MESENCHYMAL STEM CELL EXPRESSING HEPATOCYTE GROWTH FACTOR, AND USE THEREOF

WIPO Patent Application WO/2017/135795

A1

The present invention relates to: a recombinant lentivirus vector comprising a gene encoding a hepatocyte growth factor (HGF) protein; and a cell that is transfected with the lentivirus produced by using the vector. The recombinant lentivirus of the present invention comprises a gene encoding a HGF protein, and a host cell transfected with the lentivirus maintains a high cell proliferation rate. Thus, a mesenchymal stem cell expressing HGF by being transfected with the lentivirus may be usefully employed as a cell therapeutic agent.

SUNG YOUNG CHUL (KR)
LEE SOON MIN (KR)
KIM HEY-YON (KR)

PCT/KR2017/001301

August 10, 2017

February 06, 2017

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SLBIGEN INC (KR)

C12N15/86; A61K35/28; C07K14/475; C12N5/0775

KR20140146062A	2014-12-24
KR100562824B1	2006-03-23

ZHU XIAOYU ET AL: "Establishment of a lentiviral vector encoding human HGF and the infection of human ADSCs", BIOMED RESEARCH INTERNATIONAL, vol. 2013, 2013, pages 1 - 8, XP055594990, ISSN: 2314-6133, DOI: doi:10.1155/2013/724896
ZHANG: "Construction of lentivirus vector carrying HGF and exploration of transfection condition of rat adipocyte-derived mesenchymal stem cells", JOURNAL OF EXPERIMENTAL HEMATOLOGY, April 2015 (2015-04-01), pages 490 - 494
TSUJI: "Adipose-derived stem cells: Implications in tissue regeneration", WORLD JOURNAL OF STEM CELLS, 26 July 2014 (2014-07-26), pages 312 - 321
DATABASE NCBI 30 September 2015 (2015-09-30), Database accession no. XP 003822790 .1

FIRSTLAW P.C. (KR)

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