FIELD OF THE INVENTION The field of the invention is the field of allergy prevention and control.

OBJECTS OF THE INVENTION It is an object of the invention to produce methods, materials, apparatus, and systems for preventing and controlling allergic reactions in mammalian animals before they have exhibited such allergic reactions.

It is an object of the invention to produce methods, materials, apparatus, and systems for preventing and controlling allergies using common household and farm articles to deliver antigens.

BACKGROUND OF THE INVENTION Allergic diseases in general and asthma in particular are on the rise in western societies.

From 1980 to 1994, the U. S. Center for Disease Control and Prevention reported that asthma rates in the US increased by 75%. The International Study of Asthma and Allergy in Childhood (ISAAC) and the European Community Respiratory Health Survey (ECRHS), looking to adult respiratory disease, have recently confirmed that allergic diseases are mainly found in industrialized communities and are far rarer in rural Russia, China, India and Ethiopia.

Allergic diseases are thought to be the result of inflammatory processes characterized by hypersensitive or exaggerated reactions to common allergens or antigens. Other classes of inappropriate inflammatory processes known as autoimmune diseases are also on the rise in western civilization. For example, Crohn's disease, diabetes mellitus type 1, rheumatoid arthritis and systemic lupus erythematosus have all shown significant increases in the last two decades.

Current therapies for allergic diseases are limited to symptom relief and at reducing inflammation mediators. In the case of asthma, for example, typical therapy calls for inhaled corticosteroids, anti-leukotrienes, or receptor agonists. There is a clear lack of therapies designed to prevent the development of allergic and auto-immune diseases before the first symptoms of the disease occurs.

DETAILED DESCRIPTION OF THE INVENTION Several approaches have been proposed for primary prevention of both allergic diseases and autoimmune diseases (before symptoms of the disease occur). which attempt to induce tolerance by administering allergens subcutaneously (as in the case of immunotherapy for hyposensitization) or orally (as in the case of oral tolerance induction). For subcutaneous immunotherapy, Warner et al. (Warner, JO et al. , Lancet2: 912, 1978) showed that by hyposensitizing subjects with a preparation of tick antigens, one could inhibit a delayed asthmatic reaction to inhaled tick antigens. Other studies have also shown that by hyposensitizing subjects with preparations of ragweed pollen, one could inhibit hypersensitive reactions during flowering seasons.

Oral tolerance induction dates as far back as the early customs of the American Indians.

Dakin (Dakin, R, Am. J. Med. Sci, 4: 98,1829) documents how lacquer artisans among the Indians fed their children small amounts of lacquer over an extended period of time to reduce the likelihood of being poisoned later in life. Patricia et al. (Patricia, G et al., Food Allergy, p. 131, 1979) disclosed a method whereby patients allergic to milks, eggs, or fruits were given these items starting with very low amounts and gradually increasing the amounts over time. Others have since demonstrated the effectiveness of inducting oral tolerance using other foods.

For food allergies, serious symptoms are usually caused by very small amounts of allergens, and so many foods are not amenable to the method prescribed by Patricia et al. Others have developed ways in which oral tolerance can still be induced without triggering an allergic responses to the allergen being used to induce tolerance. US patent 5863561 teaches a method for producing milk which contains allergens in a form that does not cause serious hypersensitive reactions but confers tolero-genic protection. The ability of many allergens administered orally to induce tolerance is destroyed by the digestive enzymes and functions of the gut. To overcome this limitation, others have found a way to deliver allergens to the gut while preserving their immunogenicity. US patent publication 20030003133 teaches a method to induce immune tolerance for common allergens by delivering allergens to the gut mucosa via milk. Presumably the milk protects the allergen against the degradative environment of the gastrointestinal tract.

The limitation with this approach is that milk is required to delivery the allergen. US publication 20030180272 further teaches a method where probiotic bacteria are administered to children pre- and postnatally.

Oral tolerance does not have to be limited to food allergen. Wells et al. (Wells, HG et al, <BR> <BR> J. Infect. Dis. , 8: 566, 1991) showed that when fed ovalbumin, normal guinea pigs would develop an immunological tolerance to ovalbumin. Other researchers have shown that when allergens are administered orally, they too induce immunological tolerance (Aramaki, Y et et, Immunol. Lett., 40: 21, 1994).

For autoimmune diseases, the induction of oral tolerance can relieve symptoms of an over-aggressive immune system. Trentham et al. (Trentham, DE et al, Science, 261: 1727, 1993) showed that by orally administering a preparation of Fowl II collagens to patients with rheumatoid arthritis, not only did the symptoms attenuate in many individuals, many of the patients recovered completely from their diseases. US patent publication 20030039666 further teaches the use of parasitic biological agents for prevention and control of auto-immune diseases.

The methods described thus far induce tolerance via proactive administration of allergens to subjects subcutaneously, parenterally or orally. These methods have had limited adoption because they require significant behavioral changes on the part of the subject in order to acquire tolerance. That is, subjects must vigilantly take doses of allergens in a strictly prescribed manner over time before tolerance is achieved.

