Title:
METHOD FOR ALDOL REACTION IN WATER
Document Type and Number:
WIPO Patent Application WO/2002/074724
Kind Code:
A1
Abstract:
A method for an aldol reaction in water, characterized in that an aldehyde and an silyl enol ether is reacted in water as a medium in the presence of a boronic acid represented by the general formula (1): R?1¿R?2¿BOH (1) wherein R?1¿ and R?2¿ are hydrocarbon groups which may be the same or different and may have a substituent, a surfactant and a Brfnsted acid. The method for an aldol reaction in water allows the production of a product with high selectivity in high yield by the use of a boron source in an catalytic amount.
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Inventors:
KOBAYASHI SHU (JP)
MANABE KEI (JP)
MANABE KEI (JP)
Application Number:
PCT/JP2002/002185
Publication Date:
September 26, 2002
Filing Date:
March 08, 2002
Export Citation:
Assignee:
JAPAN SCIENCE & TECH CORP (JP)
KOBAYASHI SHU (JP)
MANABE KEI (JP)
KOBAYASHI SHU (JP)
MANABE KEI (JP)
International Classes:
C07B61/00; C07C45/51; C07C45/70; C07C45/72; C07C49/83; C07C45/74; C07C327/22; (IPC1-7): C07C45/70; C07C45/72; C07C49/83; C07B61/00
Domestic Patent References:
| WO2000007719A1 | 2000-02-17 |
Foreign References:
| JPH1112216A | 1999-01-19 | |||
| JPH11244705A | 1999-09-14 | |||
| JPH0725808A | 1995-01-27 | |||
| JPH1053075A | 1998-02-24 |
Other References:
MORI Y. ET AL.: "Catalytic use of a boron source for boron enolate mediated stereoselective aldol reactions in water", ANGEW. CHEM. INT. ED., vol. 40, no. 15, 2001, pages 2816 - 2818, XP002952247
ISHIHARA K. ET AL.: "Diarylborinic acids as efficient catalysts for selective dehydration of aldols", SYNLETT, no. 15, May 1997 (1997-05-01), pages 597 - 599, XP002952246
TETRAHEDRON LETTERS, vol. 40, 1999, pages 3773 - 3776
TETRAHEDRON LETT., vol. 39, 1998, pages 5389 - 5392
J. AM. CHEM. SOC., vol. 120, 1998, pages 9517 - 9525
SYNLETT, 1999, pages 547 - 548
AM. CHEM. SOC., vol. 122, 2000, pages 7202 - 7207
CHEM. LETT., 1981, pages 153 - 156
CHEM. LETT., 1982, pages 241 - 244
See also references of EP 1375464A4
ISHIHARA K. ET AL.: "Diarylborinic acids as efficient catalysts for selective dehydration of aldols", SYNLETT, no. 15, May 1997 (1997-05-01), pages 597 - 599, XP002952246
TETRAHEDRON LETTERS, vol. 40, 1999, pages 3773 - 3776
TETRAHEDRON LETT., vol. 39, 1998, pages 5389 - 5392
J. AM. CHEM. SOC., vol. 120, 1998, pages 9517 - 9525
SYNLETT, 1999, pages 547 - 548
AM. CHEM. SOC., vol. 122, 2000, pages 7202 - 7207
CHEM. LETT., 1981, pages 153 - 156
CHEM. LETT., 1982, pages 241 - 244
See also references of EP 1375464A4
Attorney, Agent or Firm:
Nishizawa, Toshio (Udagawa-cho Shibuya-ku, Tokyo, JP)
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