METHOD FOR ASSESSING CELL STATE AND DEVICE FOR ASSESSING CELL STATE

WIPO Patent Application WO/2019/175959

A1

A microscope observation unit (1) acquires hologram data pertaining to a culture plate (12) that includes a colony (13), and a phase information calculation unit (22) and a moving image creation unit (23) perform prescribed processing on the data to thereby create a phase image. A texture feature value computation unit (241) and a texture feature image creation unit (242) perform statistical texture analysis on each small region of the phase image and create multiple types of texture feature images. A cell region extraction unit (243) extracts a colony region from a texture feature image, and an index value calculation unit (244) computes index values such as the mean or standard deviation from the feature values included in the colony region on the texture feature image. A state assessment processing unit (245) assesses whether there are undifferentiated aberrant cells in the colony by machine learning in which multiple types of index values are used. This makes it possible to accurately and non-invasively assess whether cells, or cells in a colony, are in an undifferentiated aberrant state.

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WO/2016/187996	CIRCULAR FLOW TYPE PHOTOBIOREACTOR SYSTEM

AKAZAWA AYAKO (JP)

PCT/JP2018/009698

September 19, 2019

March 13, 2018

Click for automatic bibliography generation  

SHIMADZU CORP (JP)

C12M1/34

WO2017126615A1	2017-07-27
WO2013138513A1	2013-09-19
WO2015025506A1	2015-02-26

CHALUT, K. J. ET AL.: "Quantifying cellular differentiation by physical phenotype using digital holographic microscopy", INTEGR. BIOL., vol. 4, no. 3, 2012, pages 280 - 284, ISSN: 1757-9708

KYOTO INTERNATIONAL PATENT LAW OFFICE (JP)

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