Recent evidence suggests that certain environments protect against the primary development of allergic and autoimmune diseases. Strachan (Strachan, DP, British Medical Journal, 1989) showed epidemiologic data that increasing hygiene levels between populations is correlated to higher incidences of hay fever. This observation launched a series corroborating studies in Germany after the reunification in 1989. For example, von Mutius et al showed that in genetically similar populations, the prevalence of asthma and allergies was 164% higher among school children living in the former West (Munich) as compared with the children in former East Germany (Leipzig and Halle). Other studies demonstrating this East-West gradient and ruling out obvious factors such as pollution and tobacco use have since been published and are reviewed by L. C. von Hertzen and T. Haahtela (Hertzen, LC and Haahtela, T, Allergy 2004: 59: 124-137).

To explain these epidemiologic findings, a growing number of scientists proposed that the western lifestyle has succeeded in markedly decreasing the incidence of infections in early life, and these infections may have a protective effect on the subsequent development of allergies. Thus the decrease in the number of infections has resulted in an increase in risk for asthma, allergies and many autoimmune diseases later in life. This view led to the coining of the phrase the'hygiene hypothesis'to explain the inverse relation between the incidence of infectious diseases and allergies.

More recent findings have brought into question the role of early childhood infections in reducing allergies. Between 2000 and 2002 studies compared the asthma and allergy rates between populations of children with different infection rates. The results were contradictory.

While some authors reported that contagious diseases such as measles were associated with decreased likelihood of developing allergic conditions, other researchers were unable to confirm these observations. Similar contradictory results were reported for other early childhood infectious diseases. The idea that tolerance is induced through infections has been largely discredited by these findings.

However, a new area of research focusing on the farming environment has led to a revised statement of the hygiene hypothesis. While infections have been ruled out as the determining factor, studies have consistently found that growing up on farms is anticorrelated with development of asthma and allergies. Several of these studies showed that the best correlation factor in the prevalence of allergies among children living on farms and those living in the same rural villages, but not on a farm, was having contact with substances produced by <BR> <BR> farm animals (Von Ehrenstein et el. , Braun-Fahrlander et al., Riedler et al. , Ernst et al. ). It is now known from molecular analysis that these substances are a blend of proteins (which are also allergens) ranging from lipopolysaccharides from bacterial cell wall to the major allergens of the cat, cow and chicken. It is also now known that these proteins have the unique ability to either induce tolerance against a wide variety of common allergens via cross-reactivity or suppress the Helper T cell Type 2 response (Helper T cell Type 2 are responsible for allergic sensitization). In other words, early and sustained exposure to these proteins allows the immune system to be more robust and tolerant of its environment.

The finding that it is probably the exposure to animal proteins and possibly other proteins of non-animal origin, rather than infections, early in life that confers protection against allergic diseases presents an entirely new framework for understanding the hygiene hypothesis. It also provides an opportunity for the present invention which extends induced tolerance to new applications which are not limited to proactive administration of allergens.

Specifically, the present invention improves on the existing methods to prevent primary development of allergic or autoimmune diseases by using common household or farm products and articles to release low dosages of proteins into the environment in such a way as to induce tolerance. By using such household or farm products, one can change the living environment of an infant human or mammalian farm animals to mimic the farming environments that have been significantly correlated with reduced disease risk.

The immune system of a vertebrate mammalian animal such as a human being has two types of cells: T cell and B cells. In general, T cells kill microbes and B cells produce antibodies and these antibodies neutralize microbes or foreign matter. We will now use the term antigen in this application to refer to anything that is not a natural part the animal's body.

Antigens therefore elicit an immune response.

Any single T cell or B cell can only recognize a specific pattern on an antigen. That's why antibodies against snake venom will not neutralize bacteria. Similarly, a T cell that recognizes a particular flu strain will not recognize a different flu strain. Every single day, the body produces new T cells and B cells. The pattern a particular new T cell or B cell can recognize is determined through a random process where 1 out of about 6 billion patterns are selected for a new cell.

Some of the 6 billion patterns are self-patterns. Self-patterns are patterns of normal animal tissue or parts of the animal body, so if the immune system cells recognize such cells, they would attack the cells which would lead to some sort of auto-immune disease.

To prevent auto-immunity, immature immune cells that by chance get a self-pattern and recognize a natural part of the body are killed by the body while they are still immature. Killing of such immature cells does not produce an immune response in the body. At the end of each day, immune system cells that recognize self and non-self have been produced, and the self-recognizing cells have been mostly killed off to leave only non-self recognizing cells.

There are many substances that are not naturally produced by the body, but are inhaled and/or ingested often. When the dose of the substances is great enough, the immune system cells which recognize them are killed off just as the cells which recognize self are killed off.

Such substances do not provoke an immune response.

Substances which are ingested rarely or occasionally in an insufficient dose where the immune system cells which would recognize have a chance to mature before meeting the substance may provoke an immune response from the now mature cells, which are not killed by the body if they recognize an intruder, and which may provoke an inflamation response which we characterize as an allergic response.

We surmise that there domestic animals and humans in particular live in a much cleaner environment than previously, so that more types of immature immune system cells which would recognize strange patterns live to maturity. The way to prevent such allergies is to make sure that the body ingests a therapeutic dose of the common allergy inducing allergens before the body"becomes allergic"to them.

