Title:
MEMORY INVARIANT NKT CELL MARKER
Document Type and Number:
WIPO Patent Application WO/2016/013672
Kind Code:
A1
Abstract:
The present invention provides a use of KLRG1 as a marker specific to a memory invariant NKT cell. A memory invariant NKT cell can be detected or isolated easily using an antibody capable of recognizing KLRG1 specifically.
Inventors:
FUJII SHIN-ICHIRO (JP)
SHIMIZU KANAKO (JP)
OHARA OSAMU (JP)
WATANABE TAKASHI (JP)
SHIMIZU KANAKO (JP)
OHARA OSAMU (JP)
WATANABE TAKASHI (JP)
Application Number:
PCT/JP2015/071157
Publication Date:
January 28, 2016
Filing Date:
July 24, 2015
Export Citation:
Assignee:
RIKEN (JP)
International Classes:
G01N33/53; C12N5/0783; C12Q1/04; C12Q1/24; C07K14/725; C07K16/28
Domestic Patent References:
| WO2013063395A1 | 2013-05-02 |
Foreign References:
| JP2010083863A | 2010-04-15 | |||
| US20110004953A1 | 2011-01-06 | |||
| JP2013034459A | 2013-02-21 |
Other References:
NAOKI MATSUMOTO: "NK Saibo no Saibo Ninshiki Kiko to Shikkan Hi MHC Class I Bunshi o Ligand to suru NK Saibo Yokuseisei Receptor KLRG1 to LAIR-1", EXPERIMENTAL MEDICINE, vol. 25, no. 9, 2007, pages 1293 - 1300, XP008185385
ARRUNATEGUI-CORREA, VICTOR ET AL.: "Induction of expression of KLRG1 on NKT cells and conventional CD 4+ and CD 8 alpha+T cells in on- lymphoid tissues after oral Listeria monocytogenes infection.", GASTROENTEROLOGY, vol. 126, no. 4, 2004, pages A294, XP008185355
BEYERSDORF N B ET AL.: "Expression of inhibitory ''killer cell lectin-like receptor G1'' identifies unique subpopulations of effector and memory CD 8 T cells", EUR J IMMUNOL, vol. 31, no. 12, 2001, pages 3443 - 3452, XP055389214
SHIMIZU, KANAKO ET AL.: "Invariant NKT Cells Induce Plasmacytoid Dendritic Cell (DC) Cross- Talk with Conventional DCs for Efficient Memory CD 8+ T Cell Induction", JOURNAL OF IMMUNOLOGY, vol. 190, no. 11, 2013, pages 5609 - 5619, XP055389217
MALAISE MURIEL ET AL.: "KLRG1+ NK Cells Protect T-bet-Deficient Mice from Pulmonary Metastatic Colorectal Carcinoma", J IMMUNOL, vol. 192, no. 4, 15 February 2014 (2014-02-15), pages 1954 - 1961, XP055389220
KONSTA E ET AL.: "FLOW CYTOMETRY PROTOCOL OF NK AND NKT CELLS VALIDATION", CLIN CHEM LAB MED, vol. 48, no. 9, 2010, pages A169, XP008185352
SHIMIZU KANAKO ET AL.: "KLRG+ invariant natural killer T cells are long-lived effectors", PROC NATL ACAD SCI USA, vol. 111, no. 34, 26 August 2014 (2014-08-26), pages 12474 - 12479, XP055389235
See also references of EP 3190415A4
ARRUNATEGUI-CORREA, VICTOR ET AL.: "Induction of expression of KLRG1 on NKT cells and conventional CD 4+ and CD 8 alpha+T cells in on- lymphoid tissues after oral Listeria monocytogenes infection.", GASTROENTEROLOGY, vol. 126, no. 4, 2004, pages A294, XP008185355
BEYERSDORF N B ET AL.: "Expression of inhibitory ''killer cell lectin-like receptor G1'' identifies unique subpopulations of effector and memory CD 8 T cells", EUR J IMMUNOL, vol. 31, no. 12, 2001, pages 3443 - 3452, XP055389214
SHIMIZU, KANAKO ET AL.: "Invariant NKT Cells Induce Plasmacytoid Dendritic Cell (DC) Cross- Talk with Conventional DCs for Efficient Memory CD 8+ T Cell Induction", JOURNAL OF IMMUNOLOGY, vol. 190, no. 11, 2013, pages 5609 - 5619, XP055389217
MALAISE MURIEL ET AL.: "KLRG1+ NK Cells Protect T-bet-Deficient Mice from Pulmonary Metastatic Colorectal Carcinoma", J IMMUNOL, vol. 192, no. 4, 15 February 2014 (2014-02-15), pages 1954 - 1961, XP055389220
KONSTA E ET AL.: "FLOW CYTOMETRY PROTOCOL OF NK AND NKT CELLS VALIDATION", CLIN CHEM LAB MED, vol. 48, no. 9, 2010, pages A169, XP008185352
SHIMIZU KANAKO ET AL.: "KLRG+ invariant natural killer T cells are long-lived effectors", PROC NATL ACAD SCI USA, vol. 111, no. 34, 26 August 2014 (2014-08-26), pages 12474 - 12479, XP055389235
See also references of EP 3190415A4
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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