Title:
METAL-POLYPHENOL COMPLEX PARTICLE, DRUG-LIPID PARTICLE, METHOD FOR PREPARING SAME, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/032482
Kind Code:
A1
Abstract:
The present disclosure relates to the technical field of biopharmaceutics, and particularly provides a metal-polyphenol compound particle, a drug-lipid particle, a method for preparing same, and use thereof. The metal-polyphenol compound provided in the present disclosure serves as a drug carrier for drug stabilization, delivery and transportation and the like, and forms, together with other carriers, the metal-polyphenol complex particle for achieving effective administration of negatively-charged drugs. The complex can achieve efficient systemic drug delivery and, compared with LNP containing cationic lipids or ionizable lipids, has significantly reduced toxicity, achieving safe and effective treatment of diseases or conditions.
Inventors:
WANG SHAN (CN)
HU DUN (CN)
SUN YIYI (CN)
HU DUN (CN)
SUN YIYI (CN)
Application Number:
PCT/CN2023/111151
Publication Date:
February 15, 2024
Filing Date:
August 04, 2023
Export Citation:
Assignee:
HUNAN JIANRUI BIO TECH CO LTD (CN)
International Classes:
A61K47/52; A61K9/127; A61K47/69
Foreign References:
| CN112375748A | 2021-02-19 | |||
| CN112946294A | 2021-06-11 | |||
| CN107922471A | 2018-04-17 | |||
| CN113322354A | 2021-08-31 | |||
| CN1981044A | 2007-06-13 |
Other References:
CHEN ZHENHUA; YU TING; ZHOU BANGFEN; WEI JINHUAN; FANG YONG; LU JUN; GUO LING; CHEN WEI; LIU ZHI-PING; LUO JUNHANG: "Mg(II)-Catechin nanoparticles delivering siRNA targeting EIF5A2 inhibit bladder cancer cell growthin vitroandin vivo", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 81, 12 November 2015 (2015-11-12), AMSTERDAM, NL , pages 125 - 134, XP029381887, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2015.11.022
Attorney, Agent or Firm:
CHINA ZHENGHE INTELLECTUAL PROPERTY AGENCY (CN)
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