Title:
METABOLIC CHECKPOINT-BASED HUMAN SERUM ALBUMIN NANO-DRUG, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/104021
Kind Code:
A1
Abstract:
A metabolic checkpoint-based human serum albumin nano-drug (IDNPs), and a preparation method therefor and an application thereof. A prodrug molecule IDOi-DON obtained by coupling an indoleamine-2,3-dioxygenase inhibitor (IDOi) and a metabolic reprogramming agent DON by means of a chemical bond amidation reaction can be subjected to enzymatic cleavage in a tumor microenvironment, and the outer surface is coated with natural biocompatible serum albumin. The drug stability is improved, the toxic and side effects of the drug are reduced, the drug is enriched at a tumor site, the effects of inhibiting the IDO activity of tumor cells and inhibiting Treg cell proliferation while activating CD8+T cells are achieved by a synergistic effect of two drugs, and the anti-tumor immunotherapy effect is synergistically enhanced.
Inventors:
CAI LINTAO (CN)
HUANG GUOJUN (CN)
PAN HONG (CN)
ZHENG MINGBIN (CN)
TANG XIAOFAN (CN)
LIAO JIANHONG (CN)
WANG MENGMENG (CN)
ZHANG BAOZHEN (CN)
HUANG GUOJUN (CN)
PAN HONG (CN)
ZHENG MINGBIN (CN)
TANG XIAOFAN (CN)
LIAO JIANHONG (CN)
WANG MENGMENG (CN)
ZHANG BAOZHEN (CN)
Application Number:
PCT/CN2022/136879
Publication Date:
June 15, 2023
Filing Date:
December 06, 2022
Export Citation:
Assignee:
SHENZHEN INST ADV TECH (CN)
International Classes:
A61K47/42; A61K31/405; A61K45/06; A61P35/00
Domestic Patent References:
| WO2022232565A1 | 2022-11-03 |
Foreign References:
| CN114306620A | 2022-04-12 | |||
| CN112920092A | 2021-06-08 | |||
| CN110585131A | 2019-12-20 | |||
| CN108295046A | 2018-07-20 | |||
| CN108348492A | 2018-07-31 | |||
| CN113677338A | 2021-11-19 |
Attorney, Agent or Firm:
BEIJING ZHONG XUN TONG DA INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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