Title:
METHANOL DERIVATIVES AS TRPV3 MODULATORS
Document Type and Number:
WIPO Patent Application WO/2013/062966
Kind Code:
A3
Abstract:
Disclosed herein are modulators of TRPV3 of formula (II): wherein G1, X1, X2, X3, X4, X5, G2, Ra, Rb, and u are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.
Inventors:
BAYBURT EROL K (US)
CLAPHAM BRUCE (US)
COX PHIL B (US)
DAANEN JEROME F (US)
GOMTSYAN ARTHUR (US)
KORT MICHAEL E (US)
KYM PHILIP R (US)
VOIGHT ERIC A (US)
SCHMIDT ROBERT G (US)
DART MICHAEL J (US)
GFESSER GREGORY (US)
CLAPHAM BRUCE (US)
COX PHIL B (US)
DAANEN JEROME F (US)
GOMTSYAN ARTHUR (US)
KORT MICHAEL E (US)
KYM PHILIP R (US)
VOIGHT ERIC A (US)
SCHMIDT ROBERT G (US)
DART MICHAEL J (US)
GFESSER GREGORY (US)
Application Number:
PCT/US2012/061478
Publication Date:
August 22, 2013
Filing Date:
October 23, 2012
Export Citation:
Assignee:
ABBVIE INC (US)
International Classes:
A61K31/337; C07D213/30; A61K31/341; A61K31/351; A61K31/352; A61K31/4402; A61K31/4433; A61K31/505; C07D239/26; C07D311/04; C07D401/06; C07D405/06; C07D405/08
Domestic Patent References:
| WO2012019315A1 | 2012-02-16 | |||
| WO2002022572A2 | 2002-03-21 | |||
| WO1995004042A1 | 1995-02-09 | |||
| WO2004043958A1 | 2004-05-27 |
Other References:
HARPER N J ET AL: "1-(3,4-Dichlorobenzamidomethyl)cyclohexyldimethylamine and related compounds as potential analgesics", JOURNAL OF MEDICINAL CHEMISTRY, vol. 17, no. 11, 1 January 1974 (1974-01-01), AMERICAN CHEMICAL SOCIETY, US, pages 1188 - 1193, XP002102296, ISSN: 0022-2623, DOI: 10.1021/JM00257A012
HATTERSLEY, P. J. ET AL: "Some reactions with 4-cyano-4-phenyltetrahydropyran", JOURNAL OF MEDICINAL CHEMISTRY., vol. 10, no. 1, 1967, US AMERICAN CHEMICAL SOCIETY. WASHINGTON., pages 128 - 129, XP002691850, ISSN: 0022-2623
COPPI, DONATO IVAN ET AL: "2-Lithiated-2-phenyloxetane: a new attractive synthon for the preparation of oxetane derivatives", CHEMICAL COMMUNICATIONS - CHEMCOM., vol. 47, no. 35, 21 September 2011 (2011-09-21), GBROYAL SOCIETY OF CHEMISTRY., pages 9918 - 9920, XP002691851, ISSN: 1359-7345
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 2003, ZHANG, YAO-MOU ET AL: "Cyclization reactions of 3,3-dimethyl-1-(1H-1,2,4-triazolo-1-yl)-2- butanone or substituted 1-(1H-1,2,4-triazolo-1-yl)acetophenone with dibromide compounds and its biological activities", XP002691852, retrieved from STN Database accession no. 2003:247751
HATTERSLEY, P. J. ET AL: "Some reactions with 4-cyano-4-phenyltetrahydropyran", JOURNAL OF MEDICINAL CHEMISTRY., vol. 10, no. 1, 1967, US AMERICAN CHEMICAL SOCIETY. WASHINGTON., pages 128 - 129, XP002691850, ISSN: 0022-2623
COPPI, DONATO IVAN ET AL: "2-Lithiated-2-phenyloxetane: a new attractive synthon for the preparation of oxetane derivatives", CHEMICAL COMMUNICATIONS - CHEMCOM., vol. 47, no. 35, 21 September 2011 (2011-09-21), GBROYAL SOCIETY OF CHEMISTRY., pages 9918 - 9920, XP002691851, ISSN: 1359-7345
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 2003, ZHANG, YAO-MOU ET AL: "Cyclization reactions of 3,3-dimethyl-1-(1H-1,2,4-triazolo-1-yl)-2- butanone or substituted 1-(1H-1,2,4-triazolo-1-yl)acetophenone with dibromide compounds and its biological activities", XP002691852, retrieved from STN Database accession no. 2003:247751
Attorney, Agent or Firm:
NENOW, Lydia et al. (Abbott Park, Illinois, US)
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