Title:
METHOD AND APPARATUS FOR ACQUIRING POSITRON EMISSION TOMOGRAPHY DATA IN FULL BEAM HADRON THERAPY
Document Type and Number:
WIPO Patent Application WO/2019/138384
Kind Code:
A1
Abstract:
Apparatus for acquiring positron emission tomography data when irradiating an object (20) with a hadron beam (B), the apparatus comprising a plurality of detectors (10) and a data processing system (12, 15). The data processing system (12, 15) is configured to process the detection data according to the following steps: a) determining a temporal distribution of the coincidence event rate acquired by the respective detector (10), b) sampling each spill interval with a sampling frequency of the order of magnitude of GHz to obtain a respective fine grained event rate distribution; c) for each spill interval: - c1) analysing frequencies of the fine grained event rate distribution to find an initial frequency value fo compatible with the radiofrequency signal of the hadron beam; - c2) from the initial frequency value, estimating period Ts of the micro-bunches and transforming time values of the coincidence events in the spill interval into values of phase relative to an arbitrary phase, based on the estimated period of the micro-bunches; and - c3) at each micro-bunch of the spill interval, executing filtering to remove coincidence events around a peak associated with background noise induced by the hadron beam and keep the remaining coincidence events of the micro-bunch.
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Inventors:
SPORTELLI GIANCARLO (IT)
BISOGNI MARIA GIUSEPPINA (IT)
KOSTARA ELEFTHERIA (GR)
MORROCCHI MATTEO (IT)
CAMARLINGHI NICCOLÒ (IT)
BISOGNI MARIA GIUSEPPINA (IT)
KOSTARA ELEFTHERIA (GR)
MORROCCHI MATTEO (IT)
CAMARLINGHI NICCOLÒ (IT)
Application Number:
PCT/IB2019/050258
Publication Date:
July 18, 2019
Filing Date:
January 14, 2019
Export Citation:
Assignee:
UNIV PISA (IT)
ISTITUTO NAZ FISICA NUCLEARE (IT)
ISTITUTO NAZ FISICA NUCLEARE (IT)
International Classes:
G01T1/29; A61N5/10
Other References:
LESTAND LOIC ET AL: "In Beam PET Acquisition on 75 MeV. $\text {u}^{-1}$ Carbon Beam Using Sampling-Based Read-Out Electronics", IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES, IEEE, vol. 1, no. 1, 1 January 2017 (2017-01-01), pages 87 - 95, XP011642479, ISSN: 2469-7311, [retrieved on 20170306], DOI: 10.1109/TNS.2016.2635584
PARODI K ET AL: "Random coincidences during in-beam PET measurements at microbunched therapeutic ion beams", NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH. SECTION A, ELSEVIER BV * NORTH-HOLLAND, NL, vol. 545, no. 1-2, 11 June 2005 (2005-06-11), pages 446 - 458, XP027781751, ISSN: 0168-9002, [retrieved on 20050611]
BARTHEL T ET AL: "Suppression of Random Coincidences During In-Beam PET Measurements at Ion Beam Radiotherapy Facilities", IEEE TRANSACTIONS ON NUCLEAR SCIENCE, IEEE SERVICE CENTER, NEW YORK, NY, US, vol. 52, no. 4, 1 August 2005 (2005-08-01), pages 980 - 987, XP011137769, ISSN: 0018-9499, DOI: 10.1109/TNS.2005.852637
PARODI K ET AL: "Random coincidences during in-beam PET measurements at microbunched therapeutic ion beams", NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH. SECTION A, ELSEVIER BV * NORTH-HOLLAND, NL, vol. 545, no. 1-2, 11 June 2005 (2005-06-11), pages 446 - 458, XP027781751, ISSN: 0168-9002, [retrieved on 20050611]
BARTHEL T ET AL: "Suppression of Random Coincidences During In-Beam PET Measurements at Ion Beam Radiotherapy Facilities", IEEE TRANSACTIONS ON NUCLEAR SCIENCE, IEEE SERVICE CENTER, NEW YORK, NY, US, vol. 52, no. 4, 1 August 2005 (2005-08-01), pages 980 - 987, XP011137769, ISSN: 0018-9499, DOI: 10.1109/TNS.2005.852637
Attorney, Agent or Firm:
VANZINI, Christian et al. (IT)
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