Title:
METHOD FOR ANALYZING GLYCOSAMINOGLYCAN
Document Type and Number:
WIPO Patent Application WO/2018/155443
Kind Code:
A1
Abstract:
[Problem] To provide a method for measuring trace amounts of heparan sulfate and/or dermatan sulfate contained in a sample. [Solution] The present invention provides a method for decomposing heparan sulfate and dermatan sulfate contained in a sample into, respectively, a disaccharide in which uronic acid and amino sugar are α1,4-bonded and a disaccharide in which uronic acid and amino sugar are α1,3-bonded. More particularly, the present invention provides a method for decomposing heparan sulfate and dermatan sulfate by heating the heparan sulfate and the dermatan sulfate in, for example, 2,2-dimethoxypropane-containing methanol hydrochloride at 65-85°C for 80-180 minutes and 60-80°C for 20-100 minutes, respectively.
Inventors:
TANAKA NOBORU (JP)
KIDA SACHIHO (JP)
KIDA SACHIHO (JP)
Application Number:
PCT/JP2018/006043
Publication Date:
August 30, 2018
Filing Date:
February 20, 2018
Export Citation:
Assignee:
JAPAN CHEM RES (JP)
International Classes:
G01N33/66; G01N27/62; G01N30/06; G01N30/88; G01N33/48
Foreign References:
| JP2004168771A | 2004-06-17 | |||
| JP2004210714A | 2004-07-29 | |||
| JP2012108056A | 2012-06-07 |
Other References:
AURAY-BLAIS, C. ET AL.: "Efficient analysis of urinary glycosaminoglycans by LC-MS/MS in mucopolysaccharidoses type I, II and VI", MOLECULAR GENETICS AND METABOLISM, vol. 102, no. 1, January 2011 (2011-01-01), pages 49 - 56, XP027587967
AURAY-BLAIS, C. ET AL.: "An improved method for glycosaminoglycan analysis by LC-MS/MS of urine samples collected on filter paper", CLINICA CHIMICA ACTA, vol. 413, no. 7, 11 April 2012 (2012-04-11), pages 771 - 778, XP028463580
ZHANG, H. Y. ET AL.: "Analysis of glycosaminoglycans in cerebrospinal fluid from patients with mucopolysaccharidoses by isotope-dilution ultra-performance liquid chromatography-tandem mass spectrometry", CLINICAL CHEMISTRY, vol. 57, no. 7, July 2011 (2011-07-01), pages 1005 - 1012, XP055536962
TOIDA, T. ET AL.: "Gas chromatography-mass spectrometric determinations of iduronic and glucuronic acids in glycosaminoglycans after reduction of carboxylic group using sodium borodeuteride", ANALYTICAL SCIENCES, vol. 8, December 1992 (1992-12-01), pages 799 - 804, XP055157574
AURAY-BLAIS C. ET AL., MOL GENET METAB., vol. 102., 2011, pages 49 - 56
AURAY-BLAIS C. ET AL., CLIN CHIM ACTA., vol. 413, 2012, pages 771 - 8
ZANG H. ET AL., CLIN CHEM., vol. 57, 2011, pages 1005 - 12
See also references of EP 3588090A4
AURAY-BLAIS, C. ET AL.: "An improved method for glycosaminoglycan analysis by LC-MS/MS of urine samples collected on filter paper", CLINICA CHIMICA ACTA, vol. 413, no. 7, 11 April 2012 (2012-04-11), pages 771 - 778, XP028463580
ZHANG, H. Y. ET AL.: "Analysis of glycosaminoglycans in cerebrospinal fluid from patients with mucopolysaccharidoses by isotope-dilution ultra-performance liquid chromatography-tandem mass spectrometry", CLINICAL CHEMISTRY, vol. 57, no. 7, July 2011 (2011-07-01), pages 1005 - 1012, XP055536962
TOIDA, T. ET AL.: "Gas chromatography-mass spectrometric determinations of iduronic and glucuronic acids in glycosaminoglycans after reduction of carboxylic group using sodium borodeuteride", ANALYTICAL SCIENCES, vol. 8, December 1992 (1992-12-01), pages 799 - 804, XP055157574
AURAY-BLAIS C. ET AL., MOL GENET METAB., vol. 102., 2011, pages 49 - 56
AURAY-BLAIS C. ET AL., CLIN CHIM ACTA., vol. 413, 2012, pages 771 - 8
ZANG H. ET AL., CLIN CHEM., vol. 57, 2011, pages 1005 - 12
See also references of EP 3588090A4
Attorney, Agent or Firm:
YAMAMOTO, Yoshiki (JP)
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