Title:
METAXALONE COCRYSTALS
Document Type and Number:
WIPO Patent Application WO/2011/077252
Kind Code:
A3
Abstract:
The invention relates to improvements of the physiochemical and/or the pharmaceutical properties of metaxalone. Disclosed herein are several new cocrystals of metaxalone, including: a 1:1 metaxalore adipic acid cocrystal, a 1:0.5 metaxalore fumaric acid cocrystal, a 1:1 metaxalone salicyclic acid cocrystal, a 1:0.5 metaxalone succinic acid cocrystal, and a 1:0.5 metaxalone maleic acid cocrystal. The therapeutic uses of these metaxalone cocrystals are described as well as therapeutic compositions containing them.
Inventors:
HOLLAND JOANNE (GB)
FRAMPTON CHRISTOPHER (GB)
CHORLTON ALAN (GB)
GOODING DANIEL (GB)
FRAMPTON CHRISTOPHER (GB)
CHORLTON ALAN (GB)
GOODING DANIEL (GB)
Application Number:
PCT/IB2010/003460
Publication Date:
August 18, 2011
Filing Date:
December 22, 2010
Export Citation:
Assignee:
NUFORMIX LTD
HOLLAND JOANNE (GB)
FRAMPTON CHRISTOPHER (GB)
CHORLTON ALAN (GB)
GOODING DANIEL (GB)
HOLLAND JOANNE (GB)
FRAMPTON CHRISTOPHER (GB)
CHORLTON ALAN (GB)
GOODING DANIEL (GB)
International Classes:
C07D263/24; A61K31/421; A61P21/02
Domestic Patent References:
| WO2005055983A2 | 2005-06-23 | |||
| WO2004019937A1 | 2004-03-11 | |||
| WO2008045473A1 | 2008-04-17 |
Foreign References:
| US20070059356A1 | 2007-03-15 |
Other References:
SHAN N ET AL: "The role of cocrystals in pharmaceutical science", DRUG DISCOVERY TODAY, ELSEVIER, RAHWAY, NJ, US, vol. 13, no. 9-10, 1 May 2008 (2008-05-01), pages 440 - 446, XP022649919, ISSN: 1359-6446, [retrieved on 20080422], DOI: DOI:10.1016/J.DRUDIS.2008.03.004
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