Title:
MEMBRANE ACTIVE POLYMERS
Document Type and Number:
WIPO Patent Application WO2004070019
Kind Code:
A3
Abstract:
We describe a class of polymaleic anhydride polymers capable of disrupting cell membranes. Co-delivery of these polymers with biologically active compounds increases cellular cytoplasmic delivery of the compounds.
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Inventors:
ROZEMA DAVID (US)
WAKEFIELD DARREN (US)
WAKEFIELD DARREN (US)
Application Number:
PCT/US2004/003573
Publication Date:
April 14, 2005
Filing Date:
January 30, 2004
Export Citation:
Assignee:
MIRUS CORP (US)
ROZEMA DAVID (US)
WAKEFIELD DARREN (US)
ROZEMA DAVID (US)
WAKEFIELD DARREN (US)
International Classes:
A61K9/14; A61K47/48; C08G63/48; C08G63/91; C08L51/06; C12N15/87; C12N; (IPC1-7): C08L51/06; C12N15/87
Foreign References:
| US4732933A | 1988-03-22 | |||
| US6436905B1 | 2002-08-20 |
Other References:
DUNCAN R.: "The dawning era of polymer therapeutics", NATURE REVIEWS DRUG DISCOVERY, vol. 2, no. 5, May 2003 (2003-05-01), pages 347 - 360, XP008034297
TSIOURVAS D. ET AL.: "Further studies on homopolymers and copolymers resulting from the reaction of polymaleic anhydride with alcohols and amines", JOURNAL OF POLYMER SCIENCE, vol. 28, 1990, pages 1263 - 1271, XP002985433
TSIOURVAS D. ET AL.: "Further studies on homopolymers and copolymers resulting from the reaction of polymaleic anhydride with alcohols and amines", JOURNAL OF POLYMER SCIENCE, vol. 28, 1990, pages 1263 - 1271, XP002985433
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