Title:
METHOD FOR AVOIDING IMMUNE REJECTION USING AGONIST FOR INHIBITORY KIR
Document Type and Number:
WIPO Patent Application WO/2024/090458
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide: a substance which has an activity of binding to an inhibitory KIR to inhibit the cytotoxic activity of an NK cell and is useful for allogeneic technologies associated with organ transplantation and cell therapy; and a method for producing the substance. Provided are: a substance which has an activity of binding to an inhibitory KIR to inhibit the cytotoxic activity of an NK cell; and a cell which has the substance expressed on a cell surface thereof.
Inventors:
UENO SUGURU (JP)
IKEDA KAZUYA (JP)
NAKAYAMA MAKIKO (JP)
HIURA SATOSHI (JP)
YOSHIDA SAYAKA (JP)
NAKAMURA KENSUKE (JP)
KUWASAKI YUTO (JP)
NISHIKAWA YOSUKE (JP)
KIMURA TAKAKO (JP)
IKEDA KAZUYA (JP)
NAKAYAMA MAKIKO (JP)
HIURA SATOSHI (JP)
YOSHIDA SAYAKA (JP)
NAKAMURA KENSUKE (JP)
KUWASAKI YUTO (JP)
NISHIKAWA YOSUKE (JP)
KIMURA TAKAKO (JP)
Application Number:
PCT/JP2023/038440
Publication Date:
May 02, 2024
Filing Date:
October 25, 2023
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
International Classes:
C07K16/28; A61K35/17; A61K35/22; A61K35/28; A61K35/30; A61K35/32; A61K35/34; A61K35/39; A61K35/407; A61K35/545; A61K39/395; A61P37/06; C12N5/071; C12N5/0783; C12N5/10; C12N15/13; C12Q1/02
Foreign References:
| US20170334993A1 | 2017-11-23 | |||
| JP2008526221A | 2008-07-24 | |||
| EP3992204A1 | 2022-05-04 | |||
| JP2008506368A | 2008-03-06 | |||
| JP2008500947A | 2008-01-17 |
Other References:
VITALE M, ET AL.: "ISOLATION OF A NOVEL KIR2DL3-SPECIFIC MAB: COMPARATIVE ANALYSIS OF THE SURFACE DISTRIBUTION AND FUNCTION OF KIR2DL2, KIR2DL3 AND KIR2DS2", INTERNATIONAL IMMUNOLOGY, OXFORD UNIVERSITY PRESS, GB, vol. 16, no. 10, 1 October 2004 (2004-10-01), GB , pages 1459 - 1466, XP009040792, ISSN: 0953-8178, DOI: 10.1093/intimm/dxh147
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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