Title:
METHOD FOR THE ANALYSIS, IDENTIFICATION AND QUANTIFICATION OF FURFURALS AS FOOD QUALITY MARKERS
Document Type and Number:
WIPO Patent Application WO/2010/013225
Kind Code:
A1
Abstract:
The present invention relates to a method of analysis, identification and quantification of furfurals in food. The present invention describes the chromatographic separation of compounds using direct immersion solid phase microextraction (DI-SPME) and high resolution gas chromatography coupled to mass spectrometry (GC-MS), allowing the simultaneous identification and quantification of furfurals, which are markers for food quality. Examples are included of the use of this method in analysing various food stuffs and matrices, further applications may include monitoring food or nutritional supplements, human or animal health, other biological activities and in diagnosing disease.
Inventors:
MENDES SARDAO MONTEIRO GASPAR (PT)
Application Number:
PCT/IB2009/053366
Publication Date:
February 04, 2010
Filing Date:
August 03, 2009
Export Citation:
Assignee:
UNIV NOVA DE LISBOA (PT)
MENDES SARDAO MONTEIRO GASPAR (PT)
MENDES SARDAO MONTEIRO GASPAR (PT)
International Classes:
G01N30/06
Other References:
GASPAR E M S M ET AL: "Simple gas chromatographic method for furfural analysis", JOURNAL OF CHROMATOGRAPHY, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 1216, no. 14, 3 April 2009 (2009-04-03), pages 2762 - 2767, XP025970903, ISSN: 0021-9673, [retrieved on 20081017]
BERANEK J ET AL: "Evaluation of solid-phase microextraction methods for determination of trace concentration aldehydes in aqueous solution", JOURNAL OF CHROMATOGRAPHY, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 1209, no. 1-2, 31 October 2008 (2008-10-31), pages 44 - 54, XP025546000, ISSN: 0021-9673, [retrieved on 20080910]
FITZGERALD G ET AL: "Characterisation of whiskeys using solid-phase microextraction with gas chromatography-mass spectrometry", JOURNAL OF CHROMATOGRAPHY, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 896, no. 1-2, 27 October 2000 (2000-10-27), pages 351 - 359, XP004218798, ISSN: 0021-9673
KATAOKA H ET AL: "Applications of solid-phase microextraction in food analysis", JOURNAL OF CHROMATOGRAPHY, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 880, no. 1-2, 1 June 2000 (2000-06-01), pages 35 - 62, XP004204839, ISSN: 0021-9673
YANG X. AND T. PEPPARD: "Solid-Phase Microextraction for Flavor Analysis", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 42, no. 9, September 1994 (1994-09-01), pages 1925 - 1930, XP002556346
GOKMEN V ET AL: "Simultaneous determination of 5-hydroxymethylfurfural and patulin in apple juice by reversed-phase liquid chromatography", JOURNAL OF CHROMATOGRAPHY, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 847, no. 1-2, 25 June 1999 (1999-06-25), pages 69 - 74, XP004171955, ISSN: 0021-9673
GIORDANO L ET AL: "Quantitative analysis of 2-furfural and 5-methylfurfural in different Italian vinegars by headspace solid-phase microextraction coupled to gas chromatography-mass spectrometry using isotope dilution", JOURNAL OF CHROMATOGRAPHY, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 1017, no. 1-2, 31 October 2003 (2003-10-31), pages 141 - 149, XP004463089, ISSN: 0021-9673
PONTES ET AL: "Screening of volatile composition from Portuguese multifloral honeys using headspace solid-phase microextraction-gas chromatography-quadrupole mass spectrometry", TALANTA, ELSEVIER, AMSTERDAM, NL, vol. 74, no. 1, 26 October 2007 (2007-10-26), pages 91 - 103, XP022315328, ISSN: 0039-9140
GASPAR E M S M ET AL: "Improved HPLC methodology for food control - furfurals and patulin as markers of quality", FOOD CHEMISTRY, ELSEVIER SCIENCE PUBLISHERS LTD, GB, vol. 114, no. 4, 15 June 2009 (2009-06-15), pages 1576 - 1582, XP025953394, ISSN: 0308-8146, [retrieved on 20090109]
BERANEK J ET AL: "Evaluation of solid-phase microextraction methods for determination of trace concentration aldehydes in aqueous solution", JOURNAL OF CHROMATOGRAPHY, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 1209, no. 1-2, 31 October 2008 (2008-10-31), pages 44 - 54, XP025546000, ISSN: 0021-9673, [retrieved on 20080910]
FITZGERALD G ET AL: "Characterisation of whiskeys using solid-phase microextraction with gas chromatography-mass spectrometry", JOURNAL OF CHROMATOGRAPHY, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 896, no. 1-2, 27 October 2000 (2000-10-27), pages 351 - 359, XP004218798, ISSN: 0021-9673
KATAOKA H ET AL: "Applications of solid-phase microextraction in food analysis", JOURNAL OF CHROMATOGRAPHY, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 880, no. 1-2, 1 June 2000 (2000-06-01), pages 35 - 62, XP004204839, ISSN: 0021-9673
YANG X. AND T. PEPPARD: "Solid-Phase Microextraction for Flavor Analysis", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 42, no. 9, September 1994 (1994-09-01), pages 1925 - 1930, XP002556346
GOKMEN V ET AL: "Simultaneous determination of 5-hydroxymethylfurfural and patulin in apple juice by reversed-phase liquid chromatography", JOURNAL OF CHROMATOGRAPHY, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 847, no. 1-2, 25 June 1999 (1999-06-25), pages 69 - 74, XP004171955, ISSN: 0021-9673
GIORDANO L ET AL: "Quantitative analysis of 2-furfural and 5-methylfurfural in different Italian vinegars by headspace solid-phase microextraction coupled to gas chromatography-mass spectrometry using isotope dilution", JOURNAL OF CHROMATOGRAPHY, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 1017, no. 1-2, 31 October 2003 (2003-10-31), pages 141 - 149, XP004463089, ISSN: 0021-9673
PONTES ET AL: "Screening of volatile composition from Portuguese multifloral honeys using headspace solid-phase microextraction-gas chromatography-quadrupole mass spectrometry", TALANTA, ELSEVIER, AMSTERDAM, NL, vol. 74, no. 1, 26 October 2007 (2007-10-26), pages 91 - 103, XP022315328, ISSN: 0039-9140
GASPAR E M S M ET AL: "Improved HPLC methodology for food control - furfurals and patulin as markers of quality", FOOD CHEMISTRY, ELSEVIER SCIENCE PUBLISHERS LTD, GB, vol. 114, no. 4, 15 June 2009 (2009-06-15), pages 1576 - 1582, XP025953394, ISSN: 0308-8146, [retrieved on 20090109]
Attorney, Agent or Firm:
VIEIRA PEREIRA FERREIRA, Maria Silvina (Rua Castilho 50-9ยบ, -163 Lisboa, PT)
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