Title:
METHOD FOR ASSISTING DETECTION OF PANCREATIC CANCER
Document Type and Number:
WIPO Patent Application WO/2015/133477
Kind Code:
A1
Abstract:
Disclosed is the provision of a method for assisting the detection of pancreatic cancer, whereby it becomes possible to assist the highly accurate detection of pancreatic cancer. In the method for assisting the detection of pancreatic cancer, the amount of (1) miR-122-5p and the amount of (2) at least one type of miRNA selected from the group consisting of miR-16-5p, miR-19b-3p and miR-25-3p in a test sample separated from a living body are employed as measures. When the amount of miR-122-5p is larger than that in a normal person and the amount of the at least one type of miRNA selected from the group consisting of miR-16-5p, miR-19b-3p and miR-25-3p is smaller than that in a normal person, it is indicated that there is a high probability of developing pancreatic cancer.
Inventors:
TAHARA HIDETOSHI (JP)
IKEDA KOZUE (JP)
IKEDA KOZUE (JP)
Application Number:
PCT/JP2015/056219
Publication Date:
September 11, 2015
Filing Date:
March 03, 2015
Export Citation:
Assignee:
UNIV HIROSHIMA (JP)
International Classes:
C12N15/09; C12Q1/68
Other References:
GANEPOLA GANEPOLA AP ET AL.: "Novel blood-based microRNA biomarker panel for early diagnosis of pancreatic cancer", WORLD J GASTROINTEST ONCOL, vol. 6, no. 1, January 2014 (2014-01-01), pages 22 - 33, XP055222920, ISSN: 1948-5204
PAN FENG ET AL.: "Correlation of serum microRNA profiling with pancreatic cancer risk", ACTA UNIV MED NANJING, vol. 32, no. 11, 2012, pages 1541 - 1544, XP008184567
LIU RUI ET AL.: "Serum MicroRNA Expression Profile as a Biomarker in the Diagnosis and Prognosis of Pancreatic Cancer", CLINICAL CHEMISTRY, vol. 58, no. 3, 2012, pages 610 - 618, XP055222921, ISSN: 0009-9147
KOZUE IKEDA ET AL.: "Kesshochu miRNA o Mochiita Suigan Tokuiteki na Biomarker no Tansaku to Jisedai Sequencer ni yoru Hairetsu Kaiseki no Kanosei", THE 36TH ANNUAL MEETING OF THE MOLECULAR BIOLOGY SOCIETY OF JAPAN YOSHISHU, vol. 3P-E-d, 20 November 2013 (2013-11-20), pages 3P-0881, XP008184694, Retrieved from the Internet [retrieved on 20140325]
JANAKIRAM NAVEENA B. ET AL.: "Abstract 821: miRNA profiling and target identification during normal pancreata transformation to PanINs to pancreatic ductal cancer progression in p48Cre/+-LSL-KrasG12D/+ mice: Implication for human pancreatic cancer chemoprevention and treatment", CANCER RES, vol. 71, no. Suppl.8, 2011
PAN FENG ET AL.: "Correlation of serum microRNA profiling with pancreatic cancer risk", ACTA UNIV MED NANJING, vol. 32, no. 11, 2012, pages 1541 - 1544, XP008184567
LIU RUI ET AL.: "Serum MicroRNA Expression Profile as a Biomarker in the Diagnosis and Prognosis of Pancreatic Cancer", CLINICAL CHEMISTRY, vol. 58, no. 3, 2012, pages 610 - 618, XP055222921, ISSN: 0009-9147
KOZUE IKEDA ET AL.: "Kesshochu miRNA o Mochiita Suigan Tokuiteki na Biomarker no Tansaku to Jisedai Sequencer ni yoru Hairetsu Kaiseki no Kanosei", THE 36TH ANNUAL MEETING OF THE MOLECULAR BIOLOGY SOCIETY OF JAPAN YOSHISHU, vol. 3P-E-d, 20 November 2013 (2013-11-20), pages 3P-0881, XP008184694, Retrieved from the Internet
JANAKIRAM NAVEENA B. ET AL.: "Abstract 821: miRNA profiling and target identification during normal pancreata transformation to PanINs to pancreatic ductal cancer progression in p48Cre/+-LSL-KrasG12D/+ mice: Implication for human pancreatic cancer chemoprevention and treatment", CANCER RES, vol. 71, no. Suppl.8, 2011
Attorney, Agent or Firm:
TANIGAWA AND PARTNERS, PATENT FIRM (JP)
Patent business corporation mountain stream international patent firm (JP)
Patent business corporation mountain stream international patent firm (JP)
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