Title:
A METHOD OF ADMINISTERING A NANOPARTICLE
Document Type and Number:
WIPO Patent Application WO/2021/193393
Kind Code:
A1
Abstract:
The present invention provides a method of administering a nanoparticle. The disclosure also relates to a method of labeling or targeting the surface of endothelial cells in the brain. The present invention provides a method of targeting or delivering a nanoparticle into a brain parenchyma through blood-brain barrier (BBB) with minimal targeting to other peripheral organs.
Inventors:
GONZALEZ CARTER DANIEL (JP)
KATAOKA KAZUNORI (JP)
KATAOKA KAZUNORI (JP)
Application Number:
PCT/JP2021/011290
Publication Date:
September 30, 2021
Filing Date:
March 19, 2021
Export Citation:
Assignee:
KAWASAKI INST OF INDUSTRIAL PROMOTION (JP)
International Classes:
A61K47/68; A61K47/69
Domestic Patent References:
| WO2017002979A1 | 2017-01-05 |
Foreign References:
| US20180185281A1 | 2018-07-05 |
Other References:
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WIEWRODT RAINER ET AL: "Size-dependent intracellular immunotargeting of therapeutic cargoes into endothelial cells", BLOOD, vol. 99, no. 3, 1 February 2002 (2002-02-01), US, pages 912 - 922, XP055811707, ISSN: 0006-4971, DOI: 10.1182/blood.V99.3.912
XIAOBIN ZHANG ET AL: "Creation and evaluation of a single-chain antibody tetramer that targets brain endothelial cells", AICHE JOURNAL, vol. 60, no. 4, 13 April 2014 (2014-04-13), US, pages 1245 - 1252, XP055363874, ISSN: 0001-1541, DOI: 10.1002/aic.14348
DAN MO ET AL: "Binding, Transcytosis and Biodistribution of Anti-PECAM-1 Iron Oxide Nanoparticles for Brain-Targeted Delivery", PLOS ONE, vol. 8, no. 11, 20 November 2013 (2013-11-20), pages e81051, XP055811109, DOI: 10.1371/journal.pone.0081051
ANDREW J. CLARK ET AL: "Increased brain uptake of targeted nanoparticles by adding an acid-cleavable linkage between transferrin and the nanoparticle core", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 112, no. 40, 21 September 2015 (2015-09-21), pages 12486 - 12491, XP055340526, ISSN: 0027-8424, DOI: 10.1073/pnas.1517048112
JOHNSEN KASPER BENDIX ET AL: "Targeting transferrin receptors at the blood-brain barrier improves the uptake of immunoliposomes and subsequent cargo transport into the brain parenchyma", SCIENTIFIC REPORTS, vol. 7, no. 1, 4 September 2017 (2017-09-04), XP055810911, Retrieved from the Internet
PAGANELLI G ET AL: "ANTIBODY-GUIDED THREE-STEP THERAPY FOR HIGH GRADE GLIOMA WITH YTTRIUM-90 BIOTIN", EUROPEAN JOURNAL OF NUCLEAR MEDICINE, SPRINGER, BERLIN, HEIDELBERG, DE, vol. 26, no. 4, 1 April 1999 (1999-04-01), pages 348 - 357, XP008019281, ISSN: 0340-6997, DOI: 10.1007/S002590050397
GONZALEZ-CARTER DANIEL ET AL: "Targeting nanoparticles to the brain by exploiting the blood-brain barrier impermeability to selectively label the brain endothelium", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 117, no. 32, 23 July 2020 (2020-07-23), pages 19141 - 19150, XP055810914, ISSN: 0027-8424, Retrieved from the Internet
ABBOTT JPATABENDIGE ADOLMAN DYUSOF SBEGLEY D: "Structure and function of the blood-brain barrier", NEUROBIOL DIS, vol. 37, no. 1, 2010, pages 13 - 25, XP026765781, DOI: 10.1016/j.nbd.2009.07.030
