Title:
MELT EMULSIFICATION
Document Type and Number:
WIPO Patent Application WO/2011/116154
Kind Code:
A3
Abstract:
The present invention generally relates to colloidal systems, which may include colloidal particles and/or other types of particles. One aspect of the invention is generally directed to a system comprising fluidic droplets that can be at least partially solidified, e.g., to form colloidal particles. In some embodiments, particles comprising an at least partially solid outer phase encapsulating an inner phase are formed. The inner phase may be any phase, e.g., a solid, a liquid, or a gas. In some cases, solidifying at least a portion of the outer phase of the droplets to form particles may increase the stability of the particles and/or the colloidal system containing the particles. In one set of embodiments, melting or liquefying the outer phase of the particles (for example, by heating the particle to a temperature above a threshold temperature) can allow release of an agent contained within the inner phase, and/or allow the inner phase to coalesce with a phase external to the particles. The melting temperature of the outer phase can be controlled in some embodiments such that the outer phase will melt above a predetermined temperature. In some embodiments, the particles may be formed to be essentially free of an auxiliary stabilizing agent. In some embodiments, an agent may be encapsulated within a particle with relatively high efficiency. Other aspects of the invention are generally directed to methods of making and using such colloidal systems, e.g., containing such particles, kits involving such colloidal systems, or the like.
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Inventors:
SHUM HO CHEUNG (US)
SUN BINGJIE (CN)
WEITZ DAVID A (US)
HOLTZE CHRISTIAN (DE)
SUN BINGJIE (CN)
WEITZ DAVID A (US)
HOLTZE CHRISTIAN (DE)
Application Number:
PCT/US2011/028754
Publication Date:
June 07, 2012
Filing Date:
March 17, 2011
Export Citation:
Assignee:
HARVARD COLLEGE (US)
BASF SE (DE)
SHUM HO CHEUNG (US)
SUN BINGJIE (CN)
WEITZ DAVID A (US)
HOLTZE CHRISTIAN (DE)
BASF SE (DE)
SHUM HO CHEUNG (US)
SUN BINGJIE (CN)
WEITZ DAVID A (US)
HOLTZE CHRISTIAN (DE)
International Classes:
B01J13/00; A01N25/28; A61K9/50; B01J13/04; C09B67/00; C11D3/50; C11D17/00
Domestic Patent References:
| WO2008121342A2 | 2008-10-09 | |||
| WO2008109176A2 | 2008-09-12 | |||
| WO2009048532A2 | 2009-04-16 |
Other References:
EDITH C. ROJAS ET AL: "Induction of Instability in Water-in-Oil-in-Water Double Emulsions by Freeze-Thaw Cycling", LANGMUIR, vol. 23, no. 13, 1 June 2007 (2007-06-01), pages 6911 - 6917, XP055011799, ISSN: 0743-7463, DOI: 10.1021/la063533f
J. GUERY ET AL: "Diffusion through colloidal shells under stress", PHYSICAL REVIEW E, vol. 79, no. 6, 1 June 2009 (2009-06-01), XP055012516, ISSN: 1539-3755, DOI: 10.1103/PhysRevE.79.060402
MAGDASSI S ET AL: "Formation of water/oil/water multiple emulsions with solid oil phase", JOURNAL OF COLLOID AND INTERFACE SCIENCE, ACADEMIC PRESS, NEW YORK, NY, US, vol. 120, no. 2, 1 December 1987 (1987-12-01), pages 537 - 539, XP024209040, ISSN: 0021-9797, [retrieved on 19871201], DOI: 10.1016/0021-9797(87)90381-X
BING JIE SUN ET AL: "Microfluidic Melt Emulsification for Encapsulation and Release of Actives", A C S APPLIED MATERIALS AND INTERFACES, AMERICAN CHEMICAL SOCIETY, US, vol. 2, no. 12, 22 December 2010 (2010-12-22), pages 3411 - 3416, XP008145173, ISSN: 1944-8244, [retrieved on 20101117], DOI: 10.1021/AM100860B
EDITH C. ROJAS ET AL: "Temperature-Induced Protein Release from Water-in-Oil-in-Water Double Emulsions", LANGMUIR, vol. 24, no. 14, 1 July 2008 (2008-07-01), pages 7154 - 7160, XP055012514, ISSN: 0743-7463, DOI: 10.1021/la703974n
J. GUERY ET AL: "Diffusion through colloidal shells under stress", PHYSICAL REVIEW E, vol. 79, no. 6, 1 June 2009 (2009-06-01), XP055012516, ISSN: 1539-3755, DOI: 10.1103/PhysRevE.79.060402
MAGDASSI S ET AL: "Formation of water/oil/water multiple emulsions with solid oil phase", JOURNAL OF COLLOID AND INTERFACE SCIENCE, ACADEMIC PRESS, NEW YORK, NY, US, vol. 120, no. 2, 1 December 1987 (1987-12-01), pages 537 - 539, XP024209040, ISSN: 0021-9797, [retrieved on 19871201], DOI: 10.1016/0021-9797(87)90381-X
BING JIE SUN ET AL: "Microfluidic Melt Emulsification for Encapsulation and Release of Actives", A C S APPLIED MATERIALS AND INTERFACES, AMERICAN CHEMICAL SOCIETY, US, vol. 2, no. 12, 22 December 2010 (2010-12-22), pages 3411 - 3416, XP008145173, ISSN: 1944-8244, [retrieved on 20101117], DOI: 10.1021/AM100860B
EDITH C. ROJAS ET AL: "Temperature-Induced Protein Release from Water-in-Oil-in-Water Double Emulsions", LANGMUIR, vol. 24, no. 14, 1 July 2008 (2008-07-01), pages 7154 - 7160, XP055012514, ISSN: 0743-7463, DOI: 10.1021/la703974n
Attorney, Agent or Firm:
OYER, Timothy, J. (Greenfield & Sack P.C.,600 Atlantic Avenu, Boston MA, US)
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