (JP)
YAMADA YASUHIRO (JP)

A61K8/49; A61K31/341; A61P17/00; A61P43/00; A61Q19/02; C07D493/04

JP2004256485A	2004-09-16
JP2007269705A	2007-10-18
JP2007230882A	2007-09-13

H.MAKABE ET AL.: "Anti-inflammatory sesquiterpenes from Curcuma zedoaria", NATURAL PRODUCT RESEARCH, vol. 20, no. 7, June 2006 (2006-06-01), pages 680 - 685

TANAKA, Mitsuo et al. (JP)
Mitsuo Tanaka (JP)

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