Title:
MESENCHYMAL STEM CELLS THAT HIGHLY EXPRESS AT LEAST ONE CELL SURFACE MARKER SELECTED FROM GROUP CONSISTING OF EGFR AND MIC-AB AND FORMULATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION CONTAINING SAID MESENCHYMAL STEM CELLS AND FORMULATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2017/170925
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide novel mesenchymal stem cells which exhibit a superior therapeutic effect on various diseases, a novel pharmaceutical composition containing the mesenchymal stem cells, and methods for formulating the cells and the composition. The mesenchymal stem cells according to the present invention highly express at least one cell surface marker selected from the group consisting of EGFR and MIC-AB. The mesenchymal stem cells which highly express the specific marker are positive for CD29, CD73, CD90, CD105, and CD166, and maintain an undifferentiated state.
Inventors:
IKEYAMA YOSHIFUMI (JP)
TSUDA TOMOHIRO (JP)
UNO EIKO (JP)
YUMOTO MASAYO (JP)
YOSHINO MIHOKO (JP)
TSUDA TOMOHIRO (JP)
UNO EIKO (JP)
YUMOTO MASAYO (JP)
YOSHINO MIHOKO (JP)
Application Number:
PCT/JP2017/013389
Publication Date:
October 05, 2017
Filing Date:
March 30, 2017
Export Citation:
Assignee:
ROHTO PHARMA (JP)
International Classes:
C12N5/00
Domestic Patent References:
| WO2009054258A1 | 2009-04-30 |
Foreign References:
| JP2010532370A | 2010-10-07 | |||
| JP2015500018A | 2015-01-05 | |||
| JP2009060840A | 2009-03-26 | |||
| JP2013018756A | 2013-01-31 |
Other References:
LUCA, ANTONELLA DE ET AL.: "Role of the EGFR Ligand/Receptor System in the Secretion of Angiogenic Factors in Mesenchymal Stem Cells", JOURNAL OF CELLULAR PHYSIOLOGY, vol. 226, 2010, pages 2131 - 2138
LI, MINGFEN ET AL.: "Mesenchymal stem cells suppress CD 8+ T cell -mediated activation by suppressing natural killer group 2, member D protein receptor expression and secretion of prostaglandin E2, indoleamine 2, 3-dioxygenase and transforming growth factor-beta", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, vol. 178, 2014, pages 516 - 524
LI, MINGFEN ET AL.: "Mesenchymal stem cells suppress CD 8+ T cell -mediated activation by suppressing natural killer group 2, member D protein receptor expression and secretion of prostaglandin E2, indoleamine 2, 3-dioxygenase and transforming growth factor-beta", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, vol. 178, 2014, pages 516 - 524
Attorney, Agent or Firm:
TSUKUNI & ASSOCIATES et al. (JP)
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