Title:
METHOD, APPARATUS AND ARTICLE FOR MICROFLUIDIC CONTROL VIA ELECTROWETTING, FOR CHEMICAL, BIOCHEMICAL AND BIOLOGICAL ASSAYS AND THE LIKE
Document Type and Number:
WIPO Patent Application WO2003045556
Kind Code:
A3
Abstract:
An active matrix microfluidic platform employs thin film transistor active ("TFT") matrix liquid crystal display technology to manipulate small samples of fluid for chemical, biochemical, or biological assays without moving parts, for example, using a two-dimensional matrix array of drive electrodes. The active matrix microfluidic platform may employ existing active matrix addressing schemes and/or commercial "off-the-shelf" animation software to program assay protocols. A feedback subsystem may determine an actual location of a fluid in the microfluidic structure, and provides location information to for display, for example, on an active matrix display, and/or to control movement of one or more fluid bodies in the microfluidic structure.
Inventors:
STERLING JAMES D (US)
Application Number:
PCT/US2002/038047
Publication Date:
April 15, 2004
Filing Date:
November 26, 2002
Export Citation:
Assignee:
KECK GRADUATE INST (US)
STERLING JAMES D (US)
STERLING JAMES D (US)
International Classes:
B01J19/00; B01L3/00; F04B17/00; F04B19/00; G01N1/00; F04F99/00; G01N35/00; G01N35/08; G01N37/00; (IPC1-7): B01L3/00; G02F1/00; F04B19/00; B03C5/00
Domestic Patent References:
WO2002007503A1 | 2002-01-31 | |||
WO2000069565A1 | 2000-11-23 |
Foreign References:
US20010026935A1 | 2001-10-04 | |||
US6294063B1 | 2001-09-25 | |||
US5495077A | 1996-02-27 |
Other References:
JUNGHOON LEE ET AL: "Addressable micro liquid handling by electric control of surface tension", PROCEEDINGS OF THE IEEE 14TH. ANNUAL INTERNATIONAL CONFERENCE ON MICROELECTRO MECHANICAL SYSTEMS. MEMS 2001. INTERLAKEN, SWITZERLAND, JAN. 21 - 25, 2001, IEEE INTERNATIONAL MICRO ELECTRO MECHANICAL SYSTEMS CONFERENCE, NEW YORK, NY: IEEE, US, vol. CONF. 14, 21 January 2001 (2001-01-21), pages 499 - 502, XP010534657, ISBN: 0-7803-5998-4
POLLACK M G ET AL: "ELECTROWETTING-BASED ACTUATION OF LIQUID DROPLETS FOR MICROFLUIDIC APPLICATIONS", APPLIED PHYSICS LETTERS, AMERICAN INSTITUTE OF PHYSICS. NEW YORK, US, vol. 77, no. 11, 11 September 2000 (2000-09-11), pages 1725 - 1727, XP000964197, ISSN: 0003-6951
CHO S K, MOON H, FOWLER J, KIM CJ: "Splitting a liquid droplet for electrowetting-based microfluidics", PROCEEDINGS OF 2001 ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION, NOVEMBER 11-16, 2001, NEW YORK, vol. CONF, 16 November 2001 (2001-11-16), pages 1 - 7, XP002242357
SUNG KWON CHO ET AL: "Towards digital microfluidic circuits: creating, transporting, cutting and merging liquid droplets by electrowetting-based actuation", IEEE 0-7803-7185-2/02, 2002, pages 32 - 35, XP010577588
POLLACK M G ET AL: "ELECTROWETTING-BASED ACTUATION OF LIQUID DROPLETS FOR MICROFLUIDIC APPLICATIONS", APPLIED PHYSICS LETTERS, AMERICAN INSTITUTE OF PHYSICS. NEW YORK, US, vol. 77, no. 11, 11 September 2000 (2000-09-11), pages 1725 - 1727, XP000964197, ISSN: 0003-6951
CHO S K, MOON H, FOWLER J, KIM CJ: "Splitting a liquid droplet for electrowetting-based microfluidics", PROCEEDINGS OF 2001 ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION, NOVEMBER 11-16, 2001, NEW YORK, vol. CONF, 16 November 2001 (2001-11-16), pages 1 - 7, XP002242357
SUNG KWON CHO ET AL: "Towards digital microfluidic circuits: creating, transporting, cutting and merging liquid droplets by electrowetting-based actuation", IEEE 0-7803-7185-2/02, 2002, pages 32 - 35, XP010577588
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