Title:
MESENCHYMAL STEM CELLS GENETICALLY ENGINEERED TO EXPRESS PEDF, OR OVEREXPRESS PEDF IN COMPARISON TO PARENTAL CELLS
Document Type and Number:
WIPO Patent Application WO/2021/002676
Kind Code:
A1
Abstract:
Disclosed are mesenchymal stem cells genetically engineered to express pigment epithelium-derived factor (PEDF), or overexpress PEDF in comparison to parental cells. According to one embodiment, a pharmaceutical composition and a health functional food, which comprise same, can be effectively used in the prevention, alleviation or treatment of damage to epithelial cells or aging-associated diseases, retinal diseases, or liver diseases.
Inventors:
KIM GI JIN (KR)
PARK SO HAE (KR)
KIM JAE YEON (KR)
PARK SO HAE (KR)
KIM JAE YEON (KR)
Application Number:
PCT/KR2020/008602
Publication Date:
January 07, 2021
Filing Date:
July 01, 2020
Export Citation:
Assignee:
UNIV CHA IND ACAD COOP FOUND (KR)
SUNGKWANG MEDICAL FOUND (KR)
SUNGKWANG MEDICAL FOUND (KR)
International Classes:
C12N5/0775; A23L33/10; A61P1/16; A61P27/02
Domestic Patent References:
| WO2018045914A1 | 2018-03-15 |
Foreign References:
| KR20160045933A | 2016-04-27 | |||
| KR20140096368A | 2014-08-05 |
Other References:
EK EUGENE T H ET AL: "Pigment epithelium-derived factor: a multimodal tumor inhibitor.", MOLECULAR CANCER THERAPEUTICS, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 5, no. 7, 1 July 2006 (2006-07-01), US, pages 1641 - 1646, XP002457590, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-06-0107
MINA ELAHY, SWATI BAINDUR-HUDSON, AND CRISPIN R. DASS: "The Emerging Role of PEDF in Stem Cell Biology", JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, vol. 2012, 1 January 2012 (2012-01-01), pages 1 - 6, XP002681871, ISSN: 1110-7243, DOI: 10.1155/2012/239091
MINA ELAHY, SWATI BAINDUR-HUDSON, AND CRISPIN R. DASS: "The Emerging Role of PEDF in Stem Cell Biology", JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, vol. 2012, 1 January 2012 (2012-01-01), pages 1 - 6, XP002681871, ISSN: 1110-7243, DOI: 10.1155/2012/239091
Attorney, Agent or Firm:
Y.P.LEE, MOCK & PARTNERS (KR)
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