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Title:
METHOD AND APPARATUS FOR DETERMINING BLOOD-BRAIN BARRIER CLOSING TIME, ELECTRONIC DEVICE, AND MEDIUM
Document Type and Number:
WIPO Patent Application WO/2023/000428
Kind Code:
A1
Abstract:
Disclosed in embodiments of the present application are a method and apparatus for determining a blood-brain barrier closing time, an electronic device, and a medium. The method comprises: respectively obtaining magnetic resonance longitudinal relaxation time maps corresponding to multiple contrast agent injection moments of a target brain region in the process of opening the blood-brain barrier in the target brain region of a target object by means of magnetic resonance guided ultrasound; determining a blood-brain barrier opening region of the target brain region and a muscle tissue region and a blood-brain barrier closing region corresponding to the blood-brain barrier opening region; for each magnetic resonance longitudinal relaxation time map, respectively determining magnetic resonance longitudinal relaxation times of the blood-brain barrier opening region, the muscle tissue region, and the blood-brain barrier closing region; respectively determining contrast agent concentrations of the regions on the basis of the magnetic resonance longitudinal relaxation times; and determining a closing time of the blood-brain barrier opening region according to the contrast agent concentrations of the regions corresponding to the multiple injection moments.

Inventors:
ZHENG HAIRONG (CN)
ZHOU HUI (CN)
LIU XIN (CN)
ZOU CHAO (CN)
QIAO YANGZI (CN)
Application Number:
PCT/CN2021/113719
Publication Date:
January 26, 2023
Filing Date:
August 20, 2021
Export Citation:
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Assignee:
SHENZHEN INST OF ADV TECH CAS (CN)
International Classes:
A61B5/055; A61B5/00; A61M37/00; G06T7/00; G06T7/73
Foreign References:
CN110133553A2019-08-16
CN111248869A2020-06-09
US20150073260A12015-03-12
US20190350486A12019-11-21
Other References:
YUAN LIXIA: "Data Analysis of Magnetic Resonance Functional Imaging Based on Hemodynamics and Echo-planar Technique", WANFANG DATA KNOWLEDGE SERVICE PLATFORM, 18 September 2018 (2018-09-18), XP093026641
Attorney, Agent or Firm:
BEYOND ATTORNEYS AT LAW (CN)
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