Title:
MEMBRANE-ASSOCIATED ORGANIZATIONAL PROTEINS
Document Type and Number:
WIPO Patent Application WO2000018915
Kind Code:
A3
Abstract:
The invention provides human membrane-associated organizational proteins (HJNCT) and polynucleotides which identify and encode HJNCT. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HJNCT.
Inventors:
YUE HENRY (US)
LAL PREETI (US)
CORLEY NEIL C (US)
GUEGLER KARL J (US)
BAUGHN MARIAH R (US)
LU AINA D (US)
TANG Y TOM (US)
LAL PREETI (US)
CORLEY NEIL C (US)
GUEGLER KARL J (US)
BAUGHN MARIAH R (US)
LU AINA D (US)
TANG Y TOM (US)
Application Number:
PCT/US1999/022082
Publication Date:
July 27, 2000
Filing Date:
September 23, 1999
Export Citation:
Assignee:
INCYTE PHARMA INC (US)
YUE HENRY (US)
LAL PREETI (US)
CORLEY NEIL C (US)
GUEGLER KARL J (US)
BAUGHN MARIAH R (US)
LU AINA D (US)
TANG Y TOM (US)
YUE HENRY (US)
LAL PREETI (US)
CORLEY NEIL C (US)
GUEGLER KARL J (US)
BAUGHN MARIAH R (US)
LU AINA D (US)
TANG Y TOM (US)
International Classes:
C12N15/09; A61K38/00; A61K45/00; A61P1/00; A61P1/04; A61P3/00; A61P3/08; A61P13/00; A61P13/12; A61P25/00; A61P29/00; A61P35/00; A61P37/00; A61P43/00; C07K14/47; C07K14/705; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/12; C12P21/02; C12Q1/68; (IPC1-7): C12N15/12; A61K38/17; C07K14/705; C07K16/28
Domestic Patent References:
| WO1998040407A1 | 1998-09-17 |
Other References:
J.E. LAMERDIN ET AL.: "R27090_3", EBI, 1 January 1998 (1998-01-01), Hinxton, Cambridge, UK, XP002129737
M. FURUSE ET AL.: "Claudin-1 and -2: Novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin", J. CELL BIOL., vol. 141, no. 7, 29 June 1998 (1998-06-29), ROCKEFELLER UNIVERSITY PRESS,NY,US;, pages 1539 - 1550, XP002129738
J.J. GROOTJANS ET AL.: "Syntenin, a PDZ protein that binds syndecan cytoplasmic domains", PROC. NATL. ACAD. SCI., vol. 94, December 1997 (1997-12-01), NATL. ACAD. SCI.,WASHINGTON,DC,US;, pages 13683 - 13688, XP002084504
J.C. TU ET AL.: "Homer binds a novel proline-rich motif and links group 1 medabotropic glutamate receptors with IP3 receptors", NEURON, vol. 21, no. 4, October 1998 (1998-10-01), CELL PRESS,CAMBRIDGE, MA,USA, pages 717 - 726, XP000857914
B.XIAO ET AL.: "Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins", NEURON, vol. 21, no. 4, October 1998 (1998-10-01), CELL PRESS,CAMBRIDGE, MA,USA, pages 707 - 716, XP000857915
M. FURUSE ET AL.: "Claudin-1 and -2: Novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin", J. CELL BIOL., vol. 141, no. 7, 29 June 1998 (1998-06-29), ROCKEFELLER UNIVERSITY PRESS,NY,US;, pages 1539 - 1550, XP002129738
J.J. GROOTJANS ET AL.: "Syntenin, a PDZ protein that binds syndecan cytoplasmic domains", PROC. NATL. ACAD. SCI., vol. 94, December 1997 (1997-12-01), NATL. ACAD. SCI.,WASHINGTON,DC,US;, pages 13683 - 13688, XP002084504
J.C. TU ET AL.: "Homer binds a novel proline-rich motif and links group 1 medabotropic glutamate receptors with IP3 receptors", NEURON, vol. 21, no. 4, October 1998 (1998-10-01), CELL PRESS,CAMBRIDGE, MA,USA, pages 717 - 726, XP000857914
B.XIAO ET AL.: "Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins", NEURON, vol. 21, no. 4, October 1998 (1998-10-01), CELL PRESS,CAMBRIDGE, MA,USA, pages 707 - 716, XP000857915
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