Title:
METALLICENIUM SALTS AND UTILIZATION THEREOF AS CYTOSTATIC AGENTS FOR COMBATTING CANCER
Document Type and Number:
WIPO Patent Application WO1985003507
Kind Code:
A3
Abstract:
PCT No. PCT/EP85/00047 Sec. 371 Date Oct. 3, 1985 Sec. 102(e) Date Oct. 3, 1985 PCT Filed Feb. 8, 1985 PCT Pub. No. WO85/03507 PCT Pub. Date Aug. 15, 1985.Metallicenium salts of the general formula I [( eta 5-C5H-xRx)M( eta 5-C5H5-yR'y)]am+[A]bn-(I) in which M is Fe, Co, Ni, Ru or Os; C5H5-xRx and C5H5-yR'y denote cyclopendadienyl rings which, independently of one another, can be unsubstituted (x and y=0) or mono-, di-, tri-, tetra- or penta-substituted (x and y=1, 2, 3, 4 or 5), and in which R and R' independently of one another represent identical or different substituents and denote alkyl, cycloalkyl, hydroxyalkyl, aminoalkyl, halogenoalkyl, alkenyl, aryl, aralkyl, ferrocenyl, ferrocenylium, ferrocenylalkyl, acyl, halogenyl, trialkylsilyl, tricycloalkylsilyl, triarylsilyl, triaralkylsilyl or carboxyl, ester, amide or hydrazide groups, or R and R' together form an alkylene bridge with 2 to 4 bridge atoms; a, b, m and n are integers, and m has the value 1 or 2, n has the value 1, 2 or 3 and axm=bxn; and A is a complexating or very bulky anion which stabilizes the metallicenium cation; and solvates of these salts, for use as medicaments, in paticular as cytostatics in combating tumors susceptible thereto.
Inventors:
KOEPF-MAIER PETRA (DE)
KOEPF HARTMUT (DE)
NEUSE EBERHARD WILHELM (DE)
KOEPF HARTMUT (DE)
NEUSE EBERHARD WILHELM (DE)
Application Number:
PCT/EP1985/000047
Publication Date:
September 26, 1985
Filing Date:
February 08, 1985
Export Citation:
Assignee:
KOEPF MAIER PETRA (DE)
KOEPF HARTMUT (DE)
NEUSE EBERHARD WILHELM (DE)
KOEPF HARTMUT (DE)
NEUSE EBERHARD WILHELM (DE)
International Classes:
A61K31/28; C07F17/00; A61K31/295; A61P35/00; C07F17/02; (IPC1-7): C07F17/02
Other References:
CHEMISCHE BERICHTE, Band 93, 1960, Weinheim, (DE) A.N. NESMEJANOW et al: "Unmittelbare Cyanierung der Ferriciniumsalze", Seiten 2729-2735
JOURNAL OF ORGANOMETALLIC CHEMISTRY, Band 60, (1973), Seiten c17,c18. Elsevier Sequoia S.A. Lausanne (CH) M. CASTAGNOLA et al: "The electron donor properteis of ferrocene. The oxidation of ferrocene by carboxylic acids"
CHEMICAL COMMUNICATIONS, 1965, London, (GB) M. ALY et al: "Paramagnetic ferrocene acid adducts. Kinetics of electron transfer to proton acids", Seiten 404-406
JOURNAL OF ORGANOMETALLIC CHEMISTRY, Band 60, (1973), Seiten c17,c18. Elsevier Sequoia S.A. Lausanne (CH) M. CASTAGNOLA et al: "The electron donor properteis of ferrocene. The oxidation of ferrocene by carboxylic acids"
CHEMICAL COMMUNICATIONS, 1965, London, (GB) M. ALY et al: "Paramagnetic ferrocene acid adducts. Kinetics of electron transfer to proton acids", Seiten 404-406
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