In particular, we suggest that neo-natal vertebrate animals such as humans, domestic animals, and fish, be exposed to allergens before their immune systems are developed. We define a"neo-natal"animal for the purposes of this specification as the animal from birth to the time when the animals immune system is fully developed. In humans, for example, babies are born with few antibodies of their own, and use the mother's antibodies for the first six weeks or so of their life. The critical period for human infants is the first three years of their life, although the immune system continues to develop and mature for a decade.

A therapeutic dose of an antigen is a dose which leads to an antigen density in the body sufficient that an immature immune system cell would probably meet and recognize the antigen before it matures, and would hence be eliminated from the body before it matures to be part of the immune system.

The most preferred embodiment of the invention is to provide antigens for the most common and dangerous allergies. In particular, allergies to peanuts appear very early in the life of human infants, as early as 1 year old. If the infant under the age of 1 is dosed regularly with a peanut antigen, such allergies will be avoided.

Peanut (Arachis hypogaea) Among food allergies, peanut allergy is common and severe.

Epidemiologic studies of the general population estimate a prevalence rate of 0.5%, and peanut allergy accounts forl 0-47% of food-induced anaphylactic reactions. Symptoms may vary in severity from mild urticaria or localized oral symptoms, to severe systemic reactions that can be fatal. Reactions typically occur within a few minutes following ingestion. Peanut hypersensitivity usually begins in early childhood and usually persists throughout life, with only a small percentage of young children achieving tolerance.

A novel method for providing a therapeutic dose of antigen sufficient to protect against allergies is to provide common articles of clothing, bedding, toys, or food with the antigen. In particular, baby clothes, bedding, and toys are proposed as carriers for such antigens. In addition, common substances such as baby powder and formula are admixed with sufficient antigen to give a therapeutic dose to the infant on a sufficiently regular basis that immune system cells recognizing the antigens would be unlikely to survive to maturity.

Strips of material comprising a matrix holding an antigen are preferably sewn into clothing or blankets which are designed to be in close contact with the skin, so that the subjects ingest the antigen through the skin or by breathing. The strips preferably release their antigen in a continuous and controlled manner. The antigen material is preferably encapsulated in a coating which releases the antigen over time and/or upon certain events, such as washing or abrading the article. Such coatings are known, for example, in the art of controlled release drugs. In a preferred example, the encapsulation material is a polymer material. For example, the strips are constructed so that each washing of the article and associated strip exposes new antigen.

Alternatively, material for bedding or clothing may be woven admixed with an antigen such as cat hair. Stuffed animal and other soft toys are particularly preferred as delivery vehicles for antigens.

The antigens preferred for presenting are preferably antigens derived from materials chosen from the following list.

