Title:
METHOD FOR ACQUIRING DATA FOR DISTINGUISHING PRESENCE OF CANCER CELLS AND/OR DISTINGUISHING ANTICANCER DRUG RESISTANCE, METHOD FOR ACQUIRING PREDICTION DATA, USE OF DISTINCTION MARKER IN SAME, AND DISTINGUISHING KIT
Document Type and Number:
WIPO Patent Application WO/2021/045202
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a method for acquiring data for distinguishing the presence of cancer cells and/or distinguishing anticancer drug resistance, a method for acquiring prediction data, a use of a distinction marker in said method, and a distinguishing kit, and in particular addresses the problem of distinguishing anticancer drug resistance before an anticancer drug is administered to a patient. Polysulfides, which are markers for anticancer drug resistance, are distinguished in cancerous tissue of a cancer patient prior to administration of an anticancer drug, thereby making it possible to distinguish anticancer drug resistance to the cancerous tissue of the cancer patient.
Inventors:
HISHIKI TAKAKO (JP)
SUEMATSU MAKOTO (JP)
SUEMATSU MAKOTO (JP)
Application Number:
PCT/JP2020/033640
Publication Date:
March 11, 2021
Filing Date:
September 04, 2020
Export Citation:
Assignee:
UNIV KEIO (JP)
International Classes:
A61P35/00; A61K31/7068; A61K33/243; C12N5/09; C12Q1/02; G01N21/65; G01N33/50
Domestic Patent References:
| WO2013072465A1 | 2013-05-23 |
Other References:
SHIOTA MEGUMI, NAYA MASAYUKI, YAMAMOTO TAKEHIRO, HISHIKI TAKAKO, TANI TAKEHARU, TAKAHASHI HIROYUKI, KUBO AKIKO, KOIKE DAISUKE, ITO: "Gold-nanofeve surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival", NATURE COMMUNICATIONS, vol. 9, 19 April 2018 (2018-04-19), pages 1561, XP055798825
SHIOTA, MEGUMI; TANI, TAKEHARU; YAMAZOE, SHOGO; HISHIKI, TAKAKO; HIRAOKA, NOBUYOSHI; SAYA, HIDEYUKI; KABE, YASUAKI; SUEMATSU, MAKO: "21p-234A-5 Analysis of cancer metabolism by surface enhanced Raman imaging", 79TH JSAP AUTUMN MEETING, 2018; NAGOYA, JAPAN; SEPTEMBER 18-21, 2018, vol. 79, 5 September 2018 (2018-09-05) - 21 September 2018 (2018-09-21), JP, pages 03, XP009534801
CHEN BAISHEN, SHEN ZHUOJIAN, WU DUOGUANG, XIE XUAN, XU XIA, LV LIANGZHAN, DAI HONGLUE, CHEN JU, GAN XIANGFENG: "Glutathione Peroxidase 1 Promotes NSCLC Resistance to Cisplatin via ROS-Induced Activation of PI3K/AKT Pathway", BIOMED RESEARCH INTERNATIONAL, vol. 2019, no. 7640547, 27 March 2019 (2019-03-27), pages 1 - 12, XP055798828
OSAMU NAGANO, HIDEYUKI SAYA: "Oxydation stress evasion mechanism in cancer stem cells", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 247, no. 9, 30 November 2013 (2013-11-30), JP , pages 983 - 988, XP009534830, ISSN: 0039-2359
KUNIKATA HIROSHI, IDA TOMOAKI, SATO KOTA, AIZAWA NAOKO, SAWA TOMOHIRO, TAWARAYAMA HIROSHI, MURAYAMA NAMIE, FUJII SHIGEMOTO, AKAIKE: "Metabolomic profiling of reactive persulfides and polysulfides in the aqueous and vitreous humors,", SCIENTIFIC REPORTS, vol. 7, no. 1, 7 February 2017 (2017-02-07), pages 41984, XP055586796
