Title:
MELANOCORTIN-4 RECEPTOR AGONIST
Document Type and Number:
WIPO Patent Application WO/2022/182194
Kind Code:
A1
Abstract:
The present invention relates to a compound showing an excellent agonistic activity for a melanocortin receptor and, more specifically, to the compound of chemical formula 1, a pharmaceutical composition containing same as an active ingredient, and a use thereof. In detail, the compound of the present invention exhibits an excellent agonistic activity for melanocortin-4 receptor and thus, can be advantageously used especially for preventing or treating obesity, diabetes, inflammation, and impotence.
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Inventors:
CHOI EUN SIL (KR)
PARK HEE DONG (KR)
KANG SEUNG WAN (KR)
AHN HYE WON (KR)
PARK DEOK SEONG (KR)
PARK HEE DONG (KR)
KANG SEUNG WAN (KR)
AHN HYE WON (KR)
PARK DEOK SEONG (KR)
Application Number:
PCT/KR2022/002782
Publication Date:
September 01, 2022
Filing Date:
February 25, 2022
Export Citation:
Assignee:
LG CHEMICAL LTD (KR)
International Classes:
C07D403/06; A61K31/4025; A61K31/5377; A61P3/04; A61P3/10; A61P15/10; A61P29/00
Domestic Patent References:
| WO2000074679A1 | 2000-12-14 | |||
| WO2008007930A1 | 2008-01-17 | |||
| WO2021091283A1 | 2021-05-14 | |||
| WO2008007930A1 | 2008-01-17 | |||
| WO2010056022A2 | 2010-05-20 | |||
| WO2004092126A2 | 2004-10-28 |
Foreign References:
| KR20100053458A | 2010-05-20 | |||
| US20070129346A1 | 2007-06-07 | |||
| US20040058936A1 | 2004-03-25 |
Other References:
SCHWARTZ ET AL., NATURE, vol. 404, 2000, pages 661 - 671
WIKBERG ET AL., PHARM RES, vol. 42, no. 5, 2000, pages 393 - 420
WIKBERG, EUR. J. PHARMACOL, vol. 375, 1999, pages 295 - 310
DOUGLAS ET AL., EUR J PHARM, vol. 450, 2002, pages 93 - 109
O'RAHILLY ET AL., NATURE MED, vol. 10, 2004, pages 351 - 352
YEN, TT ET AL., FASEB J, vol. 8, 1994, pages 479 - 488
LU D. ET AL., NATURE, vol. 371, 1994, pages 799 - 802
SHUTTER ET AL., ENES DEV., vol. 11, 1997, pages 593 - 602
OLLMAN ET AL., SCIENCE, vol. 278, 1997, pages 135 - 138
KASK ET AL., BIOCHEM. BIOPHYS. RES. COMM., vol. 245, 1998, pages 90 - 93
THIELE T. E. ET AL., AM J PHYSIOL, vol. 274, 1998, pages R248 - 54
LEE M. D. ET AL., FASEB J, vol. 12, 1998, pages A552
MURPHY B. ET AL., J APPL PHYSIOL, vol. 89, 2000, pages 273 - 82
MARSH ET AL., NAT GENET, vol. 21, 1999, pages 119 - 122
WIKBERG ET AL., PHARM RES, vol. 42, no. 5, 2000, pages 393 - 420
WIKBERG, EUR. J. PHARMACOL, vol. 375, 1999, pages 295 - 310
DOUGLAS ET AL., EUR J PHARM, vol. 450, 2002, pages 93 - 109
O'RAHILLY ET AL., NATURE MED, vol. 10, 2004, pages 351 - 352
YEN, TT ET AL., FASEB J, vol. 8, 1994, pages 479 - 488
LU D. ET AL., NATURE, vol. 371, 1994, pages 799 - 802
SHUTTER ET AL., ENES DEV., vol. 11, 1997, pages 593 - 602
OLLMAN ET AL., SCIENCE, vol. 278, 1997, pages 135 - 138
KASK ET AL., BIOCHEM. BIOPHYS. RES. COMM., vol. 245, 1998, pages 90 - 93
THIELE T. E. ET AL., AM J PHYSIOL, vol. 274, 1998, pages R248 - 54
LEE M. D. ET AL., FASEB J, vol. 12, 1998, pages A552
MURPHY B. ET AL., J APPL PHYSIOL, vol. 89, 2000, pages 273 - 82
MARSH ET AL., NAT GENET, vol. 21, 1999, pages 119 - 122
Attorney, Agent or Firm:
HANSUNG INTELLECTUAL PROPERTY (KR)
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