Title:
METHOD FOR ACHIEVING DESIRED GLIAL GROWTH FACTOR 2 PLASMA LEVELS
Document Type and Number:
WIPO Patent Application WO/2009/108390
Kind Code:
A3
Abstract:
The present invention relates to administering glial growth factor 2 (GGF2) to a patient in need thereof, to achieve serum levels of GGF2 within a desired therapeutic window determined based on the disease or disorder afflicting the patient. In a particular embodiment, the patient is suffering from a disease or disorder associated with reduced levels of myelination and the GGF2 is administered to promote myelination in the patient.
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Inventors:
KIM HAESUN (US)
CAGGIANO ANTHONY O (US)
CAGGIANO ANTHONY O (US)
Application Number:
PCT/US2009/001356
Publication Date:
November 18, 2010
Filing Date:
March 02, 2009
Export Citation:
Assignee:
ACORDA THERAPEUTICS INC (US)
KIM HAESUN (US)
CAGGIANO ANTHONY O (US)
KIM HAESUN (US)
CAGGIANO ANTHONY O (US)
International Classes:
A61K38/18; A61P25/02
Domestic Patent References:
| WO2004110359A2 | 2004-12-23 | |||
| WO1994004560A1 | 1994-03-03 |
Other References:
OGATA TORU ET AL: "Opposing extracellular signal-regulated kinase and Akt pathways control Schwann cell myelination", JOURNAL OF NEUROSCIENCE, vol. 24, no. 30, 28 July 2004 (2004-07-28), pages 6724 - 6732, 6703, XP002595402, ISSN: 0270-6474
MAUREL PATRICE ET AL: "Axonal regulation of Schwann cell proliferation and survival and the initial events of myelination requires PI 3-kinase activity", JOURNAL OF NEUROSCIENCE, vol. 20, no. 12, 15 June 2000 (2000-06-15), pages 4635 - 4645, XP002595403, ISSN: 0270-6474
SYED NEERAJA ET AL: "Soluble Neuregulin-1 Has Bifunctional, Concentration-Dependent Effects on Schwann Cell Myelination", JOURNAL OF NEUROSCIENCE, vol. 30, no. 17, April 2010 (2010-04-01), pages 6122 - 6131, XP009137128, ISSN: 0270-6474
MAUREL PATRICE ET AL: "Axonal regulation of Schwann cell proliferation and survival and the initial events of myelination requires PI 3-kinase activity", JOURNAL OF NEUROSCIENCE, vol. 20, no. 12, 15 June 2000 (2000-06-15), pages 4635 - 4645, XP002595403, ISSN: 0270-6474
SYED NEERAJA ET AL: "Soluble Neuregulin-1 Has Bifunctional, Concentration-Dependent Effects on Schwann Cell Myelination", JOURNAL OF NEUROSCIENCE, vol. 30, no. 17, April 2010 (2010-04-01), pages 6122 - 6131, XP009137128, ISSN: 0270-6474
Attorney, Agent or Firm:
Landrum, Charles, P. et al. (600 Congress Ave.Suite 240, Austin TX, US)
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