Title:
METHOD FOR ASSAYING CHONDROCALCINE
Document Type and Number:
WIPO Patent Application WO/1989/011097
Kind Code:
A1
Abstract:
A method for assaying chondrocalcine by immunological technique using enzyme-labeled chondrocalcine or anti-chondrocalcine antibody of a mammal, which comprises using the body fluid of a mammal as a specimen and assaying chondrocalcine of the mammal utilizing immuno-reaction in a solution, is disclosed. Assaying reagents and kits for the method are also disclosed. The method, reagents and kits can be utilized for, e.g., diagnosis of cartilaginous diseases of mammals.
Inventors:
MATSUZAWA KIMIHIKO (JP)
ITOU KAZUHIKO (JP)
HONDA HITOMI (JP)
HASEGAWA RYOICHI (JP)
OKAMOTO NAOMI (JP)
HOSODA KENJI (JP)
SHINMEI MASAYUKI (JP)
MATSUYAMA SHIGEO (JP)
ITOU KAZUHIKO (JP)
HONDA HITOMI (JP)
HASEGAWA RYOICHI (JP)
OKAMOTO NAOMI (JP)
HOSODA KENJI (JP)
SHINMEI MASAYUKI (JP)
MATSUYAMA SHIGEO (JP)
Application Number:
PCT/JP1989/000138
Publication Date:
November 16, 1989
Filing Date:
February 10, 1989
Export Citation:
Assignee:
TEIJIN LTD (JP)
International Classes:
C07K16/18; G01N33/68; (IPC1-7): G01N33/53; G01N33/543; G01N33/577
Foreign References:
| JPS62116262A | 1987-05-27 | |||
| JPH06224149A | 1994-08-12 | |||
| JPS60130825A | 1985-07-12 |
Other References:
The Journal of Cell Biology, Vol. 98, No. 1, (1984), A.R. POOLE et al. (Association of an Extracellular Protein (Chondrocalcin) with the Calufication of Cartilage in Endochondral Bone Fromation) p. 54-65
The Journal of Cell Biology, Vol. 104, No. 5, (1987), ALEKSANDER HINEK et al. (The Calcification of Cartilage Martrix Chondrocyte Culture : Studies of the C-Propeptide of Type II Collagen (Chondrocalcin) p. 1435-1441
J. Anat., Vol. 150, (1987), E. LIUNE et al. (Age-Related Changes in the Role of Matrix Vesicles in the Mandibular Condylar Cartilage) p. 61-74
The Journal of Cell Biology, Vol. 104, No. 5, (1987), ALEKSANDER HINEK et al. (The Calcification of Cartilage Martrix Chondrocyte Culture : Studies of the C-Propeptide of Type II Collagen (Chondrocalcin) p. 1435-1441
J. Anat., Vol. 150, (1987), E. LIUNE et al. (Age-Related Changes in the Role of Matrix Vesicles in the Mandibular Condylar Cartilage) p. 61-74
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