METHOD FOR ASSESSING IMMUNITY AND PROVIDING INFORMATION ON WHETHER OR NOT THE ONSET OF CANCER HAS BEGUN BY UTILIZING DIFFERENCE IN IMMUNE CELL DISTRIBUTION BETWEEN PERIPHERAL BLOOD OF COLORECTAL CANCER PATIENT AND NORMAL PERSON, AND DIAGNOSTIC KIT USING SAME

Title:

Document Type and Number:

WIPO Patent Application WO/2018/221820

Kind Code:

A1

Abstract:

Provided according to the present invention is a method for assessing immunity of peripheral blood and providing information on whether or not the onset of colorectal cancer has begun by utilizing a difference in immune cell distribution between peripheral blood of colorectal cancer patients and normal persons, the method comprising the steps of: (A) analyzing peripheral blood immune cells for cell size and wrinkle degree to classify the cells into lymphocytes, monocytes, and granulocytes; (B) staining a labeling marker of the three kinds of immune cells with at least one antibody combination to analyze the distribution of immune cells in peripheral bloods of cancer patients and normal persons; (C) discriminating sets in which meaningful result values of the labeling marker are different between the two groups, cancer patients and normal persons, with statistical significance, so as to discriminate whether or not the onset of cancer has begun among cancer patients and normal persons; and (D) measuring immunity per unit of blood by means of the labeling marker to diagnose whether or not the onset of colorectal cancer has begun, without counting natural killer cells with a flow cytometer or a cell counter.

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Inventors:

LEE JONG KYUN (KR)
CHOI JOUNG BUM (KR)

Application Number:

PCT/KR2018/000505

Publication Date:

December 06, 2018

Filing Date:

January 11, 2018

Export Citation:

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Assignee:

LEE JONG KYUN (KR)

International Classes:

G01N33/574; G01N15/14; G01N33/569; G01N33/58

Foreign References:

KR101483883B1	2015-01-19
KR20120077568A	2012-07-10
JP4608704B2	2011-01-12
JP2010145205A	2010-07-01

Other References:

MASUYAMA, J.I. ET AL: "Ex vivo expansion of natural killer cells from human peripheral blood mononuclear cells-co-stimulated with anti-CD-3 and anti-CD52 monoclonal antibodies", CYTOTHERAPY, vol. 18, no. 1, 6 November 2015 (2015-11-06), pages 80 - 90, XP055637886, ISSN: 1465-3249, DOI: 10.1016/j.jcyt.2015.09.011

Attorney, Agent or Firm:

KIM, Joon Ha (KR)

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