Title:
METHOD FOR ANALYZING METAL PROTEIN IN BIOLOGICAL SAMPLE
Document Type and Number:
WIPO Patent Application WO/2019/198811
Kind Code:
A1
Abstract:
The present invention relates to a method which is for analyzing a metal protein in a biological sample and which can continuously maintain constant conditions of LC-ICPMS to measure a metal protein with high data reliability. This method for analyzing, in a biological sample, a metal protein that is a complex in which a biomolecule and a metal element bind to each other, includes: treating, by liquid chromatography, a biological sample which has been subjected to pretreatment, to separate a metal protein therefrom; and analyzing the separated metal protein through inductively coupled plasma mass spectrometry, wherein an ammonium acetate solution is used as a mobile phase.
Inventors:
YAMAKI SATOSHI (JP)
ZOU YUN (CN)
ZOU YUN (CN)
Application Number:
PCT/JP2019/015950
Publication Date:
October 17, 2019
Filing Date:
April 12, 2019
Export Citation:
Assignee:
SHIMADZU CORP (JP)
International Classes:
G01N30/72; G01N30/88
Foreign References:
| JP2009114105A | 2009-05-28 | |||
| JP2005514737A | 2005-05-19 | |||
| JP2006003347A | 2006-01-05 | |||
| JP2007529755A | 2007-10-25 |
Other References:
LOPEZ-AVILA , VIORICA: "Determination of Ceruloplasmin in Human Serum by Immunoaffinity Chromatography and Size-Exclusion Chromatography-ICP-MS", 31 May 2017 (2017-05-31), pages 1 - 10, XP055642747, Retrieved from the Internet [retrieved on 20190622]
Attorney, Agent or Firm:
KYOTO INTERNATIONAL PATENT LAW OFFICE (JP)
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