Title:
MEMBRANE SURFACE PROTEIN CONTAINING GPI ANCHOR REGION
Document Type and Number:
WIPO Patent Application WO/2023/088246
Kind Code:
A1
Abstract:
Provided is a membrane surface protein containing a GPI anchor region. Specifically, provided are a fusion protein comprising a functional domain and a GPI anchor region, and the use thereof. The fusion protein can effectively activate and proliferate immune cells, and improve the effector function of immune cells.
Inventors:
JIN HUAJUN (CN)
ZHOU YING (CN)
WANG CHAO (CN)
HUANG CHEN (CN)
ZHOU YING (CN)
WANG CHAO (CN)
HUANG CHEN (CN)
Application Number:
PCT/CN2022/131974
Publication Date:
May 25, 2023
Filing Date:
November 15, 2022
Export Citation:
Assignee:
SHANGHAI JUNCELL THERAPEUTICS CO LTD (CN)
International Classes:
A61K48/00; C12N15/10; C07K14/705
Domestic Patent References:
| WO2021178701A1 | 2021-09-10 |
Foreign References:
| CN111479921A | 2020-07-31 | |||
| CN1544637A | 2004-11-10 |
Other References:
MUENCHMEIER, N. ET AL.: "A Novel CXCL10-Based GPI-Anchored Fusion Protein as Adjuvant in NK-Based Tumor Therapy", PLOS ONE, vol. 8, no. 8, 30 August 2013 (2013-08-30), XP055963216, DOI: 10.1371/journal.pone.0072749
SAHA SUVRAJIT, LEE IL-HYUNG, POLLEY ANIRBAN, GROVES JAY T., RAO MADAN, MAYOR SATYAJIT: "Diffusion of GPI-anchored proteins is influenced by the activity of dynamic cortical actin", MOLECULAR BIOLOGY OF THE CELL, AMERICAN SOCIETY FOR CELL BIOLOGY, US, vol. 26, no. 22, 5 November 2015 (2015-11-05), US , pages 4033 - 4045, XP093068254, ISSN: 1059-1524, DOI: 10.1091/mbc.E15-06-0397
LIU, JING ET AL.: "Influenza virus-like particles composed of conserved influenza proteins and GPI-anchored CCL28/GM-CSF fusion proteins enhance protective immunity against homologous and heterologous viruses", INTERNATIONAL IMMUNOPHARMACOLOGY, vol. 63, 31 December 2018 (2018-12-31), pages 119 - 128, XP085460378, DOI: 10.1016/j.intimp.2018.07.011
SAHA SUVRAJIT, LEE IL-HYUNG, POLLEY ANIRBAN, GROVES JAY T., RAO MADAN, MAYOR SATYAJIT: "Diffusion of GPI-anchored proteins is influenced by the activity of dynamic cortical actin", MOLECULAR BIOLOGY OF THE CELL, AMERICAN SOCIETY FOR CELL BIOLOGY, US, vol. 26, no. 22, 5 November 2015 (2015-11-05), US , pages 4033 - 4045, XP093068254, ISSN: 1059-1524, DOI: 10.1091/mbc.E15-06-0397
LIU, JING ET AL.: "Influenza virus-like particles composed of conserved influenza proteins and GPI-anchored CCL28/GM-CSF fusion proteins enhance protective immunity against homologous and heterologous viruses", INTERNATIONAL IMMUNOPHARMACOLOGY, vol. 63, 31 December 2018 (2018-12-31), pages 119 - 128, XP085460378, DOI: 10.1016/j.intimp.2018.07.011
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (CN)
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