Title:
METHOD FOR ADMINISTERING HYPNOTIC/SEDATIVE AGENT
Document Type and Number:
WIPO Patent Application WO/2014/034890
Kind Code:
A1
Abstract:
A hypnotic/sedative agent comprising methyl 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2- a][1,4]benzodiazepin-4-yl]propanoate or a salt thereof is administered to a vein of a patient by a two-step administration method as disclosed in the present invention, whereby general anesthesia can be introduced safely and rapidly and the state of general anesthesia can be maintained.
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Inventors:
KONDO MAKI (JP)
KONOMI TOSHIHIKO (JP)
SATO SHIGEHITO (JP)
DOI MATSUYUKI (JP)
KONOMI TOSHIHIKO (JP)
SATO SHIGEHITO (JP)
DOI MATSUYUKI (JP)
Application Number:
PCT/JP2013/073414
Publication Date:
March 06, 2014
Filing Date:
August 30, 2013
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
NAT UNIV CORP HAMAMATSU (JP)
NAT UNIV CORP HAMAMATSU (JP)
International Classes:
A61K31/5517; A61K31/4468; A61K31/567; A61K45/00; A61P25/20
Domestic Patent References:
| WO2012062439A1 | 2012-05-18 | |||
| WO2000069836A1 | 2000-11-23 | |||
| WO2008007071A1 | 2008-01-17 | |||
| WO2012062439A1 | 2012-05-18 | |||
| WO2008007081A1 | 2008-01-17 | |||
| WO2011032692A1 | 2011-03-24 |
Foreign References:
| JP2002544266A | 2002-12-24 | |||
| JP2009542785A | 2009-12-03 |
Other References:
ANTONIK, LJ. ET AL.: "A placebo- and Midazolam- controlled phase I single ascending-dose study evaluating the safety, pharmacokinetics, and pharmacodynamics of Remimazolam(CNS 7056):Part I. Safety, efficacy, and basic pharmacokinetics", ANESTHESIA & ANALGESIA, vol. 115, no. 2, August 2012 (2012-08-01), pages 274 - 283, XP055234764
UPTON, RN. ET AL.: "A dose escalation study in sheep of the effects of the benzodiazepine CNS 7056 on sedation, the EEG and the respiratory and cardiovascular systems", BRITISH JOURNAL OF PHARMACOLOGY, vol. 155, 2008, pages 52 - 61, XP055039848
UPTON, RN. ET AL.: "Pharmacokinetics and pharmacodynamics of the short-acting sedative CNS 7056 in sheep", BRITISH JOURNAL OF ANAESTHESIA, vol. 105, no. 6, 2010, pages 798 - 809, XP009154068
WILTSHIRE, HR. ET AL.: "A placebo- and Midazolam-controlled phase I single ascending- dose study evaluating the safety, pharmacokinetics, and pharmacodynamics of Remimazolam(CNS 7056):Part II. Population Pharmacokinetic and Pharmacodynamic Modeling and Simulation", ANESTHESIA & ANALGESIA, vol. 115, no. 2, August 2012 (2012-08-01), pages 284 - 296, XP055234768
ANESTHESIA AND ANALGESIA, vol. 115, 2012, pages 274 - 283
ANESTHESIA AND ANALGESIA, vol. 115, 2012, pages 284 - 296
BRITISH JOURNAL OF PHARMACOLOGY, vol. 155, 2008, pages 52 - 61
BRITISH JOURNAL OF ANAESTHESIA, vol. 105, no. 6, 2010, pages 798 - 809
RICHARD C. LAROCK: "Comprehensive Organic Transformations: A Guide to Functional Group Preparations", 1999, JOHN WILEY & SONS, INC.
"Japanese pharmaceutical excipients", 2000, YAKUJI NIPPO LIMITED
"Notification Nos. 606 and 607 of the Pharmaceutical Affairs Bureau", 25 April 1997, MINISTRY OF HEALTH AND WELFARE
See also references of EP 2891494A4
UPTON, RN. ET AL.: "A dose escalation study in sheep of the effects of the benzodiazepine CNS 7056 on sedation, the EEG and the respiratory and cardiovascular systems", BRITISH JOURNAL OF PHARMACOLOGY, vol. 155, 2008, pages 52 - 61, XP055039848
UPTON, RN. ET AL.: "Pharmacokinetics and pharmacodynamics of the short-acting sedative CNS 7056 in sheep", BRITISH JOURNAL OF ANAESTHESIA, vol. 105, no. 6, 2010, pages 798 - 809, XP009154068
WILTSHIRE, HR. ET AL.: "A placebo- and Midazolam-controlled phase I single ascending- dose study evaluating the safety, pharmacokinetics, and pharmacodynamics of Remimazolam(CNS 7056):Part II. Population Pharmacokinetic and Pharmacodynamic Modeling and Simulation", ANESTHESIA & ANALGESIA, vol. 115, no. 2, August 2012 (2012-08-01), pages 284 - 296, XP055234768
ANESTHESIA AND ANALGESIA, vol. 115, 2012, pages 274 - 283
ANESTHESIA AND ANALGESIA, vol. 115, 2012, pages 284 - 296
BRITISH JOURNAL OF PHARMACOLOGY, vol. 155, 2008, pages 52 - 61
BRITISH JOURNAL OF ANAESTHESIA, vol. 105, no. 6, 2010, pages 798 - 809
RICHARD C. LAROCK: "Comprehensive Organic Transformations: A Guide to Functional Group Preparations", 1999, JOHN WILEY & SONS, INC.
"Japanese pharmaceutical excipients", 2000, YAKUJI NIPPO LIMITED
"Notification Nos. 606 and 607 of the Pharmaceutical Affairs Bureau", 25 April 1997, MINISTRY OF HEALTH AND WELFARE
See also references of EP 2891494A4
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
Aoki 篤 (JP)
Aoki 篤 (JP)
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