METHOD FOR ASSESSING CANCER RISK

WIPO Patent Application WO/2019/208738

A1

This novel method assesses whether a subject belongs to a cancer risk group by analyzing oral-cavity bacterial flora derived from the subject, the method including: a step in which a Mahalanobis distance (Dp) of a bacterial flora ratio Pt from a data group obtained by adding data for the bacterial flora ratio Pt derived from the subject to a data group (Pp data group) of a bacterial flora ratio Pp derived from a plurality of cancer patients is calculated; a step in which a Mahalanobis distance (Dn) of the bacterial flora ratio Pt from a data group obtained by adding data for the bacterial flora ratio Pt derived from the subject to a data group (Pn data group) of a bacterial flora ratio Pn derived from a plurality of healthy individuals is calculated; and a step in which, if Dp is less than Dn, the bacterial flora structure of the oral-cavity bacterial flora derived from the subject is assessed to belong to a cancer risk group.

OKAMOTO TETSUJI (JP)
TANI RYOUJI (JP)
MATSUI KENSAKU (JP)
TOKUMARU KOICHIRO (JP)
OHTOMO TAKESHI (JP)

PCT/JP2019/017806

October 31, 2019

April 25, 2019

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UNIV HIROSHIMA (JP)
NIHON KEFIR CO LTD (JP)

C12Q1/04; C12N15/09; C12Q1/683

JP2015520176A

2015-07-16

ZHAO, H. ET AL.: "Variations in oral microbiota associated with oral cancer", SCI. REP., vol. 7, no. 11773, 2017, pages 1 - 10

AXIS PATENT INTERNATIONAL et al. (JP)

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