Title:
METHOD FOR ANALYZING POSSIBILITY OF CANCER DEVELOPING IN SUBJECT
Document Type and Number:
WIPO Patent Application WO/2024/062867
Kind Code:
A1
Abstract:
A method for analyzing the possibility of cancer developing in a subject according to an embodiment of the present invention comprises: counting, through comparison with a reference sequence, the number of types of RNA in which sequence variations based on RNA editing exist and which is in a sample derived from the subject; and determining the possibility of cancer developing in the subject, by using the obtained number of types of RNA as an index.
Inventors:
ANDO TOMOMI (JP)
ISHIHARA MITSUKO (JP)
SANO YOSHITAKE (JP)
MIYAGAWA TAKUYA (JP)
HASHIMOTO KOJI (JP)
ISHIHARA MITSUKO (JP)
SANO YOSHITAKE (JP)
MIYAGAWA TAKUYA (JP)
HASHIMOTO KOJI (JP)
Application Number:
PCT/JP2023/031406
Publication Date:
March 28, 2024
Filing Date:
August 30, 2023
Export Citation:
Assignee:
TOSHIBA KK (JP)
International Classes:
C12Q1/6886; C12Q1/686; C12Q1/6869; C12Q1/6874; G01N33/53
Domestic Patent References:
| WO2021222647A2 | 2021-11-04 |
Other References:
AISO SATOKO, MAKIKO UEDA, MAKOTO KARIDA, HARUHIKO KONFUJI, HIROSHI OTSUKA, HIROSHI OHNISHI: "Deep sequencing analysis of serum microRNA profiles of lung adenocarcinoma patients", JOURNAL OF THE KYORIN MEDICAL ASSOCIATION, vol. 51, no. 1, 1 March 2020 (2020-03-01), pages 3 - 10, XP093148785
YUN ZHENG;TING LI;REN REN;DONGHUA SHI;SHENGPENG WANG: "Revealing editing and SNPs of microRNAs in colon tissues by analyzing high-throughput sequencing profiles of small RNAs", BMC GENOMICS, BIOMED CENTRAL LTD, LONDON, UK, vol. 15, no. Suppl 9, 8 December 2014 (2014-12-08), London, UK , pages S11, XP021204629, ISSN: 1471-2164, DOI: 10.1186/1471-2164-15-S9-S11
MARCECA GIOACCHINO P., TOMASELLO LUISA, DISTEFANO ROSARIO, ACUNZO MARIO, CROCE CARLO M., NIGITA GIOVANNI: "Detecting and Characterizing A-To-I microRNA Editing in Cancer", CANCERS, CH, vol. 13, no. 7, 3 April 2021 (2021-04-03), CH , pages 1699, XP093148789, ISSN: 2072-6694, DOI: 10.3390/cancers13071699
QIN JIA-XIN, LIU XING, WANG XIN-LEI, WANG GUANG-YUE, LIANG QING, DONG YANG, PANG KUN, HAO LIN, XUE LIANG, ZHAO YAN, HU ZHENG-XIANG: "Identification and analysis of microRNA editing events in recurrent bladder cancer based on RNA sequencing: MicroRNA editing level is a potential novel biomarker", FRONTIERS IN GENETICS, FRONTIERS RESEARCH FOUNDATION, SWITZERLAND, vol. 13, 19 September 2022 (2022-09-19), Switzerland , pages 984279., XP093148791, ISSN: 1664-8021, DOI: 10.3389/fgene.2022.984279
LIN CHUI-HSIEN, CHEN SEAN CHUN-CHANG: "The Cancer Editome Atlas: A Resource for Exploratory Analysis of the Adenosine-to-Inosine RNA Editome in Cancer", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 79, no. 11, 1 June 2019 (2019-06-01), US, pages 3001 - 3006, XP093148792, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-18-3501
YUN ZHENG;TING LI;REN REN;DONGHUA SHI;SHENGPENG WANG: "Revealing editing and SNPs of microRNAs in colon tissues by analyzing high-throughput sequencing profiles of small RNAs", BMC GENOMICS, BIOMED CENTRAL LTD, LONDON, UK, vol. 15, no. Suppl 9, 8 December 2014 (2014-12-08), London, UK , pages S11, XP021204629, ISSN: 1471-2164, DOI: 10.1186/1471-2164-15-S9-S11
MARCECA GIOACCHINO P., TOMASELLO LUISA, DISTEFANO ROSARIO, ACUNZO MARIO, CROCE CARLO M., NIGITA GIOVANNI: "Detecting and Characterizing A-To-I microRNA Editing in Cancer", CANCERS, CH, vol. 13, no. 7, 3 April 2021 (2021-04-03), CH , pages 1699, XP093148789, ISSN: 2072-6694, DOI: 10.3390/cancers13071699
QIN JIA-XIN, LIU XING, WANG XIN-LEI, WANG GUANG-YUE, LIANG QING, DONG YANG, PANG KUN, HAO LIN, XUE LIANG, ZHAO YAN, HU ZHENG-XIANG: "Identification and analysis of microRNA editing events in recurrent bladder cancer based on RNA sequencing: MicroRNA editing level is a potential novel biomarker", FRONTIERS IN GENETICS, FRONTIERS RESEARCH FOUNDATION, SWITZERLAND, vol. 13, 19 September 2022 (2022-09-19), Switzerland , pages 984279., XP093148791, ISSN: 1664-8021, DOI: 10.3389/fgene.2022.984279
LIN CHUI-HSIEN, CHEN SEAN CHUN-CHANG: "The Cancer Editome Atlas: A Resource for Exploratory Analysis of the Adenosine-to-Inosine RNA Editome in Cancer", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 79, no. 11, 1 June 2019 (2019-06-01), US, pages 3001 - 3006, XP093148792, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-18-3501
Attorney, Agent or Firm:
S & S INTERNATIONAL PPC (JP)
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