Cereal products Barley (Hordeum vulgare) Buckwheat (Fagopyrum escutentum) Gluten Maize (Zea mays) Oats (Avena sativa) Rice (Oryza sativa) Rye (Secale cereale) Wheat (Triticum aestivum) Drugs Insulin Bovine Insulin Human Insulin Porcine Penicilloyl G Penicilloyl V Suxamethonium (succinylcholine) Egg and Fowl Chicken meat (Gallus spp Egg white Egg yolk Hen's Egg White (Gallus domesticus) Hen's Egg White: Ovomucoid Ovalbumin Ovomucoid Turkey meat (Meleagris gallopavo) Epithelia and Feather Budgie Droppings Budgie Feathers Budgie Serum Proteins Cat Dander Cat dander/Cat saliva (Felis domesticus) Cat serum albumin Chicken Feathers Cow-dander Cow Dander Dog (Canis familiaris) Dog-serum albumin Dog Dander Dog Epithelium Duck Feathers Goat Epithelium Goose Feathers Guinea-pig Epithelium Hamster Epithelium Hedgehog (Erinaceus europaeus) Horse-epithelium/dander (Equus caballus) Horse Dander Mouse (mix) Mouse Epithelium Mouse Serum Proteins Mouse Urine Proteins Pigeon Droppings Rabbit Epithelium Rat (mix) Rat Epithelium Rat Serum Proteins Rat Urine Proteins Sheep Epithelium Swine-serum albumin Swine Epithelium Fruits Apple (Malus domestica) Apple Apricot Banana Blackberry (Rubus fruticosus) Blueberry Carambola (Averrhoa carambola) Cherry Cranberry (Vaccinium oxycoccus, family Ericaceae) Date (Phoenix dactylifera) Grape Grapefruit Guava Kiwi Fruit (Actinidia chinensis) Kiwi fruit Lemon Lime Mandarin (Tangerine, Clementine, Satsumas) Mango Melons Orange Papaya, Pawpaw Passion fruit, Grenadilla Peach Pear Persimmon (Khaki fruit, Sharon) (Diospyros kaki) Pineapple Plum Strawberry (Fragaria vesca) Grass Pollen Bahia grass (Paspalum notatum) Bahia grass (Paspalum notatum) Barley pollen (Hordeum vulgare) Bermuda grass (Cynodon dactylon) Bermuda grass (Cynodon dactylon) Brome grass (Bromus inermis) Brome grass/Rescue grass (Bromus inermis) Bulbous Canary grass/Toowoomba Canary grass (Phalaris aquatica) Bunny tail grass (Lagurus ovatus) Canary Grass (Phalaris arundinacea) Canary grass/Reed Canary grass (Phalaris arundinacea) Cattail (Typhaceae) <BR> <BR> Chickling Vetch/Grass Pea/Blue Vetch (Lathyrus sativus) Chicory (Cichorium intybus) <BR> <BR> Cocksfoot/Orchard (Dactylis glomerata) Cocksfoot/Orchard (Dactylis glomerata) Cocksfoot grass/Dactylis/Orchard (Dactylis glomerata) Common reed (Phragmites communis) Common Reed (grass) (Phragmites communis) Common wild oats Common wild sorghum (Sorghum bicolor) Cottonwool grass (Imperata cylindrica) Cultivated Oat (Avena sativa) Cultivated oats (Avena sativa) Cultivated rye (Secale cereale) Cultivated Rye grass (Secale cereale) Cultivated Wheat (Triticum sativum) English Bunch grass (Cenchrus ciliaris) False Oat grass (Arrhenatherum elatius) Foxtail Millet (Setaria italic) Grass Family (Poaceae) Hairy wild lettuce (Hypochoeris radicata) Johnson grass (Sorghum halepense) Johnson grass (Sorghum halepense) Johnson grass (Sorghum halepense) Kikuyu (Pennisetum clandestinum) Maize pollen/Corn pollen (Zea mays) Meadow fescue (Festuca elatior) Meadow Fescue grass (Festuca elator) Meadow foxtail (Alopecurus pratensis) Meadow Foxtail grass (Alopecurus pratensis) Meadow grass (Poa pratensis) Meadow grass/Kentucky Blue/June grass (Poa pratensis) Redtop (Agrostis stolonifera) Redtop/Bentgrass/Water Bent grass (Agrostis stolonifera/Agrostis lachnanthis) Rye grass (Lolium perenne) Rye-grass (Lolium perenne) Salt grass (Distichlis spicata) Sedge Family (Cyperaceae) Sedges/Nut grass Sweet Vernal grass (Anthoxanthum odoratum) Sweet vernal grass (Anthoxanthum odoratum) Timothy grass (Phleum pratense) Timothy grass (Phleum pratense) Timothy grass (Phleum pratense) Velvet grass (Holcus lanatus) Velvet grass/Yorkshire Fog (Holcus lanatus) Wild Rye Grass (Elymus triticoides) Wild Rye grass (Elymus triticoides) Animal Venom Bee moth (Galleria mellonella) Berlin Beetle (Trogoderma angustum (Solier)) Blood Worm (Chironomus thummi (C Blowfly (Calliphora stygia/Lucilia euprina) Brazilian fire ant (Solenopsis saevissima) Caterpillar-Browntail moth (Euproctis edwardsi) Cochineal (Dactylopius coccus) Cockroach (Blatella germanica) Colorado Potato Beetle Common clothes moth (Tineola bisselliella) Common Wasp (Vespula sp) Douglas fir tussock moth caterpillar (Orgyia pseudotsugata McDonnough) European Hornet (Vespa crabro) Fire Ant (Solenopsis