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Title:
METALLOINSERTOR COMPLEXES TARGETED TO DNA MISMATCHES
Document Type and Number:
WIPO Patent Application WO/2012/155004
Kind Code:
A3
Abstract:
A composition including a Rh or Ru metalloinsertor complex specifically targets mismatch repair (MMR)-deficient cells. Selective cytotoxicity is induced in MMR-deficient cells upon uptake of the inventive metalloinsertor complexes.

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Inventors:
BARTON JACQUELINE K (US)
KOMOR ALEXIS (US)
SCHNEIDER CURTIS J (US)
WEIDMANN ALYSON (US)
ERNST RUSSELL (US)
Application Number:
PCT/US2012/037403
Publication Date:
March 28, 2013
Filing Date:
May 10, 2012
Export Citation:
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Assignee:
CALIFORNIA INSITUTE OF TECHNOLOGY (US)
BARTON JACQUELINE K (US)
KOMOR ALEXIS (US)
SCHNEIDER CURTIS J (US)
WEIDMANN ALYSON (US)
ERNST RUSSELL (US)
International Classes:
C07F15/00; C07B61/00; C07D241/36
Foreign References:
US6031098A2000-02-29
US20020197638A12002-12-26
Other References:
JUNICKE, H. ET AL.: "A Rhodium(III) Complex for High-Affinity DNA Base-Pair Mismatch Recognition.", PROC. NATL. ACAD. SCI., vol. 100, 2003, pages 3737 - 3742, XP055132460
JACKSON, B. A. ET AL.: "Recognition of Base Mismatches in DNA by 5,6-Chrysenequinone Diimine Complexes of Rhodium(III): A Proposed Mechanism for Preferential Binding in Destabilized Regions of the Double Helix.", BIOCHEMISTRY, vol. 39, 2000, pages 6176 - 6182, XP055132463
Attorney, Agent or Firm:
BALLEW CHANG, Nicole (Parker & Hale LLP,P.O. Box 2900, Glendale CA, US)
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