CAO XU, NIE XIAOWEI, XIONG SIPING, CAO LEI, WU ZHIYUAN, MOORE PHILIP K., BIAN JIN-SONG: "Renal protective effect of polysulfide in cisplatin-induced nephrotoxicity", REDOX BIOLOGY, vol. 15, 2 February 2018 (2018-02-02), pages 513 - 521, XP055798831
CAO XU, ZHANG WENCAN, MOORE PHILIP, BIAN JINSONG: "Protective Smell of Hydrogen Sulfide and Polysulfide in Cisplatin-Induced Nephrotoxicity", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 20, no. 2, 14 January 2019 (2019-01-14), pages 313, XP055798833
SUEMATSU MAKOTO: "Surface enhanced Raman spectroscopy imaging : Elucidation of redox mentabolism by unlabeled and unstained tumor tissue analysis", PROGRAMS AND ABSTRACTS OF COLLABORATIVE ACADEMIC CONFERENCE OF THE 18TH NITRIC OXIDE SOCIETY OF JAPAN AND THE 71ST MEETING SOCIETY FOR FREE RADICAL RESEARCH JAPAN; MAY 17-18, 2018, 19 April 2018 (2018-04-19) - 18 May 2018 (2018-05-18), JP, pages 44, XP009534963
MAKOTO SUEMATSU, MASAYUKI NAYA, MEMI SHIODA, SHOGO YAMAZOE, AKIKO KUBO, TAKAKO HISHIKI, MAYUMI KAJIMURA, YASUAKI KABE: "Raman imaging for fingerprinting intermolecular vibration in metabolic systems under disease conditions", EXPERIMENTAL MEDICINE, vol. 36, no. 5 (Special edition), 15 March 2018 (2018-03-15), JP , pages 37 (669) - 45 (677), XP009534831, ISSN: 0288-5514
SUEMATSU, MAKOTO: "Metabolism analysis of cancer by imaging metabolomics", CANCER AND METABOLISM STUDY GROUP PROGRAM & ABSTRACTS; 7TH CANCER AND METABOLISM STUDY GROUP; AUGUST 1-2, 2019, vol. 7, 30 June 2019 (2019-06-30) - 2 August 2019 (2019-08-02), JP, pages 38, XP009534964
A. KUBO, M. OHMURA, T. NAKANISHI, T. HISHIKI, T. YAMAMOTO, M. SUEMATSU: "Detection of accumulated glutathione hydropersulfide on human colon cancer-bearing livers of superimmunodeficient NOG mice by MALDI MS imaging", LECTURE ABSTRACTS OF ANNUAL CONFERENCE ON MASS SPECTROMETRY, vol. 63, 8 June 2015 (2015-06-08) - 19 June 2015 (2015-06-19), JP, pages 169, XP009534965
NATURE COMMUNICATIONS, vol. 9, no. 1561, 2018
ANALYT CHEM, vol. 78, 2006, pages 2631 - 2639
INORG. CHEM., vol. 15, 1976, pages 1759 - 1763
PHYS CHEM INORB PHYS., vol. 17, 2015, pages 5155 - 5171
See also references of EP 4026588A4
SHIOTA, MEGUMI; TANI, TAKEHARU; YAMAZOE, SHOGO; HISHIKI, TAKAKO; HIRAOKA, NOBUYOSHI; SAYA, HIDEYUKI; KABE, YASUAKI; SUEMATSU, MAKO: "21p-234A-5 Analysis of cancer metabolism by surface enhanced Raman imaging", 79TH JSAP AUTUMN MEETING, 2018; NAGOYA, JAPAN; SEPTEMBER 18-21, 2018, vol. 79, 5 September 2018 (2018-09-05) - 21 September 2018 (2018-09-21), JP, pages 03, XP009534801
CHEN BAISHEN, SHEN ZHUOJIAN, WU DUOGUANG, XIE XUAN, XU XIA, LV LIANGZHAN, DAI HONGLUE, CHEN JU, GAN XIANGFENG: "Glutathione Peroxidase 1 Promotes NSCLC Resistance to Cisplatin via ROS-Induced Activation of PI3K/AKT Pathway", BIOMED RESEARCH INTERNATIONAL, vol. 2019, no. 7640547, 27 March 2019 (2019-03-27), pages 1 - 12, XP055798828