ALTANNAVCH TROUBALOVA KKUCERA PANDEL M: "Effect of high glucose concentrations on expression of ELAM-1, VCAM-1 and ICAM-1 in HUVEC with and without cytokine activation", PHYSIOL RES, vol. 53, no. 1, 2004, pages 77 - 82
ANDREONE BCHOW BTATA ALACOSTE BBEN-ZVI ABULLOCK KDEIK AGINTY DCLISH CGU C: "Blood-brain barrier permeability is regulated by lipid transport-dependent suppression of caveolae-mediated transcytosis", NEURON, vol. 94, no. 3, 2017, pages 581 - 594, XP029998488, DOI: 10.1016/j.neuron.2017.03.043
ANRAKU YKUWAHARA HFUKUSATO YMIZOGUCHI AISHII TNITTA KMATSUMOTO YTOH KMIYATA KUCHIDA S: "Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain", NAT COMMUN, vol. 8, no. 1, 2017, pages 1001, XP055533568, DOI: 10.1038/s41467-017-00952-3
AZCUTIA VABU-TAHA MROMACHO TVAZQUEZ-BELLA MMATESANZ NLUSCINSKAS FRODRIGUEZ-MANAS LSANZ MSANCHEZ-FERRER CPEIRO C: "Inflammation determines the pro-adhesive properties of high extracellular d-glucose in human endothelial cells in vitro and rat microvessel in vivo", PLOS ONE, vol. 5, no. 4, 2010, pages el0091
BAKHSHI FMAO MSHAJAHAN APIEGELER TCHEN ZCHERNAYA OSHARMA TELLIOTT WSZULCEK RBOGAARD H: "Nitrosation-dependent caveolin 1 phosphorylation, ubiqui-tination, and degradation and its association with idiopathic pulmonary arterial hypertension", PULM CIRC, vol. 3, no. 4, 2013, pages 816 - 830
BEN-ZVI ALACOSTE BKUR EANDREONE BMAYSHAR YYAN HGU C: "Mfsd2a is critical for the formation and function of the blood-brain barrier", NATURE, vol. 509, 2014, pages 507 - 511, XP055329327, DOI: 10.1038/nature13324
BREWER CRIEHM J: "Evidence for possible nonspecific reactions between N-ethylmaleimide and proteins", ANALYTICAL BIOCHEM, vol. 18, no. 2, 1967, pages 248 - 255, XP024824739, DOI: 10.1016/0003-2697(67)90007-3
CHEN YCHANG MDAVIDSON B: "Molecular signatures of disease brain endothelia provide new sites for CNS-directed enzyme therapy", NAT MED, vol. 15, no. 10, 2009, pages 1215 - 1218, XP002633635, DOI: 10.1038/nm.2025
CLARK ADAVIS M: "Increased brain uptake of targeted nanoparticles by adding an acid-cleavable linkage between transferrin and the nanoparticle core", PNAS, vol. 112, no. 40, 2015, pages 12486 - 12491, XP055340526, DOI: 10.1073/pnas.1517048112
DAN MCOCHRAN DYOKEL RDZIUBLA T: "Binding, transcytosis and biodistribution of anti-PECAM-1 iron oxide nanoparticles for brain-targeted delivery", PLOS ONE, vol. 8, no. 11, 2013, pages e81051
DEANE RDU YAN SSUBMAMARYAN RLARUE BJOVANOVIC SHOGG EWELCH DMANNESS LLIN CYU J: "RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain", NAT MED, vol. 9, no. 7, 2003, pages 907 - 913, XP002460976, DOI: 10.1038/nm890
EPPIHIMER MRUSSEL JLANGLEY RVALLIEN GANDERSON DGRANGER N: "Differential expression of platelet-endothelial cell adhesion molecule-1 in murine tissues", MICROCIRCULATION, vol. 5, no. 2-3, 1998, pages 179 - 188
FARRELL CYANG JPARDRIDGE W: "Glut-1 glucose transporter is present within apical and basolateral membranes of brain epithelial interfaces and in microvascular enothelia with and without tight junctions", J HISTOCHEM CYTOCHEM, vol. 40, no. 2, 1992, pages 193 - 199
FRAGA SPINHO MSOARES-DA-SILVA P: "Expression of LAT-1 and LAT-2 amino acid transporters in human and rat intestinal epithelial cells", AMINO ACIDS, vol. 29, no. 3, 2005, pages 229 - 233
