Title:
METHOD FOR ALPHA METALATION OF A DERIVATIVE WHICH IS HETEROCYCLIC, MONOCYCLIC OR POLYCYCLIC AND POSSESSES AT LEAST ONE 5-ATOM HETEROCYCLE AND IS UNSATURATED OR AROMATIC
Document Type and Number:
WIPO Patent Application WO2000064905
Kind Code:
A3
Abstract:
The invention relates to a method for alpha metalation of a derivative which is heterocyclic, monocyclic or polycyclic and possesses at least one 5-atom heterocycle and is unsaturated or aromatic or substituted. The invention is characterized in that said derivative is reacted with an efficacious amount of at least one alkaline metal in the presence of a compound of formula (I): RCI, wherein R represents a hydrocarbon radical having 1-20 carbon atoms and which can be a saturated or unsaturated, linear or branched acyclic aliphatic radical; a saturated, unsaturated, monocyclic or polycyclic cycloaliphatic radical; a saturated or unsaturated, linear or branched aliphatic radical carrying at cyclic substituent.
Inventors:
WAGNER ALAIN (FR)
MIOSKOWSKI CHARLES (FR)
GISSOT ARNAUD (FR)
DESMURS JEAN-ROGER (FR)
JOST SYLVIE (FR)
MIOSKOWSKI CHARLES (FR)
GISSOT ARNAUD (FR)
DESMURS JEAN-ROGER (FR)
JOST SYLVIE (FR)
Application Number:
PCT/FR2000/001072
Publication Date:
March 15, 2001
Filing Date:
April 21, 2000
Export Citation:
Assignee:
RHODIA CHIMIE SA (FR)
WAGNER ALAIN (FR)
MIOSKOWSKI CHARLES (FR)
GISSOT ARNAUD (FR)
DESMURS JEAN ROGER (FR)
JOST SYLVIE (FR)
WAGNER ALAIN (FR)
MIOSKOWSKI CHARLES (FR)
GISSOT ARNAUD (FR)
DESMURS JEAN ROGER (FR)
JOST SYLVIE (FR)
International Classes:
C07D307/85; C07D333/22; C07D333/40; C07F1/04; (IPC1-7): C07F1/06; C07D307/85; C07D333/22; C07D333/40
Foreign References:
| US3932545A | 1976-01-13 |
Other References:
BENOIT, PATRICE; COLLIGNON, NOEL: "Métallations par les n-butyl-cesium et -potassium en séries du thiophène et du furanne", BULL. SOC. CHIM. FR., vol. 5-6, no. 2, 1975, pages 1302 - 1306, XP002150353
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