Title:
METHOD AND ASSAY FOR DIAGNOSING RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS IN A SUBJECT
Document Type and Number:
WIPO Patent Application WO/2016/166357
Kind Code:
A3
Abstract:
A method for identifying an individual with active crescentic glomerulonephritis (CGN), the method comprising the step of assaying a biological sample obtained from the individual for the presence of an elevated level of sCD163 when compared to levels in a reference sample, wherein an elevated level of sCD163 when compared to levels in a reference sample correlates with the individual having active CGN.
Inventors:
LITTLE MARK (IE)
Application Number:
PCT/EP2016/058471
Publication Date:
January 12, 2017
Filing Date:
April 16, 2016
Export Citation:
Assignee:
THE PROVOST FELLOWS FOUND SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIV T (IE)
International Classes:
G01N33/68
Other References:
TSUBOI NAOTAKE ET AL: "Association of Glomerular Macrophage Phenotypes and Urine Soluble CD163 with Disease Activity in Human Lupus Nephritis", ARTHRITIS & RHEUMATOLOGY (HOBOKEN), JOHN WILEY & SONS, INC, US, vol. 66, no. Suppl.10, 1 October 2014 (2014-10-01), pages S727, XP009191726, ISSN: 2326-5191
O'REILLY VINCENT P ET AL: "Urinary Soluble CD163 in Active Renal Vasculitis", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, LIPPINCOTT WILLIAMS & WILKINS, US, vol. 27, no. 9, 1 September 2016 (2016-09-01), pages 2906 - 2916, XP009191718, ISSN: 1533-3450, DOI: 10.1681/ASN.2015050511
LONGXIANG SU ET AL: "Diagnostic value of urine sCD163 levels for sepsis and relevant acute kidney injury: a prospective study", BMC NEPHROLOGY, BIOMED CENTRAL, LONDON, GB, vol. 13, no. 1, 26 September 2012 (2012-09-26), pages 123, XP021120340, ISSN: 1471-2369, DOI: 10.1186/1471-2369-13-123
IKEZUMI YOHEI ET AL: "Alternatively activated macrophages in the pathogenesis of chronic kidney allograft injury", PEDIATRIC NEPHROLOGY, SPRINGER VERLAG, BERLIN, DE, vol. 30, no. 6, 9 December 2014 (2014-12-09), pages 1007 - 1017, XP035490414, ISSN: 0931-041X, [retrieved on 20141209], DOI: 10.1007/S00467-014-3023-0
O'REILLY VINCENT P ET AL: "Urinary Soluble CD163 in Active Renal Vasculitis", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, LIPPINCOTT WILLIAMS & WILKINS, US, vol. 27, no. 9, 1 September 2016 (2016-09-01), pages 2906 - 2916, XP009191718, ISSN: 1533-3450, DOI: 10.1681/ASN.2015050511
LONGXIANG SU ET AL: "Diagnostic value of urine sCD163 levels for sepsis and relevant acute kidney injury: a prospective study", BMC NEPHROLOGY, BIOMED CENTRAL, LONDON, GB, vol. 13, no. 1, 26 September 2012 (2012-09-26), pages 123, XP021120340, ISSN: 1471-2369, DOI: 10.1186/1471-2369-13-123
IKEZUMI YOHEI ET AL: "Alternatively activated macrophages in the pathogenesis of chronic kidney allograft injury", PEDIATRIC NEPHROLOGY, SPRINGER VERLAG, BERLIN, DE, vol. 30, no. 6, 9 December 2014 (2014-12-09), pages 1007 - 1017, XP035490414, ISSN: 0931-041X, [retrieved on 20141209], DOI: 10.1007/S00467-014-3023-0
Attorney, Agent or Firm:
CARMODY, Mark (IE)
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