Title:
METHOD AND APPARATUS FOR ANALYZING A LIQUID SAMPLE BY RAMAN SPECTROSCOPY
Document Type and Number:
WIPO Patent Application WO/2012/112119
Kind Code:
A8
Abstract:
A liquid sample containing multiple analytes is used to produce a layer on a SERS surface of an SERS substrate. Raman spectra are collected from the different locations. The Raman spectra for different locations have different ratios of signal components from the multiple respective analytes, for example because the analytes are present in different proportions at the different locations, or because the analytes interact with the SERS surface in different ways at the different locations. A self-modeling curve resolution technique such as BTEM is used to extract from the collected Raman spectra multiple pure component spectra, corresponding to the respective analyte components. The pure component spectra can be used to identify the analytes. One way of producing the inhomogenous layer is by evaporating the liquid sample. Another is by arranging for the surface of the SERS substrate to be inhomogeneous, so that an inhomogenous layer of adsorbed analytes is formed and/or such that the SERS effect itself is inhomogenous.
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Inventors:
NIZAMUDIN MD KHALID (SG)
SALIM SHAIK (SG)
WIDJAJA EFFENDI (SG)
LIM GEOK HONG (SG)
GARLAND MARC (SG)
AGARWAL AJAY (SG)
FANG CHENG (SG)
BUDDHARAJU KAVITHA DEVI (SG)
SALIM SHAIK (SG)
WIDJAJA EFFENDI (SG)
LIM GEOK HONG (SG)
GARLAND MARC (SG)
AGARWAL AJAY (SG)
FANG CHENG (SG)
BUDDHARAJU KAVITHA DEVI (SG)
Application Number:
PCT/SG2011/000065
Publication Date:
October 11, 2012
Filing Date:
February 16, 2011
Export Citation:
Assignee:
AGENCY SCIENCE TECH & RES (SG)
NIZAMUDIN MD KHALID (SG)
SALIM SHAIK (SG)
WIDJAJA EFFENDI (SG)
LIM GEOK HONG (SG)
GARLAND MARC (SG)
AGARWAL AJAY (SG)
FANG CHENG (SG)
BUDDHARAJU KAVITHA DEVI (SG)
NIZAMUDIN MD KHALID (SG)
SALIM SHAIK (SG)
WIDJAJA EFFENDI (SG)
LIM GEOK HONG (SG)
GARLAND MARC (SG)
AGARWAL AJAY (SG)
FANG CHENG (SG)
BUDDHARAJU KAVITHA DEVI (SG)
International Classes:
G01N21/65; G01J3/44
Attorney, Agent or Firm:
WATKIN, Timothy, Lawrence, Harvey (Tanjong PagarP.O. Box 636, Singapore 6, SG)
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