invicta) Giant Asian Hornet (Vespa mandarina) Grain Weevil (Sitophilus granarius) Green Nimitti Fly (Cladotanytarsus lewisi) Honey Bee (Apis mellifera) Horse Bot Fly (Gasterophilus intestinalis) Maggot/Asticot maggots (Calliphora vomitoria) Mediterranean paper wasp (Polistes dominulus) Midge (Chironomus thummi thummi/ Chironomus kiiensis) Mosquito (Aedes communis) Northern fowl mite (Ornithonyssus sylvarium) Paper Wasp (Polistes spp Phospholipase Pigeon feather mite (Diplaegidia columbae/Pterolichus) Tropical fire ant (Solenopsis geminata) Warehouse moth (Ephestia cautella) Wasp (Polistes metricus) Wasp (Polistes annularis) White faced Hornet (Dolichovespula maculata) Worm (Ascaris suum) Yellow Hornet (Dolichovespula arenaria) Legumes Carob (Ceratonia siliqua) Guar, Guar gum (Cyamopsis tetragonolobus) Lentils (Lens esculenta) Pea (Pisum sativum) Peanut (Arachis hypogaea) Red Kidney bean (Phaseolus vulgaris) Soyabean (Glycine max) Tragacanth (Astragalus spp) White bean (Phaseolus vulgaris) Meats and Milk a-lactalbumin Beef (Bos spp b-lactoglobulin Boiled Milk Casein Cheddar cheese Cow's Milk (Bos domesticus) Cow's Milk Cow's milk Whey Elk/Moose meat Goat's milk Mare's milk Mould cheese Mutton (Ovis spp Pork (Sus spp Rabbit (Oryctolagus spp Mites Acarid mite (Thyreophagus entomophagus) Acarus siro (storage mite) Aleuroglyphus ovatus (Storage Mite) Blomia kulagini (Storage mite) Blomia tjibodas Caloglyphus berlesei Ceflacor Chortoglyphus arcuatus Dermatophagoides farinae (HDM) Dermatophagoides microceras (HDM) Dermatophagoides pteronyssinus (HDM)/Pharinae (Dermatophagoides pteronyssinus) Dermatophagoides siboney (HDM) Euroglyphus maynei (HDM) (Euroglyphus maynei) Glycyphagus domesticus (Storage mite) Hemisarcoptes cooremani House Dust Mite-D House dust mite (HDM) Lepidoglyphus destructor (Storage mite) Mites Predatory mites (Phytoseiulus persimilis /Hypoaspis miles) Rabbit fur mite (Listrophorus gibbus) Scaly grain mite/Suidasia sp Storage Mite-Acarus siro (A Storage Mite-Glycophagus domesticus (Glycophagus) Storage Mite-Lepidoglyphus destructor Storage Mite-Tyrophagus putrescens Molds Alternaria attemata (tenuis) (Altemaria altemata (tenuis)) Altemaria alternat (tenuis) (Altemaria altemata (tenuis)) Altemaria altemata/tenuis (Altemaria altemata (A Aspergillus candidus Aspergillus fumigatus Aspergillus niger Aureobasidium pullulans Botrytis cinera Candida albicans (yeast) Cephalosporium acremonium Cladosporium conidia Cladosporium herbarum Coffee leaf rust (Hemileia vastatrix) Curvularea lunata Epiccocum purpurascens Epicoccum purpurascens/nigrum Fusarium moniliforme (Mold) Helminthosporium halodes Micropolyspora faeni (Saccharopolyspora rectivirgula) Mucor racemosus Mushroom (Oyster) (Pleurotus ostreatus) Penicillium notatum Phoma betae Pityrosporum obiculare Pityrosporum ovale/orbiculare Rhizopus nigricans Silver moss/Reindeer moss/Reindeer lichen (Cladonia stellaris) Spirulina (Arthrospira platensis) Stachybotrys atra Stemphylium botryosum Thermoactinomyces vulgaris Trichoderma viride Trichophyton rubrum Ustilago nuda/tritici/maydis Nuts, Seeds and Beans Acorn nut Alfalfa/Luceme/Medick Almond (Prunus dulcis) Almond (Prunus amygdalus) Almond (Amygdalus communis) Besan/Garbanzo bean Black bean (Phaseolus vulgaris) Black turtle bean Black-eyed bean/Black-eye bean (Vigna sinensis) Brazil Nut (Bertholletia excelsa) Broad bean/Vicia fava bean Field bean (Vicia faba) Butter bean (Phaseolus lunatus) Cashew nut (Anacardium occidentale Castor Bean (Ricinus communis) Chestnut (Castanea sativa) Chickpea (Cicer arietinus) Coconut (Cocos nucifera) Cowpea/Black-eyed peas/Vigna bean (Vigna senensis) Fennel seed (Foeniculum vulgare) Haricot Bean Hazel nut (Corylus avellana) Hazelnut (Corylus avellana) Hazelnut/Filbert/Barcelona Nut/Cob Nut (Corylus avellana) Lentils (Lens culinaris/esculenta) Lima bean (Phaseolus limensis) Linseed/Flaxseed (Linum usitatissimum) Macadamia nut (Macadamia integrifolia/ Macadamia tetraphylla) Mung bean (Vigna radiata) Nangai nut (Canarium indicum) Peanut (Arachis hypogaea) Pecan nut (Carya illinoensis) Pecan Nut/Hickory Nut/Sweet Pignut (Carya illinoensis) Pine Nut/Pinon Nut/Pignoles/Pignola (Pinus edulis) Pinto bean (Phaseolus vulgaris) Pistachio nut (Pistachio vera) Poppy seed (Papaver somniferum) Pumpkin seed (Cucurbita pepo) Pumpkin