Title:
METHOD FOR ANALYZING HEART RATE VARIABILITY, APPARATUS AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/036368
Kind Code:
A1
Abstract:
A method for analyzing heart rate variability, and an apparatus and use thereof, the method for analyzing heart rate variability comprising: collecting ECG data in vitro; digitizing and denoising the ECG data; forming the processed ECG data into a sinus NN interval sequence; selecting sinus NN interval data of 4 hours in an awake state; performing MSE calculation on the sinus NN interval sequence of 4 hours in an awake state; and extracting parameters representing the complexity of a heart rate by using MSE curves. The present invention may provide accurate and efficient screening for drug-refractory epilepsy patients who are suitable for vagus nerve stimulation surgery, thus avoiding unnecessary expenses, and avoiding missing the most opportune moment for treatment. At the same time, patients suitable for VNS surgery are selected by using MSE complexity feature parameters of ECG, thus improving the overall efficacy of VNS therapy.
Inventors:
LI LUMING (CN)
LIU HONGYUN (CN)
YANG ZHAO (CN)
LIU HONGYUN (CN)
YANG ZHAO (CN)
Application Number:
PCT/CN2017/095952
Publication Date:
March 01, 2018
Filing Date:
August 04, 2017
Export Citation:
Assignee:
UNIV TSINGHUA (CN)
BEIJING PINS MEDICAL CO LTD (CN)
BEIJING PINS MEDICAL CO LTD (CN)
International Classes:
A61B5/024; A61B5/0245; A61B5/364
Domestic Patent References:
| WO2013016290A2 | 2013-01-31 |
Foreign References:
| CN103251392A | 2013-08-21 | |||
| CN106343992A | 2017-01-25 | |||
| CN106264510A | 2017-01-04 | |||
| CN105574322A | 2016-05-11 | |||
| CN105476630A | 2016-04-13 |
Other References:
HO, YI-LWUN: "The Prognostic Value of Non-Linear Analysis of Heart Rate Variability in Patients with Congestive Heart Failure-A Pilot Study of Mu- ltiscale Entropy", PLOS ONE, vol. 6, no. 4, 13 April 2011 (2011-04-13), pages e18699, XP055603060, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0018699
Attorney, Agent or Firm:
ALLBRIGHT LAW OFFICES (CN)
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