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Patent Searching and Data


Title:
METAL COMPLEXES FOR USE IN MEDICAL AND THERAPEUTIC APPLICATIONS
Document Type and Number:
WIPO Patent Application WO2002026748
Kind Code:
A3
Abstract:
The first aspect of the present invention relates to transition metal complexes having the formula (I) or (II) wherein M is a radioactive metal having a valence of +2, +3, +4, or +5; m<+> designates the charge of the metal complex, each R is independently C1-C8 linear or branched alkyl, a fifth ligand, and mixtures thereof; B is a bridging unit which comprises at least 2 carbon atoms; L is a pharmaceutically acceptable ligand; X is a pharmaceutically compatible anion in sufficient amount to provide electronic neutrality. The complexes of the present invention are suitable for use in diagnostic, therapeutic or radiotherapeutic or chemotherapeutic compositions for visualization, therapy, chemotherapy or radiotherapy of tissues or organs.

Inventors:
PERKINS CHRISTOPHER MARK
Application Number:
US0129262W
Publication Date:
June 27, 2002
Filing Date:
September 19, 2001
Export Citation:
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Assignee:
THE PROCTER & GAMBLE COMPANY
International Classes:
C07D487/08; A61K51/00; A61K51/04; A61P35/00; C07F1/08; C07F5/00; C07F7/00; C07F9/68; C07F11/00; C07F13/00; C07F15/00; C07F15/02; C07F15/04; C07F15/06; (IPC1-7): C07F1/08; A61K49/00; A61K31/30
Foreign References:
US5693324A1997-12-02
Other References:
BROAN, CHRISTOPHER ET AL: "Structure and solution stability of indium and gallium complexes of 1,4,7-triazacyclononanetriacetate and of yttrium complexes of 1,4,7,10-tetraazacyclododecanetetraacetate and related ligands: kinetically stable complexes for use in imaging and radioimmunotherapy. X-ray molecular structure of the i" J. CHEM. SOC., PERKIN TRANS. 2, no. 1, 1991, pages 87-99, XP001031171
HUBIN, TIMOTHY J. ET AL: "Ultra rigid cross-bridged tetraazamacrocycles as ligands-the challenge and the solution" CHEM. COMMUN. (CAMBRIDGE), no. 16, 1998, pages 1675-1676, XP001039648
WEISMAN, GARY R. ET AL: "Synthesis and transition-metal complexes of new cross-bridged tetraamine ligands" CHEM. COMMUN. (CAMBRIDGE) , no. 8, 1996, pages 947-948, XP001031187
COX, JONATHAN P. L. ET AL: "Synthesis of a kinetically stable yttrium-90 labeled macrocycle-antibody conjugate" J. CHEM. SOC., CHEM. COMMUN. , no. 12, 1989, pages 797-798, XP001031170
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