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Title:
METAL COMPLEXES AND METHODS OF TREATMENT
Document Type and Number:
WIPO Patent Application WO/2015/070177
Kind Code:
A3
Abstract:
In one embodiment, the present application discloses compounds that are selective neuroactive agents for the treatment of diseases of the central nervous system (CNS). In one aspect, the neuroactive agents are NCDs of metal chelates, including complexes of iron, copper or zinc.

Inventors:
WARNER JOHN C (US)
CHERUKU SRINIVASA R (US)
HARI ANITHA (US)
NORMAN JAMES J (US)
Application Number:
PCT/US2014/064879
Publication Date:
October 08, 2015
Filing Date:
November 10, 2014
Export Citation:
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Assignee:
COLLABORATIVE MEDICINAL DEV LLC (US)
International Classes:
C07C337/08; A61K47/48
Domestic Patent References:
WO2010066010A12010-06-17
WO2008061306A12008-05-29
WO2004078163A22004-09-16
Other References:
MCQUADE P ET AL: "Investigation into <64>Cu-labeled Bis(selenosemicarbazone) and Bis(thiosemicarbazone) complexes as hypoxia imaging agents", NUCLEAR MEDICINE AND BIOLOGY, ELSEVIER, NY, US, vol. 32, no. 2, 1 February 2005 (2005-02-01), pages 147 - 156, XP027674854, ISSN: 0969-8051, [retrieved on 20050201]
JASON P. HOLLAND ET AL: "Functionalized Bis(thiosemicarbazonato) Complexes of Zinc and Copper: Synthetic Platforms Toward Site-Specific Radiopharmaceuticals", INORGANIC CHEMISTRY, vol. 46, no. 2, 1 January 2007 (2007-01-01), pages 465 - 485, XP055030122, ISSN: 0020-1669, DOI: 10.1021/ic0615628
PHILIP J. BLOWER ET AL: "Structural trends in copper(ii) bis(thiosemicarbazone) radiopharmaceuticals", DALTON TRANSACTIONS, no. 23, 1 January 2003 (2003-01-01), pages 4416, XP055208122, ISSN: 1477-9226, DOI: 10.1039/b307499d
Attorney, Agent or Firm:
MCGOWAN, Malcolm K. et al. (127 S. Peyton St. Ste. 20, Alexandria VA, US)
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