Title:
METHOD FOR ANALYZING PROTEINS CONTRIBUTING TO AUTOIMMUNE DISEASES, AND METHOD FOR TESTING FOR SAID DISEASES
Document Type and Number:
WIPO Patent Application WO/2012/067165
Kind Code:
A1
Abstract:
[Problem] To provide a method for detecting a myriad of proteins that contribute to autoimmune diseases with high sensitivity and high efficiency, and a method for analyzing the data obtained as a result of the detection method. [Solution] In order to construct the abovementioned detection method and analysis method, a means is provided for detecting autoantibody production by bringing mammal-derived proteins derived, which are expressed by a cell-free protein synthesis system, into contact with samples derived from patients with autoimmune diseases, and for comprehensively analyzing the proteins that contribute to autoimmune diseases by statistically analyzing the detected data, and performing gene ontology analysis and/or pathway analysis.
Inventors:
SAWASAKI TATSUYA (JP)
ENDO YAETA (JP)
ISHIGAMI TOMOAKI (JP)
AOKI ICHIRO (JP)
ENDO YAETA (JP)
ISHIGAMI TOMOAKI (JP)
AOKI ICHIRO (JP)
Application Number:
PCT/JP2011/076450
Publication Date:
May 24, 2012
Filing Date:
November 16, 2011
Export Citation:
Assignee:
NAT UNIV CORP EHIME UNIV (JP)
PUBLIC UNIV CORP YOKOHAMA CITY (JP)
SAWASAKI TATSUYA (JP)
ENDO YAETA (JP)
ISHIGAMI TOMOAKI (JP)
AOKI ICHIRO (JP)
PUBLIC UNIV CORP YOKOHAMA CITY (JP)
SAWASAKI TATSUYA (JP)
ENDO YAETA (JP)
ISHIGAMI TOMOAKI (JP)
AOKI ICHIRO (JP)
International Classes:
G01N33/53; G01N21/64; G01N33/543
Foreign References:
| JP2009544971A | 2009-12-17 | |||
| JP2009503529A | 2009-01-29 | |||
| JP2008501636A | 2008-01-24 |
Other References:
BINDER,C.J. ET AL.: "The role of natural antibodies in atherogenesis", J.LIPID RES., vol. 46, no. 7, 2005, pages 1353 - 1363
MASATO NOSE ET AL.: "Nanchisei Kekkan'en ni Kansuru Chosa Kenkyu Musaibo Tanpakushitsu Goseikei ni yoru Jiko Kotai no Screening-ho to Kanben na ELISA-ho no Kakuritsu", NANCHISEI KEKKAN'EN NI KANSURU CHOSA KENKYU HEISEI 19 NENDO SOKATSU BUNTAN KENKYU HOKOKUSHO, 2008, pages 53 - 56
MASATO NOSE ET AL.: "Nanchisei Kekkan'en ni Kansuru Chosa Kenkyu Musaibo Tanpakushitsu Goseikei ni yoru Jiko Kotai no Screening-ho to Kanben na ELISA-ho no Kakuritsu", NANCHISEI KEKKAN'EN NI KANSURU CHOSA KENKYU HEISEI 19 NENDO SOKATSU BUNTAN KENKYU HOKOKUSHO, 2008, pages 53 - 56
Attorney, Agent or Firm:
SHOJI, Takashi et al. (JP)
Takashi Shoji (JP)
Takashi Shoji (JP)
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Claims: