Title:
METAP-2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND THERAPEUTIC METHODS THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/206350
Kind Code:
A1
Abstract:
Provided herein are inhibitors of methionine aminopeptidase 2 (MetAP-2) and pharmaceutical compositions thereof, and their use and methods of treatment, reduction or prevention of certain diseases or conditions associated with MetAP-2 (e.g., cancer, obesity, rheumatoid arthritis and psoriasis).
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Inventors:
LOU RONGLIANG (CN)
YU NINGHUI (CN)
YU NINGHUI (CN)
Application Number:
PCT/CN2022/080544
Publication Date:
October 06, 2022
Filing Date:
March 14, 2022
Export Citation:
Assignee:
CANWELL BIOTECH LTD (CN)
International Classes:
C07D207/22; A61K31/40; A61K31/4015; A61K31/402; A61K31/4025; A61P3/04; A61P3/10; A61P17/06; A61P19/02; A61P35/00; C07D401/04; C07D401/12; C07D405/04; C07D413/14
Domestic Patent References:
| WO2016020031A1 | 2016-02-11 | |||
| WO2012048775A1 | 2012-04-19 |
Foreign References:
| CN104245675A | 2014-12-24 |
Other References:
TIMO HEINRICH, JEYAPRAKASHNARAYANAN SEENISAMY, FRANK BECKER, BEATRIX BLUME, JöRG BOMKE, MELANIE DIETZ, UWE ECKERT, MANJA FRIE: ": A Clinical Compound for the Treatment of Cancer", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 62, no. 24, 26 December 2019 (2019-12-26), US , pages 11119 - 11134, XP055728008, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.9b01070
HEINRICH TIMO, SEENISAMY JEYAPRAKASHNARAYANAN, BLUME BEATRIX, BOMKE JÖRG, CALDERINI MICHEL, ECKERT UWE, FRIESE-HAMIM MANJA, KOHL R: "Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase-2 (MetAP-2) Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 62, no. 10, 23 May 2019 (2019-05-23), US , pages 5025 - 5039, XP055973560, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.9b00041
HEINRICH TIMO, SEENISAMY JEYAPRAKASHNARAYANAN, BLUME BEATRIX, BOMKE JÖRG, CALDERINI MICHEL, ECKERT UWE, FRIESE-HAMIM MANJA, KOHL R: "Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase-2 (MetAP-2) Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 62, no. 10, 23 May 2019 (2019-05-23), US , pages 5025 - 5039, XP055973560, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.9b00041
Attorney, Agent or Firm:
SHENZHEN ZHONGDING INTELLECTUAL PROPERTY AGENCY (CN)
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