METHOD OF ANALYZING PROBE SUPPORT BY USING FLYING TIME SECONDARY ION MASS SPECTROMETRY

WIPO Patent Application WO/2004/003532

A1

It is intended to provide a method of analyzing a measurement sample whereby the conditions of a probe located on a support and the occurrence/non-occurrence of the formation of a hybrid of the probe with a target nucleic acid (for example, imaging of the locations and quantitative analysis thereof) can be accurately analyzed. Namely, the conditions of a nucleic acid probe formed in a measurement sample in which a sample is reacted with a probe support and the occurrence/non-occurrence of the formation of a hybrid of the probe with a target nucleic acid are analyzed by the flying time secondary ion mass spectrometry in a state labeled with a label capable of forming a fragment ion which is not formed by the fragmentation of the probe and/or the target.

OKAMOTO TADASHI (JP)
TAKASE HIROMITSU (JP)
HASHIMOTO HIROYUKI (JP)

PCT/JP2003/008104

January 08, 2004

June 26, 2003

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CANON KK (JP)
OKAMOTO TADASHI (JP)
TAKASE HIROMITSU (JP)
HASHIMOTO HIROYUKI (JP)

C12Q1/68; G01N23/225; (IPC1-7): G01N23/225; G01N33/53

WO1998059362A1

1998-12-30

US5821060A	1998-10-13
JPH10132802A	1998-05-22
JPS6111665A	1986-01-20

ARLINGHAUS H.F. ET AL.: "Analysis of biosensor chips for identification of nucleic acids", ANALYTICAL CHEMISTRY, vol. 69, no. 18, 15 September 1997 (1997-09-15), pages 3747 - 3753, XP002973382
See also references of EP 1519189A4

Okabe, Masao (Fuji Bldg. 2-3, Marunouchi 3-chom, Chiyoda-ku Tokyo, JP)

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