seed (Cucurbita pepo) Red Kidney bean (Phaseolus vulgaris) Sesame/Sesame seed (Sesamum indicum) Soybean/Soya Bean (Glycine max) Sugar bean Sugar Beet seed (Beta vulgaris) Sunflower seed (Helianthus annuus) Walnut (Juglans spp Walnut (Juglans regia/nigra) Walnut-processed Occupational Amylase Castor bean Chloramine-T/Chloramin T Ethylene Oxide Ethylene oxide Formaldehyde/Paraformaldehyde Green Coffee bean Isocyanate HDI Isocyanate MDI Isocyanate TDI<BR> Ispaghula/Psillium/Psyllium (Plantago psyllium) Isphagula Latex/Brazilian rubber tree (Hevea braziliensis) Lysozyme Phthalic anhydride Silk (Bombyx mori) Silk waste Silk waste Trimellitic anhydride f TMA Parasites Anisakis Anisakis/Cod Worm (Pseudoterranova) Ascaris Ascaris lumbricoides/Common Roundworm (Ascaris lumbricoides) Bilharzia/Schistosoma (Schistosomiasis/ Bilharziasis) Echinococcus/Echinococcosis Entamoeba histolytica Shellfish Blue mussel (Mytilus edulis) Crab (Cancer pagurus) Fish-Mixed Hyssop Lobster (Homarus gammarus) Octopus (Octopus vulgaris) Oyster (Ostrea edulis) Pacific Squid (Todarodes pacificus) Shrimp (Natantia) Shrimp (Pandalus borealis) Silverfish (Ctenolepisma longicaudata/ Lepisma saccharina) Snail (Helix aspersa) Spiny Lobster (Langouste) (Palinurus spp Squid (Loligo spp Spices Allspice (Pimenta dioica (syn Allspice/Clove pepper/Jamaica pepper (Pimenta dioica/officinalis) Angelica/Angelic acid (Angelica archangelica) Anise (Pimpinella anisum) Anise/Aniseed (Pimpinella anisum) Basil (Ocimum basilicum) Basil/Sweet Basil (Ocimum basilicum) Bay Leaf (Laurus nobilis) Bay leaf (Laurus nobilis) Bergamot/Bergamot Orange or Red/ Oswego tea Black Pepper Black Pepper/White Pepper (Piper nigrum) Cacao-processed/Cocoa-processed Capsanthin/Paprika extract Caraway (Carum carvi) Caraway (Carum carvi) Cardamom/Cardemon (Elettaria cardamomum) Cardamon (Elettaria cardamomum) Celery seed Chili peppers (Capsicum frutescens) Chilli Pepper/Chili pepper/Capsicum (Capsicum genus) Chives (Allium schoenoprasum) Cinnamon (Cinnamomum zeylanicum) Clove (Syzygium aromaticum) Comfrey (Symphytum officinale) Coriander/Cilantro/Italian Parsley (Coriandrum sativum) Cumin/Cummin/Cumin oil (Cuminum cyminum) Curry (Santa Maria) Curry leaf (Murraya koenigii) Curry powder/Santa Maria Dill (Anethum graveolens) Fennel/Florence Fennel (Foeniculum vulgare) Fenugreek (Trigonella foenum-graecum) Fenugreek/Greek Hay/Greek Fennel (Trigonella foenum-graecum) Feverfew (Chrysanthemum parthenium) Foxtail Millet (Setaria italic) Galangal root/Chinese ginger/East indian root Garlic extract Ginger (Zingiber officinale) Ginger spice/Ginger (fresh) (Zingiber officinale) Green Pepper (unripe seed) Japanese Millet (Echinochloa crus-galli) Lavender (Lavandula officinalis) Lovage (Levisticum officinale) Mace (Myristica fragrans) Marjoram (Origanum majorana) Mustard (Sinapis alba) Nutmeg (Myristica fragrans) Nutmeg/Nutmeg oil (Myristica fragrans) Oregano (Origanum vulgare) Oriental mustard/BrajI (Brassica juncea) Parsley (Petroselinum crispum) Parsley Pennyroyal oil/Squaw mint/Hedeoma Peppermint (Mentha x piperita) Poppy Seed (Papaver somniferum) Rosemary (Rosmarinus officinalis) Rue (Ruta graveolens/Ruta montana L Saffron (Crocus sativus) Sage (Salvia officinalis) Spearmint/Garden mint/Green mint (Mentha x spicata) Star anise/Anis (Illicium verum) Tansy (Tanacetum vulgare) Tarragon (Artemisia dracunculus) Tarragon/Esdragol (Artemisia dracunculus) Thyme (Thymus vulgaris) Turmeric/Tumeric (Curcuma onga) Vanilla (Vanilla planifolia) Yarrow/Milfoil (Achillea millefolium) Tree pollen Acacia (Acacia longifolia) Acacia tree/Wattle/Port JacksonAloe Vera American beech (Fagus grandifolia) American chestnut tree (Castanea dentata) American Elm (Ulmus americana) Apple tree (pollen) (Malus sylvestris) Aroeira/Litre (Lithraea caustica) Aroeira/Pao bugre (Lithraea brasiliensis) Australian pine tree/Casuarina (Pinus nigra /Casuarina equisetifolia) Bayberry Bark/Myrica Oil Beech Family (Fagaceae) Beechwood/Creosote Bigonia Family (Bigononiaceae) Birch Family (Betualaceae) Black Ash (Fraxinus nigra) Black Walnut Blackwood tree (Acacia melanoxylon/ Dalbergia melanoxylon) Bottlebrush tree (Callistemonand melaleuca) Box elder (Acer negundo) Cabreuva tree (Myrocarpus fastigiatus) Camphor tree oil l Camphor oil/Japanese white oil Canary Island Date