Title:
MESENCHYMAL STEM CELLS HAVING ENHANCED OSTEOGENIC DIFFERENTIATION CAPACITY, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/234998
Kind Code:
A1
Abstract:
Mesenchymal stem cells having enhanced osteogenic differentiation capacity according to one aspect have excellent osteogenic differentiation capacity, adipocyte differentiation capacity, chondrocyte differentiation capacity, and nerve cell differentiation capacity, and in particular, have osteogenic differentiation capacity that is remarkably superior to that of mesenchymal stem cells derived from other sources. In addition, the mesenchymal stem cells having enhanced osteogenic differentiation capacity have a low risk of immune rejection reaction and can exhibit a prevention or treatment effect on bone diseases and estrogen deficiency syndrome. Further, the mesenchymal stem cells having enhanced osteogenic differentiation capacity maintain the ability to proliferate even in continuous subculturing, and maintain nuclear stability, and thus have the advantages of being safe for commercialization and able to be mass-produced.
Inventors:
RIM JONG SEOP (KR)
KONG TAEHO (KR)
WON JIHYE (KR)
KIM JUNSUNG (KR)
LEE SOONCHUL (KR)
AN BO RIM (KR)
KONG TAEHO (KR)
WON JIHYE (KR)
KIM JUNSUNG (KR)
LEE SOONCHUL (KR)
AN BO RIM (KR)
Application Number:
PCT/KR2022/005913
Publication Date:
November 10, 2022
Filing Date:
April 26, 2022
Export Citation:
Assignee:
SUNGKWANG MEDICAL FOUND (KR)
International Classes:
C12N5/0775; A23L33/10; A61K35/28; A61P19/00
Domestic Patent References:
| WO2020161748A1 | 2020-08-13 | |||
| WO2013082543A1 | 2013-06-06 |
Foreign References:
| KR20180094800A | 2018-08-24 | |||
| KR20210059516A | 2021-05-25 |
Other References:
BÖHM ANNA-MAREI; DIRCKX NAOMI; TOWER ROBERT J; PEREDO NICOLAS; VANUYTVEN SEBASTIAAN; THEUNIS KOEN; NEFYODOVA ELENA; CARDOEN RUBEN;: "Activation of Skeletal Stem and Progenitor Cells for Bone Regeneration Is Driven by PDGFRβ Signaling", DEVELOPMENTAL CELL, vol. 51, no. 2, 19 September 2019 (2019-09-19), US , pages 236, XP085873292, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2019.08.013
D'CRUZ ROSHAN J., CURRIER ARTHUR W., SAMPSON VALERIE B.: "Laboratory Testing Methods for Novel Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2)", FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, vol. 8, 4 June 2020 (2020-06-04), CH , pages 1 - 11, XP055835615, ISSN: 2296-634X, DOI: 10.3389/fcell.2020.00468
D'CRUZ ROSHAN J., CURRIER ARTHUR W., SAMPSON VALERIE B.: "Laboratory Testing Methods for Novel Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2)", FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, vol. 8, 4 June 2020 (2020-06-04), CH , pages 1 - 11, XP055835615, ISSN: 2296-634X, DOI: 10.3389/fcell.2020.00468
Attorney, Agent or Firm:
Y.P.LEE, MOCK & PARTNERS (KR)
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