Title:
MEMBRANE PROTEIN POLYPEPTIDE HAVING FUNCTION OF SUPPORTING PRE-B CELL GROWTH AND GENE THEREFOR
Document Type and Number:
WIPO Patent Application WO/1995/010536
Kind Code:
A1
Abstract:
The invention relates to a gene coding for a novel membrane protein polypeptide having the function of supporting pre-B cell growth, a novel membrane protein polypeptide having the function of supporting pre-B cell growth and bearing the whole or part of the sequence comprising 180 amino acid residues, a process for producting the novel polypeptide by transforming host cells with a vector containing the above gene and culturing the transformant thus obtained, and a monoclonal antibody that recognizes the novel polypeptide. The above gene codes for a membrane protein having the function of supporting pre-B cell growth. The invention process permits mass production of a novel uniform membrane protein polypeptide and production of also a monoclonal antibody that recognizes the polypeptide. Thus it is possible to prepare a reagent for the identification and clinical diagnosis of rheumatoid arthritis (RA).
Inventors:
HIRANO TOSHIO (JP)
KAISHO TSUNEYASU (JP)
KAISHO TSUNEYASU (JP)
Application Number:
PCT/JP1994/001732
Publication Date:
April 20, 1995
Filing Date:
October 14, 1994
Export Citation:
Assignee:
HIRANO TOSHIO (JP)
KAISHO TSUNEYASU (JP)
KAISHO TSUNEYASU (JP)
International Classes:
C07K14/52; C07K14/705; C12N15/12; C12N15/19; C12P21/08; A61K39/00; (IPC1-7): C07K14/00; C12N15/00; C12N5/00; C12P21/02; C12P21/08
Other References:
KAISHO T, ET AL: "Human Bone Marrow Stromal Cell Lines from Myeloma and Rheumatoid Arthritis that can Support Murine Pre-B Cell Growth", THE JOURNAL OF IMMUNOLOGY, THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, vol. 149, no. 12, 15 December 1992 (1992-12-15), US, pages 4088 - 4095, XP002998620, ISSN: 0022-1767
KAISHO T, ET AL: "Bst-1, a Surface Molecule of Bone Marrow Stromal Cell Lines that Facilitates Pre-B Cell Growth", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 91, 1 June 1994 (1994-06-01), US, pages 5325 - 5329, XP002998621, ISSN: 0027-8424, DOI: 10.1073/pnas.91.12.5325
See also references of EP 0733643A4
KAISHO T, ET AL: "Bst-1, a Surface Molecule of Bone Marrow Stromal Cell Lines that Facilitates Pre-B Cell Growth", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 91, 1 June 1994 (1994-06-01), US, pages 5325 - 5329, XP002998621, ISSN: 0027-8424, DOI: 10.1073/pnas.91.12.5325
See also references of EP 0733643A4
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