OSAMU NAGANO, HIDEYUKI SAYA: "Oxydation stress evasion mechanism in cancer stem cells", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 247, no. 9, 30 November 2013 (2013-11-30), JP , pages 983 - 988, XP009534830, ISSN: 0039-2359
KUNIKATA HIROSHI, IDA TOMOAKI, SATO KOTA, AIZAWA NAOKO, SAWA TOMOHIRO, TAWARAYAMA HIROSHI, MURAYAMA NAMIE, FUJII SHIGEMOTO, AKAIKE: "Metabolomic profiling of reactive persulfides and polysulfides in the aqueous and vitreous humors,", SCIENTIFIC REPORTS, vol. 7, no. 1, 7 February 2017 (2017-02-07), pages 41984, XP055586796
CAO XU, NIE XIAOWEI, XIONG SIPING, CAO LEI, WU ZHIYUAN, MOORE PHILIP K., BIAN JIN-SONG: "Renal protective effect of polysulfide in cisplatin-induced nephrotoxicity", REDOX BIOLOGY, vol. 15, 2 February 2018 (2018-02-02), pages 513 - 521, XP055798831
CAO XU, ZHANG WENCAN, MOORE PHILIP, BIAN JINSONG: "Protective Smell of Hydrogen Sulfide and Polysulfide in Cisplatin-Induced Nephrotoxicity", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 20, no. 2, 14 January 2019 (2019-01-14), pages 313, XP055798833
SUEMATSU MAKOTO: "Surface enhanced Raman spectroscopy imaging : Elucidation of redox mentabolism by unlabeled and unstained tumor tissue analysis", PROGRAMS AND ABSTRACTS OF COLLABORATIVE ACADEMIC CONFERENCE OF THE 18TH NITRIC OXIDE SOCIETY OF JAPAN AND THE 71ST MEETING SOCIETY FOR FREE RADICAL RESEARCH JAPAN; MAY 17-18, 2018, 19 April 2018 (2018-04-19) - 18 May 2018 (2018-05-18), JP, pages 44, XP009534963
MAKOTO SUEMATSU, MASAYUKI NAYA, MEMI SHIODA, SHOGO YAMAZOE, AKIKO KUBO, TAKAKO HISHIKI, MAYUMI KAJIMURA, YASUAKI KABE: "Raman imaging for fingerprinting intermolecular vibration in metabolic systems under disease conditions", EXPERIMENTAL MEDICINE, vol. 36, no. 5 (Special edition), 15 March 2018 (2018-03-15), JP , pages 37 (669) - 45 (677), XP009534831, ISSN: 0288-5514
SUEMATSU, MAKOTO: "Metabolism analysis of cancer by imaging metabolomics", CANCER AND METABOLISM STUDY GROUP PROGRAM & ABSTRACTS; 7TH CANCER AND METABOLISM STUDY GROUP; AUGUST 1-2, 2019, vol. 7, 30 June 2019 (2019-06-30) - 2 August 2019 (2019-08-02), JP, pages 38, XP009534964
A. KUBO, M. OHMURA, T. NAKANISHI, T. HISHIKI, T. YAMAMOTO, M. SUEMATSU: "Detection of accumulated glutathione hydropersulfide on human colon cancer-bearing livers of superimmunodeficient NOG mice by MALDI MS imaging", LECTURE ABSTRACTS OF ANNUAL CONFERENCE ON MASS SPECTROMETRY, vol. 63, 8 June 2015 (2015-06-08) - 19 June 2015 (2015-06-19), JP, pages 169, XP009534965
NATURE COMMUNICATIONS, vol. 9, no. 1561, 2018
ANALYT CHEM, vol. 78, 2006, pages 2631 - 2639
INORG. CHEM., vol. 15, 1976, pages 1759 - 1763
PHYS CHEM INORB PHYS., vol. 17, 2015, pages 5155 - 5171
See also references of EP 4026588A4
Attorney, Agent or Firm:
IP FIRM SHUWA (JP)
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