GOLDBERGER AMIDDLETON KOLIVER JPADDOCK CYAN HDELISSER HALBELDA SNEWMAN P: "Biosynthesis and processing of the cell adhesion molecule PECAM-1 includes production of a soluble form", J BIOL CHEM, vol. 269, no. 25, 1994, pages 17183 - 91, XP002103130
GONZALEZ-CARTER DONG ZMCGILVERY CDUNLOP IDEXTER DPORTER A: "L-DOPA functionalized, multi-branched gold nanoparticles as brain-targeted nano-vehicles", NANOMEDICINE, vol. 15, no. 1, 2019, pages 1 - 11, XP085558007, DOI: 10.1016/j.nano.2018.08.011
GOULATIS LSHUSTA E: "Protein engineering approaches for regulating blood-brain barrier transcytosis", CURR OPIN STRUCT BIOL, vol. 45, 2017, pages 100 - 115
HAWKINS BDAVIS T: "The blood-brain barrier/neurovascular unit in health and disease", PHARMACOL REV, vol. 57, no. 2, 2005, pages 173 - 185, XP002563573, DOI: 10.1124/pr.57.2.4
JOHNSEN KBURKHART AMELANDER FKEMPEN PVEJLEBO JSIUPKA PNIELSEN MANDRESEN TMOOS T: "Targeting transferrin receptors at the blood-brain barrier improves the uptake of immunoliposomes and subsequent cargo transport into the brain parenchyma", SCI REP, vol. 7, no. 1, 2017, pages 10396
KIM JWESSLING-RESNICK M: "The role of iron metabolism in lung inflammation and injury", J ALLERGY THER, vol. 3, no. 4, 2012, pages 004
KRONSTEIN RSEEBACH JGROSSKLAUS SMINTEN CENGELARDT BDRAB MLIEBNER SAR-SENIJEVIC YTAHA AAFANASIEVA T: "Caveolin-1 opens endothelial cell juncctions by targeting catenins", CARDIOVASC RES, vol. 93, no. 1, 2012, pages 130 - 140
KUWAHARA HNISHINA KYOSHIDA KNISHINA TYAMAMOTO MSAITO YPIAO WYOSHIDA MMIZUSAWA HYOKOTA T: "Efficient in vivo delivery of siRNA into brain capillary endothelial cells along with endogenous lipoprotein", MOL THER, vol. 19, no. 12, 2011, pages 2213 - 2221, XP055076178, DOI: 10.1038/mt.2011.186
LAM FMORTON SWYCKOFF JHAN THWANG MMAFFA ABALKANSKA-SINCLAIR EYAFFE MFLOYD SHAMMOND P: "Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles", NAT COMM, vol. 9, 2018, pages 1991
LI JZHOU LYE DHUANG SSHAO KHUANG RHAN LLIU YLIU SYE L: "Choline-derivate-modified nanoparticles for brain-targeting gene delivery", ADV MATER, vol. 23, no. 39, 2011, pages 4561 - 4520
LI JGUO YKUANG YAN SMA HJIANG C: "Cholinie transporter-targeting and co-delivery system for glioma therapy", BIOMATERIALS, vol. 34, no. 36, 2013, pages 9142 - 9148, XP028714770, DOI: 10.1016/j.biomaterials.2013.08.030
LI LDI XZHANG SKAN QLIU HLU TWANG YFU QSUN JHE Z: "Large amino acid transporter 1 mediated glutamate modified docetaxel-loaded liposomes for glioma targeting", COLLOID SURF B, vol. 141, 2016, pages 260 - 267
LIN SRACZ JTAI MBROOKS KRZECZYCKI PHEATH LNEWSTEAD MSTANDIFORD TROSANIA GSTRINGER K: "A role for low density lipoprotein receptor-related protein 1 in the cellular uptake of tissue plasminogen activator in the lungs", PHARM RES, vol. 33, no. 1, 2016, pages 72 - 82, XP035927606, DOI: 10.1007/s11095-015-1763-6
LIU AAGUET FDANUSER GSCHMID S: "Local clustering of transferrin receptors promotes clathrin-coated pit initiation", J CELL BIOL, vol. 1919, no. 7, 2010, pages 1381 - 1393
LUTTON EFARNEY SANDREWS ASHUVAEV VCHUANG GMUZYKANTOV VRAMIREZ S: "Endothelial targeted strategies to combat oxidative stress: improving outcomes in traumatic brain injury", FRONT NEUROL, vol. 6, no. 10, 2019, pages 582
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