Title:
METHOD AND APPARATUS FOR SIMULTANEOUSLY MANUFACTURING ULTRA PURE BETULIN AND HIGHLY PURE BETULINIC ACID FROM BIRCH BARK
Document Type and Number:
WIPO Patent Application WO/2011/074766
Kind Code:
A2
Abstract:
The present invention relates to a method and apparatus for simultaneously manufacturing ultra pure betulin and highly pure betulinic acid from birch bark, which employ a technique of: using a polar organic solvent to obtain a crude extract containing a betulin content of 70 to 83% and a betulinic acid content of 4 to 8% from the outer bark and inner bark of birch trees that grow naturally in northern hemisphere regions at a northern latitude of 34° or greater, such as in South Korea, China, North America, and Europe; and using a single or mixed polar solvent to obtain a crystallized highly pure betulin with a purity of 95% or greater, wherein ultra pure betulin with a purity of 99.5% or greater and highly pure betulinic acid with a purity of 95% or greater can be simultaneously produced from the crystallized product.
Inventors:
CHUE KUCK-TACK (KR)
PARK JONG-KEE (KR)
KIM TAE-HWAN (KR)
YI CHANG-KEUN (KR)
PARK JONG-KEE (KR)
KIM TAE-HWAN (KR)
YI CHANG-KEUN (KR)
Application Number:
PCT/KR2010/006329
Publication Date:
June 23, 2011
Filing Date:
September 16, 2010
Export Citation:
Assignee:
KOREA ENERGY RESEARCH INST (KR)
CHUE KUCK-TACK (KR)
PARK JONG-KEE (KR)
KIM TAE-HWAN (KR)
YI CHANG-KEUN (KR)
CHUE KUCK-TACK (KR)
PARK JONG-KEE (KR)
KIM TAE-HWAN (KR)
YI CHANG-KEUN (KR)
International Classes:
A61K36/185; B01D9/00; B01D11/00
Foreign References:
US6280778B1 | 2001-08-28 | |||
US6392070B1 | 2002-05-21 | |||
US6634575B2 | 2003-10-21 | |||
US6815553B2 | 2004-11-09 | |||
US7246184B2 | 2007-07-17 | |||
KR20030067545A | 2003-08-14 | |||
KR100827072B1 | 2008-05-02 | |||
KR100770940B1 | 2007-10-26 |
Other References:
See references of EP 2514430A4
Attorney, Agent or Firm:
CHANG, Soon-Boo et al. (KR)
장순부 (KR)
장순부 (KR)
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