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Title:
MELANOMA-SPECIFIC BIOMARKER AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/152352
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing: a marker molecule which enables the highly efficient diagnosis of melanoma; and a novel therapy target molecule which can be utilized in an effective therapy method. As melanoma-specific markers, PDZRN3, DTX3L, CSS3 and BRP44L are provided. Also provided are a test method, a therapy method and others each using these biological molecules.

Inventors:
KATO MASASHI (JP)
YAJIMA ICHIRO (JP)
TAKEDA KOZUE (JP)
GOTO YUJI (JP)
Application Number:
JP2016/054968
Publication Date:
September 29, 2016
Filing Date:
February 20, 2016
Export Citation:
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Assignee:
NAT UNIV CORP NAGOYA UNIV (JP)
CHUBU UNIV EDUCATIONAL FOUND (JP)
International Classes:
C12Q1/68; A61K31/7105; A61K31/713; A61K38/00; A61K45/00; A61K48/00; A61P17/00; A61P43/00; C07K14/47; C12N15/09; G01N33/50; G01N33/574
Domestic Patent References:
WO2013192616A12013-12-27
WO2013148845A12013-10-03
Foreign References:
JP2011520451A2011-07-21
JP2010537629A2010-12-09
Other References:
DANTE L. ET AL.: "Cloning and developmental expression of zebrafish pdzrn3.", INT J DEV BIOL., vol. 55, no. 10-12, 2011, pages 989 - 993, XP055317704
YAJIMA I. ET AL.: "Reduced GNG2 expression levels in mouse malignant melanomas and human melanoma cell lines.", AM J CANCER RES., vol. 2, no. 3, 2012, pages 322 - 329, XP055317709
YADA T. ET AL.: "Chondroitin sulfate synthase-3. Molecular cloning and characterization.", J BIOL CHEM., vol. 278, no. 41, 2003, pages 39711 - 39725, XP002976568
DATABASE EMBL 24 May 2008 (2008-05-24), ISOGAI T ET AL.: "Homo sapiens brain protein 44-like (BRP44L), mRNA.", XP055317729, Database accession no. AK312201
THANG ND. ET AL.: "Deltex-3-like (DTX3L) stimulates metastasis of melanoma through FAK/PI3K/AKT but not MEK/ERK pathway.", ONCOTARGET, vol. 6, no. 16, 10 June 2015 (2015-06-10), pages 14290 - 14299, XP055317738
YAJIMA I ET AL.: "Functional analysis of GNG2 in human malignant melanoma cells.", J DERMATOL SCI., vol. 68, no. 3, 2012, pages 172 - 178, XP055317739
Attorney, Agent or Firm:
HAGINO Mikiharu (JP)
Kanji Hagino (JP)
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