Palm tree (Phoenix canariensis) Carob/Locust Bean Gum/St Johns Bread (Ceratonia siliqua/Aka algarroba) Cashew Family (Anacardiaceae) Cashew nut tree (Anacardium occidentale) Cassia bark/Chinese cinnamon (Cinnamomum cassia) Cedar tree/Incense cedar (Libocedrus decurrens) Central American walnut (Juglans olanchana) Chestnut tree Chinese chestnut tree (Castanea mollissima) Cigar Tree (B Coconut (A Common silver birch (Betula verrucosa) Common Silver Birch tree (Betula verrucosa) Cork Cottonwood (Populus deltoides) Cottonwoods, Poplars, and Aspens (Populus) Date Palm tree (Phoenix dactylifera) Douglas Fir tree (Pseudotsuga taxifolia) Eastern red cedar (Juniperus virginiana) Eastern white cedar (Thuja occidentalis) Elm Family (Ulmaceae) Eucalyptus European Chestnut tree (Castanea sativa) Ficus Flat tree/False Banana tree (Platanus occidentalis) Frangipani/Nosegay (Frangipani (Plumeria rubra) ) Grey alder (Alnus incana) Grey Alder tree (Alnus incana/Alnus glutinosa) Guayule (Parthenium argentatum) Gum-tree/Eucalyptus/Cajeput t Hackberry Hazel (Corylus avellana) Hinoki tree/Finuchi tree Holly Family-Aquifoliaceae (Ilex opaca) Honey Locust tree/Mesquite tree (Prosopsis juliflora) Imbuia tree/Embuia tree/ Brazilian-Walnut tree (Phoebe Porosa) Iroko tree/West African teak (Milicia excelsa) Italian cypress (Cupressus sempervirens) Italian Funeral Cypress tree (Cupressus sempervirens) Jacaranda (Jacaranda mimosifolia) Japanese cedar (Cryptomeria japonica) Japanese Cedar tree/Sugi tree (Cryptomeria japonica) Japanese chestnut (Castanea crenata) Juniper berry/Juniper oil (Juniperus communis) Linden tree (Tilia cordata) Lindens (Tiliaceae) London plane (Platanus acerifolia) <BR> <BR> Loquat/Japanese medlar<BR> (Eriobotrya j aponica) Mango tree (Mangifera indica) Maple Family (Acer) Maple tree (Aceraceae) Maritime pine/Cluster pine (Pinus pinaster) <BR> <BR> Melaleuca (Melaleuca leucadendron) Melaleuca tea tree (Melaleuca altemifolia) Mesquite (Prosopis juliflora) Milo wood (Thespesia populnea) Mistletoe (Viscum album) Molle (Lithraea molleoides) Mountain Cedar tree/Mountain Juniper tree (Juniperus sabinoides) Mountain juniper (Juniperus sabinoides) Mulberry (Morus alba) Mulberry Family (Moraceae) Mulberry tree (Morus Alba) Oak (Quercus alba) Obache tree Ohbayasyabushi Alder tree (Alnus sieboldiana Matsuma) Oleander/Oleander tea (Nerium oleander) Olive Family (Oleaceae) Palm Family (Palmae) Paper Mulberry Paperbark Tea Tree (Melaleuca quinquenervia) Peach tree Pecan (Carya pecan) Pecan tree/Hickory tree (Carya pecan/ Carya illinoinensis) Pepper tree (Schinus molle) Pine tree/Norwegian Pine tree (Pinus radiata) Poplar tree/Cottonwood tree/ Matchwood (Populus deltoides/Alba) Populus (Cottonwoods, Poplars, and Aspens) Prickly Juniper tree (Juniperus oxycedrus) Privet tree (Ligustrum vulgare) Prosopis tree Putranjiva tree/Indian amulet tree (Putranjiva roxburghii) Quaking Aspen tree l Western Aspen tree (Populus tremuloides) Queen Palm (Arecastrum romanzoffianum) Red Alder Red Cedar Red Maple Red or River Birch Rosewood Scotch Pine Shellbark Hickory (J Sicilian sumac tree (Rhus coriaria L) Silky Oak (Grevillea robusta) Silver Maple (A Saccharinum) Spruce tree (Picea excels) Sugar date palm (Phoenix sylvestris) Sugar Maple (A Saccharinum) Tibouchina tree/Princess-Flower/Glory Bush (Tibouchina) Virginia live oak tree (Quercus virginiana) Walnut (Juglans califomica) Walnut Family (Juglandaceae) Walnut tree (Juglans califomica) Weeping fig (Ficus benjamina) White Alder White Ash (Fraxinus americana) White Ash (Fraxinus excelsior) White Ash tree (Fraxinus americana/ Fraxinus excelsior) White Birch White cypress pine (Callitris glaucophylla) White Elm tree (Ulmus americana) White Mulberry M White Mulberry White Oak tree (Quercus alba) White pine (Pinus strobus) Willow (Salix caprea) Willow Family (Salicaceae) Yellowood tree (Podocarpus latifolius) Zelkova tree (Zelkova carpinifolia I Zelkova serrata) Vegetables, salads, berries and some fish Abalone/Perloemoen (Haliotis midae) Asparagus Aubergine (Eggplant) Avocado (Persea americana) Bamboo Shoot (Phyllostachys pubescens) Barnacle (Crustacea) Blue Vetch (Mollusc) (Lathyrus sativus) Broccoli Brown shrimp (Crustacea) (Penaeus aztecus) Brussel Sprouts Cabbage Carrot Cauliflower Celery Celery (Apium graveolens) Crab (Crustacea) (Cancer pagurus) Crayfish/Crawfish (Crustacea) Cucumber Fennel, fresh (Foeniculum vulgare) <BR> <BR> Fish-Anchovis/Ansjovis<BR> (Engraulis capensis) Fish-Bass Fish-Bonito/Skipjack (Sarda sarda) Fish-Chub Mackerel (Scombridae japonicus) Fish-Cod (Gadus morhua) Fish-Eel (Anguilla anguilla) Fish-Hake (Merluccius merluccius) Fish-Halibut (Hippoglossus hippoglossus) Fish-Herring (Clupea harengus) Fish-Jack Mackerel/Shad/Scad (Trachurus japonicus) Fish-Mackerel (Scomber scombrus) Fish-Megrim/Whiff/White sole (Lepidorhombus whiffiagonis) Fish-Pilchard (Sardina pitchardus) Fish-Plaice (Pleuronectes platessa) Fish-Salmon (Salmo salar) Fish-Sardine (Sardinops melanosticta) Fish-Snapper Fish-Snoek Fish-Sole (Solea solea) Fish-Swordfish (Xiphias gladius) Fish-Trout (Oncorhynchus mykiss/ Salmo gairdneri) Fish-Tuna (Thunnus albacares/ thynnus) Fish-Western Australian salmon (Arripis truttaceus) Fish-Yellowtail (Seriola lalandii) Garlic (Allium sativum) Gum Arabic (Acacia spp Lettuce Lobster (Crustacea) (Homarus gammarus) Malt Onion Potato Pumpkin Scallop (Mollusc) (Pecten grandis) Scampi (Nephrops norvegicus) Shrimp (Crustacea) (Pandalus borealis) Snails/Escargots (Helix aspersa) Spinach Spiny Lobster/Langouste (Crustacea) (Panulirus vulgaris) Squid (Mollusc) Sweet Potato Tomato Weed pollen Allscale American Beech American Elm American Sycamore Annual Mercury/Annual Dog's Mercury (Mercurialis annua) Aster Family (Asteraceae) Bishop's weed (Ammi majus) Black Oak Burweed marshelder Careless Weed Chrysanthemum spp Cockelbur Cocklebur (Xanthium commune) Cocklebur (Xanthium commune) Cocklebur (weed) (Xanthium commune) Common pigweed (Amaranthus retroflexus) Common ragweed (Ambrosia elatior) Common Wormwood/Absinthe (Artemisia absinthium) Dandelion (Taraxacum vulgare) Diplotaxis erucoides English plantain (Plantago lanceolata) English Plantain (Plantago lanceolata) False ragweed (Franseria acanthicarpa) Firebush (Kochia scoparia) Gas plant/Burning bush (Dictamnus albus) Giant ragweed (Ambrosia trifida) Goatweed Golden Rod/Goldenrod (weed) (Solidago virgaurea) Goosefood/Lamb's Quarter (Chenopodium album) Goosefoot Family (Chenopodiaceae) Hemp (Cannabaceae) Hop Japanese Pollen/Japanese Hop (Humulus japonicus/Humulus scandens) Horse nettle/Bull nettle/Radical weed (Solanum carolinense) Lambs Quarters (Chenopodium) <BR> <BR> Leatherleaf fem/Leather fern/Bakers fern (Rumohra adiantiformis) Mala Mujer (Cnidoscolus angustidens) Mandrake (Mandragora officinarum Mandragora autumnalis) Marguerite (Chrysanthemum leucanthemum) Mugwort (Artemisia vulgaris) Mustard Family (Brassicaceae) Nettle/Stinging Nettle (Urtica dioica) Orchard Grass Poison hemlock (Conium maculatum) Poison Ivy (Toxicodendron radicans) Rabbit Bush Ragweed-False (Franseria acanthicarpa) Ragweed-Giant (Ambrosia trifida) Ragweed-Short/Ragweed-Common Ragweed-Western (Ambrosia psilostachya) Ramat/Garden Mum/ Rocket (Eruca sativa) Rough Marsh Elder (weed)/Annual Marshelder (Iva ciliata) Rough marshelder (Iva ciliata) Russian thistle (Salsola kali (pestifer) Sagebrush Sagebrush/Sage/Wormwood (Artemisia) Saltwort/Russian Thistle (Salsola kali (pestifer)) Scale (Atriplex lentiformis) Scale/Saltbush/Lenscale (Atriplex lentiformis) Shasta daisy (Chrysanthemum maximum) Sheep sorrel (Rumex acetosella) Spiny sowthistle weed (Sonchus oleraceus) Sunflower Thorn apple/Jimson weed/Jamestown weed (Datura stramonium) Wall pellitory (Parietariajudaica) Wall Rocket (Diplotaxis erucoides) Western ragweed (Ambrosia psilostachya) White snakeroot (Eupatorium rugosum) Wormwood (Artemisia absinthium) Yellow Dock U. S. Patents, U. S. patent publications, and other publications mentioned above are hereby incorporated herein by reference in their entirety including incorporated material.

Obviously, many modifications and variations of the present invention are possible in light of the above teachings. It is therefore to be understood that, within the scope of the appended claims, the invention may be practiced otherwise than as specifically described. In particular, the inventors anticipate that antigens chosen from one family of materials will be protective against allergies to other classes of antigens, and these cross protection materials will be found in the course of ordinary experimentation as known to one in the art.