Title:
MESENCHYMAL STEM CELLS FOR IN VITRO MODELING AND CELL-BASED THERAPY OF HUMAN DISEASES AND BANKS THEREOF
Document Type and Number:
WIPO Patent Application WO/2013/124815
Kind Code:
A3
Abstract:
A method of qualifying a mesenchymal stem cell (MSC) population is disclosed. The method comprises: (a) ex vivo differentiating a population of mesenchymal stem cells originating from the subject towards a first lineage - specific cell, the first lineage - specific cell being associated with a brain disease; (b) ex vivo differentiating a population of mesenchymal stem cells originating from a healthy subject towards the first lineage - specific cell; (c) comparing an effect of the first lineage specific cell derived from the subject with an effect of the first lineage specific cell derived from the healthy subject on a second lineage specific cell associated with the brain disease, wherein a difference in the effect above or below a predetermined level is indicative of a qualification of a mesenchymal stem cell population for cell therapy of said brain disease.
Inventors:
BRODIE CHAYA (US)
SLAVIN SHIMON (IL)
SLAVIN SHIMON (IL)
Application Number:
PCT/IB2013/051428
Publication Date:
October 31, 2013
Filing Date:
February 21, 2013
Export Citation:
Assignee:
BRAINSTEM BIOTEC LTD (IL)
International Classes:
A61P25/00; G01N33/68; C12N5/0775; G01N33/50
Domestic Patent References:
| WO2011030336A1 | 2011-03-17 |
Foreign References:
| US20110311984A1 | 2011-12-22 |
Other References:
ZHANG ZHIQING ET AL: "Isolation and characterization of mesenchymal stem cells derived from bone marrow of patients with Parkinson's disease", IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY - ANIMAL, vol. 44, no. 5-6, June 2008 (2008-06-01), pages 169 - 177, XP055074787, ISSN: 1071-2690, DOI: 10.1007/s11626-008-9093-1
KARAÖZ E ET AL: "Human dental pulp stem cells demonstrate better neural and epithelial stem cell properties than bone marrow-derived mesenchymal stem cells", HISTOCHEMISTRY AND CELL BIOLOGY, vol. 136, no. 4, 31 October 2011 (2011-10-31), pages 455 - 473, XP055074788, ISSN: 0948-6143, DOI: 10.1007/s00418-011-0858-3
GONG MIN ET AL: "Immortalized mesenchymal stem cells: an alternative to primary mesenchymal stem cells in neuronal differentiation and neuroregeneration associated studies", JOURNAL OF BIOMEDICAL SCIENCE, vol. 18, no. 1, 25 November 2011 (2011-11-25), pages 87, XP021111456, ISSN: 1423-0127, DOI: 10.1186/1423-0127-18-87
KARAÖZ E ET AL: "Human dental pulp stem cells demonstrate better neural and epithelial stem cell properties than bone marrow-derived mesenchymal stem cells", HISTOCHEMISTRY AND CELL BIOLOGY, vol. 136, no. 4, 31 October 2011 (2011-10-31), pages 455 - 473, XP055074788, ISSN: 0948-6143, DOI: 10.1007/s00418-011-0858-3
GONG MIN ET AL: "Immortalized mesenchymal stem cells: an alternative to primary mesenchymal stem cells in neuronal differentiation and neuroregeneration associated studies", JOURNAL OF BIOMEDICAL SCIENCE, vol. 18, no. 1, 25 November 2011 (2011-11-25), pages 87, XP021111456, ISSN: 1423-0127, DOI: 10.1186/1423-0127-18-87
Attorney, Agent or Firm:
G. E. EHRLICH (1995) LTD. et al. (04 Ramat Gan, IL)
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